Omega-3 fatty acids promote neuroprotection, decreased apoptosis and reduced glial cell activation in the retina of a mouse model of OPA1-related autosomal dominant optic atrophy

Kalogerou, Maria; Ioannou, Sotiris; Kolovos, Panagiotis; Prokopiou, Ekatherine; Potamiti, Louiza; Kyriacou, Kyriacos; Panagiotidis, Michail; Ioannou, Maria S.; Fella, Eleni; Worth, E. Panayiotou; Georgiou, Tassos

doi:10.1016/j.exer.2021.108901

Cited by 12 publications

(6 citation statements)

References 86 publications

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“…The retinal neuroprotective effects of DHA and EPA in combination with timolol have been reported in studies examining treatment strategies for hereditary glaucoma in murine models [110]. Similar neuroprotective effects via omega-3s have also been observed for murine hereditary optic atrophy and anterior ischemic optic neuropathy, respectively [111,112]. There may also be potential benefits to intraocular pressure (IOP) management in ocular hypertension (OHT) and normal tension glaucoma (NTG) [30].…”

Section: Omega-3mentioning

confidence: 79%

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

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Glaucoma is a chronic optic neuropathy that can lead to irreversible functional and morphological damage if left untreated. The gold standard therapeutic approaches in managing patients with glaucoma and limiting progression include local drops, laser, and/or surgery, which are all geared at reducing intraocular pressure (IOP). Nutrients, antioxidants, vitamins, organic compounds, and micronutrients have been gaining increasing interest in the past decade as integrative IOP-independent strategies to delay or halt glaucomatous retinal ganglion cell degeneration. In our minireview, we examine the various nutrients and compounds proposed in the current literature for the management of ophthalmology diseases, especially for glaucoma. With respect to each substance considered, this minireview reports the molecular and biological characteristics, neuroprotective activities, antioxidant properties, beneficial mechanisms, and clinical studies published in the past decade in the field of general medicine. This study highlights the potential benefits of these substances in glaucoma and other ophthalmologic pathologies. Nutritional supplementation can thus be useful as integrative IOP-independent strategies in the management of glaucoma and in other ophthalmologic pathologies. Large multicenter clinical trials based on functional and morphologic data collected over long follow-up periods in patients with IOP-independent treatments can pave the way for alternative and/or coadjutant therapeutic options in the management of glaucoma and other ocular pathologies.

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Section: Omega-3mentioning

confidence: 79%

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

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“…Considering the mounting evidence highlighting the significance of the ω6 to ω3 PUFA ratio ( 23 , 24 , 25 ), particularly regarding retinal inflammation observed in AdipoR1 −/− mice prior to the onset of photoreceptor degeneration ( 9 ), we calculated the ω6/ω3 ratio in the AdipoR1 −/− and WT samples. Our findings revealed a substantial elevation in the ω6/ω3 ratio, which was 10.5-fold higher in the retina ( p < 0.0001; Fig.…”

Section: Resultsmentioning

confidence: 99%

“…While both PUFA types ω6 and ω3 are important for retina development ( 25 ), the excess of ω6 PUFAs compared to ω3, observed in pathological conditions such as AdipoR1 ablation, could contribute to chronic inflammation in the retina and other tissues. Hence, the elevation of the ω6/ω3 ratio may be a risk factor in retinal diseases ( 23 , 24 , 25 , 43 ).…”

Section: Discussionmentioning

confidence: 99%

Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice

Lewandowski,

Gao,

Imanishi

et al. 2024

Journal of Biological Chemistry

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“…Changes in lipid metabolism are related to the NAFLD development process and its progression, affecting organelles such as mitochondria and ER [ 60 ]. Marinho et al [ 24 ] have already shown that a high-fat diet is capable of compromising the mitochondrial ultrastructure and disorganizing the cytoarchitecture.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice

Lontro Alves,

Gomes Pereira,

Torres Ciambarella

et al. 2024

Journal of Obesity

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Obesity is a complex chronic disease characterized by excess body fat (adipose) that is harmful to health and has been a major global health problem. It may be associated with several diseases, such as nonalcoholic fatty liver disease (NAFLD). Polyunsaturated fatty acids (PUFA) are lipid mediators that have anti-inflammatory characteristics and can be found in animals and plants, with capybara oil (CO) being a promising source. So, we intend to evaluate the hepatic pathophysiological alterations in C57Bl/6 mice with NAFLD, caused by obesity, and the possible beneficial effects of OC in the treatment of this disease. Eighteen 3-month-old male C57Bl/6 mice received a control or high-fat diet for 18 weeks. From the 15th to the 18th week, the animals received treatment—through orogastric gavage—with placebo or free capybara oil (5 g/kg). Parameters inherent to body mass, glucose tolerance, evaluation of liver enzymes, percentage of hepatic steatosis, oxidative stress, the process of cell death with the apoptotic biomarkers (Bax, Bcl2, and Cytochrome C), and the ultrastructure of hepatocytes were analyzed. Even though the treatment with CO was not able to disassemble the effects on the physiological parameters, it proved to be beneficial in reversing the morphological and ultrastructural damage present in the hepatocytes. Thus, demonstrating that CO has beneficial effects in reducing steatosis and the apoptotic pathway, it is a promising treatment for NAFLD.

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Omega-3 fatty acids promote neuroprotection, decreased apoptosis and reduced glial cell activation in the retina of a mouse model of OPA1-related autosomal dominant optic atrophy

Cited by 12 publications

References 86 publications

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice

Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice

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