Omega-3 fatty-acids modulate symptoms of depressive disorder, serum levels of omega-3 fatty acids and omega-6/omega-3 ratio in children. A randomized, double-blind and controlled trial

Trebatická, Jana; Hradečná, Zuzana; Surovcová, Anna; Katrenčíková, Barbora; Gushina, Irina; Waczulíková, Iveta; Susienkova, K; Garaiová, Iveta; Šuba, Ján; Ďuračková, Zdeňka

doi:10.1016/j.psychres.2020.112911

Cited by 51 publications

(82 citation statements)

References 54 publications

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“…Significant reductions in CDI scores were observed after 6 and 12 weeks of intervention in the Om3 group compared to the Om6 group. The ratio of omega-6/omega-3 decreased in Om3 but not in Om6 from 24.2/1 to 7.6/1 after 6 weeks; EPA and omega-6/omega-3 ratio, but not DHA, correlated with severity symptoms at the baseline [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

“…The presented results are part of the Depoxin project registered under ID number ISRCTN81655012, in which the primary objective was to monitor the effect of omega-3 FA compared to an omega-6 FA on the severity of depression as assessed by the Children’s Depression Inventory (CDI) score [ 9 ]. The secondary objective was to monitor the effect of omega-3 FA on selected biochemical parameters, among others, on the lipid profile, lipoprotein subfractions, and interactions between them.…”

Section: Methodsmentioning

confidence: 99%

“…If the data was skewed but other criteria were met, a nonparametric Mann–Whitney U test was used. In our previous paper [ 9 ], we have demonstrated that improvement of clinical symptoms of depression occurred after 6 weeks of supplementation with omega-3 fatty acid. Thus, we have selected the time interval of week 6 to investigate the consequences of omega-3 and omega-6 fatty acid supplementation.…”

Section: Methodsmentioning

confidence: 99%

“…The ratio of omega-3 FA to omega-6 FA in the diet has shifted from 1:1 to 1:15–20, and this switch has coincided with a strong rise in the rates of depression in recent decades [ 6 ]. This has led to the hypothesis that omega-3 FA supplementation could represent an approach for treating depression and other mood disorders [ 7 , 8 , 9 ]. This assumption is supported by the knowledge about the biological effects of omega-3 and omega-6 FA (anti-inflammatory and proinflammatory eicosanoids formation, cell membrane fluidity, cell membrane function, and regulation of proinflammatory cytokine gene expression) [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Proinflammatory eicosanoids are formed from arachidonic acid [ 30 ]. The incorrect omega-6/omega-3 ratio is thought to contribute to the pathophysiology of depressive disorder rather than the reduced EPA concentration alone [ 9 ]. The effect of omega-3 FA on depressive symptoms is thought to exert through membrane fluidity modulation, neuronal development, inflammation, and neurotransmission [ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

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Lipid Profile, Lipoprotein Subfractions, and Fluidity of Membranes in Children and Adolescents with Depressive Disorder: Effect of Omega-3 Fatty Acids in a Double-Blind Randomized Controlled Study

et al. 2020

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Depressive disorder (DD) is a psychiatric disorder whose molecular basis is not fully understood. It is assumed that reduced consumption of fish and omega-3 fatty acids (FA) is associated with DD. Other lipids such as total cholesterol (TCH), LDL-, and HDL-cholesterols (LDL-CH, HDL-CH) also play a role in depression. The primary endpoint of the study was the effect of omega-3 FA on the severity of depression in children and adolescents. This study aimed to investigate the secondary endpoint, relationship between depressive disorder symptoms and lipid profile, LDL- and HDL-cholesterol subfractions, Paraoxonase 1 (PON1) activities, and erythrocyte membrane fluidity in 58 depressed children and adolescents (calculated by the statistical program on the effect size), as well as the effect of omega-3 FA on the monitored parameters. Depressive symptoms were assessed by the Children’s Depression Inventory (CDI), lipid profile by standard biochemical procedures, and LDL- and HDL-subfractions by the Lipoprint system. Basic biochemical parameters including lipid profile were compared with levels in 20 healthy children and were in the physiological range. Improvement of symptoms in the group supplemented with a fish oil emulsion rich in omega-3 FA in contrast to omega-6 FA (emulsion of sunflower oil) has been observed. We are the first to report that omega-3 FAs, but not omega-6 FA, increase large HDL subfractions (anti-atherogenic) after 12 weeks of supplementation and decrease small HDL subfractions (proatherogenic) in depressed children. We found a negative correlation between CDI score and HDL-CH and the large HDL subfraction, but not LDL-CH subfractions. CDI score was not associated with erythrocyte membrane fluidity. Our results suggest that HDL-CH and its subfractions, but not LDL-CH may play a role in the pathophysiology of depressive disorder. The study was registered under ISRCTN81655012.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lipid Profile, Lipoprotein Subfractions, and Fluidity of Membranes in Children and Adolescents with Depressive Disorder: Effect of Omega-3 Fatty Acids in a Double-Blind Randomized Controlled Study

et al. 2020

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Reconsidering Meat Intake and Human Health: A Review of Current Research

Xie

Cai

et al. 2022

Molecular Nutrition Food Res

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Meat consumption is gradually increasing and its impact on health has attracted widespread attention, resulting in epidemiological studies proposing a reduction in meat and processed meat intake. This review briefly summarizes recent advances in understanding the effects of meat or processed meat on human health, as well as the underlying mechanisms. Meat consumption varies widely among individuals, populations, and regions, with higher consumption in developed countries than in developing countries. However, increasing meat consumption may not be the main cause of increasing incidence of chronic disease, since the development of chronic disease is a complex physiological process that involves many factors, including excessive total energy intake and changes in food digestion processes, gut microbiota composition, and liver metabolism. In comparison, unhealthy dietary habits and a sedentary lifestyle with decreasing energy expenditure are factors more worthy of reflection. Meat and meat products provide high‐value protein and many key essential micronutrients. In short, as long as excessive intake and overprocessing of meats are avoided, meat remains an indispensable source of nutrition for human health.

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S3-Leitlinie Depressive Störungen im Kindes- und Jugendalter: Wo geht es hin?

Schulte-Körne,

Klingele,

Zsigo

et al. 2023

Bundesgesundheitsbl

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ZusammenfassungIm Juli 2013 wurde die erste deutschsprachige Leitlinie zur Behandlung depressiver Störungen bei Kindern und Jugendlichen veröffentlicht. Aktuell befindet sich die Leitlinie in einem Revisionsprozess, in welchem die Empfehlungen erneut betrachtet und aktualisiert werden. In diesem Bericht sollen ein Überblick über den aktuellen Stand sowie ein Ausblick auf die zukünftige Entwicklung der Revision gegeben werden.Innerhalb des Revisionsprozesses wurden die Schlüsselfragen der Erstfassung durch neue Schlüsselfragen erweitert, welche unter anderem den Bereich der ergänzenden Therapien, also Therapien, die zusätzlich zur üblichen Behandlung eingesetzt werden können, sowie den Übergangsbereich vom Jugend- ins Erwachsenenalter abdecken. Zu allen Schlüsselfragen wurden aktualisierende systematische Literaturrecherchen durchgeführt, wobei sowohl randomisierte kontrollierte Studien als auch systematische Übersichtsarbeiten und nicht-kontrollierte Interventionsstudien berücksichtigt wurden. Die Studien wurden daraufhin auf Anwendbarkeit und mögliche Biasrisiken geprüft, sodass Evidenzgrade vergeben werden konnten, welche die Qualität und Relevanz der verfügbaren Evidenz widerspiegeln.In diesem Bericht wird ein kurzer Überblick über die wichtigsten Erkenntnisse, die aus der neuen Evidenzlage geschlossen werden können, gegeben. Während sich im Bereich Psychotherapie keine wesentlichen neuen Erkenntnisse ergaben, hat sich die Evidenzlage zu einigen Antidepressiva geändert. Im Bereich der ergänzenden Therapien wurde vor allem neue Evidenz zu sportlicher Aktivität gefunden. Allgemein ist mit Änderungen an den Empfehlungen zu Erst- und Alternativbehandlungen zu rechnen. Ein Abschluss des Revisionsprozesses und die Veröffentlichung der revidierten Leitlinie sind bis Ende 2023 geplant.

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Omega-3 fatty-acids modulate symptoms of depressive disorder, serum levels of omega-3 fatty acids and omega-6/omega-3 ratio in children. A randomized, double-blind and controlled trial

Cited by 51 publications

References 54 publications

Lipid Profile, Lipoprotein Subfractions, and Fluidity of Membranes in Children and Adolescents with Depressive Disorder: Effect of Omega-3 Fatty Acids in a Double-Blind Randomized Controlled Study

Lipid Profile, Lipoprotein Subfractions, and Fluidity of Membranes in Children and Adolescents with Depressive Disorder: Effect of Omega-3 Fatty Acids in a Double-Blind Randomized Controlled Study

Reconsidering Meat Intake and Human Health: A Review of Current Research

S3-Leitlinie Depressive Störungen im Kindes- und Jugendalter: Wo geht es hin?

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