Omega-3 fatty acids supplementation and risk of atrial fibrillation: an updated meta-analysis of randomized controlled trials

Lombardi, Marco; Carbone, Salvatore; Buono, Marco Giuseppe Del; Chiabrando, Juan Guido; Vescovo, G; Camilli, Massimiliano; Montone, Rocco Antonio; Vergallo, Rocco; Abbate, Antonio; Biondi‐Zoccai, Giuseppe; Crea, Filippo

doi:10.1093/ehjcvp/pvab008

Cited by 34 publications

(15 citation statements)

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“…36 A recent metaanalysis of five RCTs showed a 37% increase in atrial fibrillation with O3FA supplementation (IRR 1.37, 95% CI 1.22-1.54) with low heterogeneity. 37 Overall, though the biologic mechanism is unclear, and more data are required, the current evidence suggests that the increase in incident atrial fibrillation with O3FA is a true finding.…”

Section: Sa Fe T Ymentioning

confidence: 89%

Omega‐3 fatty acids for the prevention of atherosclerotic cardiovascular disease

Barry

2021

Pharmacotherapy

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Omega-3 fatty acids (O3FA) are a type of polyunsaturated fatty acids that are essential to maintain normal cellular function. There are three main types of O3FA: alpha-linolenic acid (ALA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). 1 Although ALA is derived from plant sources, DHA and EPA are mostly derived from marine sources, such as fish, krill, and squid. There are many purported health benefits of O3FA including the prevention or treatment of inflammatory conditions, cancer, cognitive impairment, mental health disorders, and atherosclerotic cardiovascular disease (ASCVD). 2 The latter of which largely stems from epidemiological data showing that population groups (e.g., Inuit Peoples) with a high dietary intake in O3FA have a significantly lower risk of ASCVD

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Section: Sa Fe T Ymentioning

confidence: 89%

Omega‐3 fatty acids for the prevention of atherosclerotic cardiovascular disease

Barry

2021

Pharmacotherapy

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“…Other risks associated with statin use, including hemorrhagic stroke in those with previous stroke, are not of clinically important magnitude ( 69 , 70 , 71 ). New-onset or worsening of atrial fibrillation is a concern with omega-3 fatty acids ( 72 , 73 , 74 ), and increased bleeding due to the effects on platelet aggregation should be monitored in the RCT results.…”

Section: Discussionmentioning

confidence: 99%

Investigating Lipid-Modulating Agents for Prevention or Treatment of COVID-19

Talasaz

Sadeghipour

Aghakouchakzadeh

et al. 2021

Journal of the American College of Cardiology

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“…Last, but not least, EPA and DHA have been credited with anti-arrhythmic activities, as shown by in vitro studies [20] and early human trials [20]. However, recent evidence shows the exact opposite, i.e., fish oil administration increased atrial fibrillation in a meta-analysis of secondary prevention RCTs [21]. This effect was stronger in high-risk patients and in those with elevated plasma triglycerides [21].…”

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confidence: 99%