Omega-3 fatty acids enhance mitochondrial superoxide dismutase activity in rat organs during post-natal development

Garrel, Catherine; Alessandri, Jean-Marc; Guesnet, Philippe; Al-Gubory, Kaïs Hussain

doi:10.1016/j.biocel.2011.10.007

Cited by 70 publications

(43 citation statements)

References 51 publications

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“…Our study evaluated the activity and protein expression of this enzyme, and we did not observe significant difference when cells were treated with DHA or EPA. Other studies also found no difference in GPx activity using treatment with omega 3 fatty acids in different concentrations and cellular models (Filaire et al 2010;Garrel et al 2012;Kusunoki et al 2013). Taken together, according to the results present herein, EPA may act as an important anti-oxidant supplement when compared with DHA, helping cells to increase their enzymatic anti-oxidant system capacity, with a consequent prevention of cell oxidative damage.…”

Section: Discussionsupporting

confidence: 74%

Omega-3 fatty acids differentially modulate enzymatic anti-oxidant systems in skeletal muscle cells

Silva

Nachbar

Levada‐Pires

et al. 2016

Cell Stress and Chaperones

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During physical activity, increased reactive oxygen species production occurs, which can lead to cell damage and in a decline of individual's performance and health. The use of omega-3 polyunsaturated fatty acids as a supplement to protect the immune system has been increasing; however, their possible benefit to the anti-oxidant system is not well described. Thus, the aim of this study was to evaluate whether the omega-3 fatty acids (docosahexaenoic acid and eicosapentaenoic acid) can be beneficial to the anti-oxidant system in cultured skeletal muscle cells. C2C12 myocytes were differentiated and treated with either eicosapentaenoic acid or docosahexaenoic acid for 24 h. Superoxide content was quantified using the dihydroethidine oxidation method and superoxide dismutase, catalase, and glutathione peroxidase activity, and expression was quantified. We observed that the docosahexaenoic fatty acids caused an increase in superoxide production. Eicosapentaenoic acid induced catalase activity, while docosahexaenoic acid suppressed superoxide dismutase activity. In addition, we found an increased protein expression of the total manganese superoxide dismutase and catalase enzymes when cells were treated with eicosapentaenoic acid. Taken together, these data indicate that the use of eicosapentaenoic acid may present both acute and chronic benefits; however, the treatment with DHA may not be beneficial to muscle cells.

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Section: Discussionsupporting

confidence: 74%

Omega-3 fatty acids differentially modulate enzymatic anti-oxidant systems in skeletal muscle cells

Silva

Nachbar

Levada‐Pires

et al. 2016

Cell Stress and Chaperones

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“…Addition of FFA enhanced the above described effect (Table 1). It was paralleled by the elevated expression of the protective antioxidant enzymes such as GPX3, MT1X, MGST1, GSR, MAOA, and SOD2 (Table 1) [33,34].…”

Section: Resultsmentioning

confidence: 98%

Influence of dietary fatty acids on differentiation of human stromal vascular fraction preadipocytes

Polus

Kieć‐Wilk

Raźny

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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“…Previously it has been reported that supplementation with vitamin E and vitamin C increases the activity of antioxidant enzymes (23). Supplementation with ω-3 fatty acids might also increase antioxidant enzymes activity (24). Although the specifi c biologic mechanism for the benefi cial effects of ω-3 fatty acids on oxidative status has not been fully established, several data indicate that ω-3 fatty acids may play a key role in decreasing the complications of diabetes (25,26).…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamins A, E, C and omega-3 fatty acids supplementation on the level of catalase and superoxide dismutase activities in streptozotocin-induced diabetic rats

Tabei¹,

Fakher²,

Djalali³

et al. 2015

BLL

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Abstract:Background: Since free radicals and antioxidant enzymes may play an important role in the development of diabetes, the present study was designed to assess the effect of supplementation with vitamins A, E and C and ω-3 fatty acids on catalase and superoxide dismutase activity in streptozotocin (STZ)-induced diabetic rats. Methods: A total of 64 male Wistar rats weighing 250 g were divided into four groups as normal control, diabetic control, diabetic supplemented with vitamin A, E and C and diabetic supplemented with ω-3 fatty acids. After four weeks the rats were anesthetized and catalase (CAT) and superoxide dismutase (SOD) activities were investigated in blood samples, liver and heart homogenates. Results: In diabetic rats, the activity levels of heart SOD (p < 0.001) and heart and liver CAT (p < 0.001) were signifi cantly lower than in normal control rats. Supplementation with vitamins A, E and C signifi cantly increased heart CAT (p = 0.05). No signifi cant change was observed in diabetic rats supplemented with ω-3 fatty acids. Conclusion: Supplementation with vitamins A, E and C and ω-3 fatty acids was found to increase heart CAT activity in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes (Tab. 6, Ref. 26). Text in PDF www.elis.sk.

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Omega-3 fatty acids enhance mitochondrial superoxide dismutase activity in rat organs during post-natal development

Cited by 70 publications

References 51 publications

Omega-3 fatty acids differentially modulate enzymatic anti-oxidant systems in skeletal muscle cells

Omega-3 fatty acids differentially modulate enzymatic anti-oxidant systems in skeletal muscle cells

Influence of dietary fatty acids on differentiation of human stromal vascular fraction preadipocytes

Effect of vitamins A, E, C and omega-3 fatty acids supplementation on the level of catalase and superoxide dismutase activities in streptozotocin-induced diabetic rats

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