Omega-3 fatty acids incorporated colloidal systems for the delivery of Angelica gigas Nakai extract

Lee, Jeong-Jun; Park, Ju-Hwan; Lee, Jae-Young; Jeong, Jae Young; Lee, Song Yi; Yoon, In‐Soo; Kang, Wen; Kim, Dae‐Duk; Cho, Hyun‐Jong

doi:10.1016/j.colsurfb.2015.12.047

Cited by 16 publications

(14 citation statements)

References 41 publications

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“…The release patterns of D, DA, and RSV from NPs in PBS were tested ( Figure 4 ). D and DA were used as typical markers of AGN in the release test of our previous studies [ 24 , 26 , 27 , 28 , 29 ]. The cumulative percentage release of D and DA from AGN NPs at 24 h was 31.91 ± 1.34% and 35.44 ± 2.29%, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…AGN Ex was obtained from AGN by the reported methods [ 24 , 26 , 27 , 28 , 29 ]. In short, AGN was dried at 55 °C for 1 day.…”

Section: Methodsmentioning

confidence: 99%

“…For the simultaneous delivery of diverse components of AGN Ex, single nanocarriers considering their different physicochemical characteristics should be designed. In our previous reports [ 24 , 26 , 27 , 28 , 29 ], several pharmaceutical technologies (that is, hot-melt extrusion, microemulsion, electrospraying/electrospinning, and emulsification-solvent evaporation) have been introduced to prepare the formulations of AGN powder or AGN Ex. Of note, polymer matrix-free AGN nanocomposites (NCs) were fabricated by introducing the nanocrystal preparation protocol [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Development of Resveratrol-Loaded Herbal Extract-Based Nanocomposites and Their Application to the Therapy of Ovarian Cancer

et al. 2018

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Resveratrol (RSV) and the ethanol extract of Angelica gigas Nakai (AGN Ex)-based nanoparticles (NPs) were prepared using the nanocrystal concept. AGN/RSV NPs with 224 nm hydrodynamic size, unimodal size distribution, and negative zeta potential values were developed with the emulsification and solvent evaporation techniques. The crystalline properties of AGN Ex and RSV were transformed during the emulsification and solvent evaporation processes, thus, AGN NPs and AGN/RSV NPs exhibited amorphous states. AGN/RSV NPs held up their initial hydrodynamic size after 24 h of incubation in serum-included media. Sustained release profiles (for 5 days) of decursin (D) and decursinol angelate (DA) (the representative markers of AGN Ex) and RSV were observed at normal physiological pH (pH 7.4). In ovarian cancer (SKOV-3) cells, although AGN/RSV NPs showed a lower cellular entry rate rather than AGN NPs, the cellular accumulated amount of AGN/RSV NPs was similar with that of AGN NPs after 4 h of incubation. The antiproliferation efficiency of AGN/RSV NPs group was significantly higher than the AGN Ex, AGN NPs, and AGN NPs + RSV groups in SKOV-3 cells. AGN/RSV NPs can be one of the promising candidates for therapeutic nanoplatforms against ovarian cancers.

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Section: Resultsmentioning

confidence: 99%

“…AGN Ex was obtained from AGN by the reported methods [ 24 , 26 , 27 , 28 , 29 ]. In short, AGN was dried at 55 °C for 1 day.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of Resveratrol-Loaded Herbal Extract-Based Nanocomposites and Their Application to the Therapy of Ovarian Cancer

et al. 2018

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“…Ethanol-extracted AGN (AGNEtOH) yields decursin and decursinol angelate which were screened to elucidate their therapeutic potential by using omega-3 (ω-3)-based ME systems. The chemical substances greatly dissolved in the ω-3 mixture, and approximately 10- and 6-times higher dissolution was possible as compared to water [ 33 ]. The same group developed another formulation to extract the AGN root derivatives for oral delivery.…”

Section: Extraction Of Agnaccs and Effective Formulation Methodsmentioning

confidence: 99%

Natural Korean Medicine Dang-Gui: Biosynthesis, Effective Extraction and Formulations of Major Active Pyranocoumarins, Their Molecular Action Mechanism in Cancer, and Other Biological Activities

et al. 2017

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Angelica gigas Nakai (AGN) is a crucial oriental medicinal herb that grows especially in Korea and the Far-East countries. It contains chemically active compounds like pyranocoumarins, polyacetylenes and essential oils, which might be useful for treatment of several chronic diseases. It has been used for centuries as a traditional medicine in Southeast Asia, but in Western countries is used as a functional food and a major ingredient of several herbal products. The genus Angelica is also known as ‘female ginseng’ due to its critical therapeutic role in female afflictions, such as gynecological problems. However, it is well-documented that the AGN pyranocoumarins may play vital beneficial roles against cancer, neurodisorders, inflammation, osteoporosis, amnesia, allergies, depression, fungi, diabetes, ischemia, dermatitis, reactive oxygen species (ROS) and androgen. Though numerous studies revealed the role of AGN pyranocoumarins as therapeutic agents, none of the reviews have published their molecular mechanism of action. To the best of our knowledge, this would be the first review that aims to appraise the biosynthesis of AGN’s major active pyranocoumarins, discuss effective extraction and formulation methods, and detail the molecular action mechanism of decursin (D), decursinol angelate (DA) and decursinol (DOH) in chronic diseases, which would further help extension of research in this area.

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“…Recently, this molecules has been used as a surfactant for the preparation of microemulsions for oral, nasal and dermal administration using different oil phases such as isopropylmiristate (IPM) (Suppasansatorn et al, 2007), oleoyl polyoxyl-6 glycerides (Labrafil® M 1944 CS) (Wan et al, 2017;Yao et al, 2009), omega-3 fatty acids (Lee et al, 2016), propylene glycol monolaurate (Yao et al, 2009), medium-chain triglyceride (Captex® 300) (Ke et al, 2005) and oleic acid (Benigni et al, 2018;Suppasansatorn et al, 2007;Telò et al, 2017). Using oleic acid as oil phase, we have previously reported the possibility to obtain, for specific oil/smix/water ratio, gel-like microemulsions (Benigni et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Microemulsions based on TPGS and isostearic acid for imiquimod formulation and skin delivery

Pescina

Garrastazu

Favero

et al. 2018

European Journal of Pharmaceutical Sciences

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Imiquimod (IMQ) is an immunostimulant drug topically used for the treatment of actinic keratosis and basal cell carcinoma. IMQ formulation and skin delivery is difficult because of its very low solubility in the most of pharmaceutical excipients and very poor skin penetration properties. The purpose of this study was to develop a microemulsion to optimise imiquimod skin delivery using D-α-tocopherol polyethylene glycol-1000 succinate (TPGS) as surfactant (so as to take advantage of its thickening properties) and isostearic acid as oil phase. This fatty acid was selected since it has demonstrated a good solubilizing power for imiquimod and it has also shown to contribute to its therapeutic activity. We have built pseudo-ternary diagrams using two different co-surfactants (Transcutol® and propylene glycol-PG) in a 1:1 ratio with TPGS and then selected microemulsions in the clear and viscous regions of the diagrams. The systems were characterized in terms of rheology and X-ray scattering; additionally, the capability to promote IMQ skin uptake was evaluated ex-vivo on a porcine skin model. All the formulations selected in the gel-microemulsion regions behaved as viscoelastic solids; X-rays scattering experiments revealed in all cases the presence of an ordered lamellar structure, but with differences in terms of interlamellar distance and flexibility between Transcutol® and PG-containing systems. A higher flexibility and a greater hydrophobic volume, possibly interconnected at some point, was associated to the use of Transcutol® and had an impact on the microemulsion capacity to solubilize IMQ as well as on the capability to enhance drug uptake into the skin. The best performing gel-like microemulsion was composed of ≈ 26% of water, ≈21% of isostearic acid, ≈26% of TPGS and ≈27% of Transcutol® and accumulated, after 6h of contact, 3.0 ± 1.1 µg/cm2 of IMQ. This value is higher than the one reported in the literature for the commercial cream (1.9 ± 0.8 µg/cm2), despite the 4-times lower concentration of the vehicle (13 mg/g for the microemulsion vs 50 mg/g for the commercial cream).

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Omega-3 fatty acids incorporated colloidal systems for the delivery of Angelica gigas Nakai extract

Cited by 16 publications

References 41 publications

Development of Resveratrol-Loaded Herbal Extract-Based Nanocomposites and Their Application to the Therapy of Ovarian Cancer

Development of Resveratrol-Loaded Herbal Extract-Based Nanocomposites and Their Application to the Therapy of Ovarian Cancer

Natural Korean Medicine Dang-Gui: Biosynthesis, Effective Extraction and Formulations of Major Active Pyranocoumarins, Their Molecular Action Mechanism in Cancer, and Other Biological Activities

Microemulsions based on TPGS and isostearic acid for imiquimod formulation and skin delivery

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