Omega-3 fatty acids, energy substrates, and brain function during aging

Freemantle, Erika; Vandal, Milène; Tremblay‐Mercier, Jennifer; Tremblay, Sébastien; Blachère, Jean-Christophe; Bégin, Michel E.; Brenna, J. Thomas; Windust, Anthony; Cunnane, Stephen C.

doi:10.1016/j.plefa.2006.05.011

Cited by 141 publications

(82 citation statements)

References 51 publications

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“…Modulating DHA dietary intake may therefore help prevent or correct the glucose hypometabolism observed during agerelated cognitive decline ( 15 ). In vivo PUFA supplementation studies confi rmed the possible relation between 3 PUFA and expression of brain energy metabolism genes including cytochrome-C oxidase, NADH dehydrogenase, and ATP synthetase ( 16 ).…”

Section: Animals and Dietsmentioning

confidence: 96%

Long-chain n-3 PUFAs from fish oil enhance resting state brain glucose utilization and reduce anxiety in an adult nonhuman primate, the grey mouse lemur

Pifferi

Dorieux

Castellano

et al. 2015

Journal of Lipid Research

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Section: Animals and Dietsmentioning

confidence: 96%

Long-chain n-3 PUFAs from fish oil enhance resting state brain glucose utilization and reduce anxiety in an adult nonhuman primate, the grey mouse lemur

Pifferi

Dorieux

Castellano

et al. 2015

Journal of Lipid Research

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“…Although many important functions have been attributed to 22:6n-3 within the brain (2,(76)(77)(78), few studies have attempted to test whether these functions are related to released 22:6n-3. Rats deprived of dietary n-3 PUFAs to reduce brain concentrations have behavioral deficits (79,80), altered neurotransmission (81,82), decreased iPLA 2 activity and expression (47), and decreased 22:6n-3 release from brain phospholipids (75,83).…”

Section: Consequences Of 22:6n-3 Release From Brain Phospholipidsmentioning

confidence: 99%

The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids

Green

Orr

Bazinet

2008

Journal of Lipid Research

105

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Brain phospholipids are highly enriched in docosahexaenoic acid (DHA; 22:6n-3). Recent advances indicate that 22:6n-3 is released from brain phospholipids via the action of phospholipase A 2 (PLA 2 ) in response to several stimuli, including neurotransmission, where it then acts as a secondary messenger. Furthermore, it is now known that released 22:6n-3 is a substrate for several oxygenation enzymes whose products are potent signaling molecules. One emerging candidate PLA 2 involved in the release of 22:6n-3 from brain phospholipids is the group VI calciumindependent phospholipase A 2 (iPLA 2 ). After a brief review of brain 22:6n-3 metabolism, cell culture and rodent studies facilitating the hypothesis that group VI iPLA 2 releases 22:6n-3 from brain phospholipids are discussed. The identification of PLA 2 s involved in cleaving 22:6n-3 from brain phospholipids could lead to the development of novel therapeutics for brain disorders in which 22:6n-3 signaling is disordered.-Green, J. T., S. K. Orr, and R. P. Bazinet. The emerging role of group VI calcium-independent phospholipase A 2 in releasing docosahexaenoic acid from brain phospholipids. J. Lipid Res. 2008. 49: 939-944.

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“…Research over the last 5 years has now clearly established that our learning and memory abilities, as well as our mood, can be influenced by diet, not only during development, but also during adulthood (reviewed in [35]). For example, low intake of omega-3 fatty acids is associated with several forms of cognitive decline in the elderly [31], whereas a diet rich in it is associated with the prevention of cognitive decline [116]. Interestingly, rodents with omega-3 fatty acids deficiency showed impaired performance in spatial memory tasks, which could be rectified after dietary replenishment [26].…”

Section: Introductionmentioning

confidence: 99%

Impact of diet on adult hippocampal neurogenesis

2009

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Research over the last 5 years has firmly established that learning and memory abilities, as well as mood, can be influenced by diet, although the mechanisms by which diet modulates mental health are not well understood. One of the brain structures associated with learning and memory, as well as mood, is the hippocampus. Interestingly, the hippocampus is one of the two structures in the adult brain where the formation of newborn neurons, or neurogenesis, persists. The level of neurogenesis in the adult hippocampus has been linked directly to cognition and mood. Therefore, modulation of adult hippocampal neurogenesis (AHN) by diet emerges as a possible mechanism by which nutrition impacts on mental health. In this study, we give an overview of the mechanisms and functional implications of AHN and summarize recent findings regarding the modulation of AHN by diet.

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Omega-3 fatty acids, energy substrates, and brain function during aging

Cited by 141 publications

References 51 publications

Long-chain n-3 PUFAs from fish oil enhance resting state brain glucose utilization and reduce anxiety in an adult nonhuman primate, the grey mouse lemur

Long-chain n-3 PUFAs from fish oil enhance resting state brain glucose utilization and reduce anxiety in an adult nonhuman primate, the grey mouse lemur

The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids

Impact of diet on adult hippocampal neurogenesis

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