Omega-3 fatty acids as feed supplement modulates blood formation and body weight in Rattus norvegicus model

Nnamonu, Emmanuel Ikechukwu; Mgbenka, Bernard Obialo; Ezewudo, Bede Izuchukwu; Mbegbu, Edmund Chidiebere; Ezechukwu, Chiemekam Samuel; Ugwu, Godwin C.

doi:10.1186/s41936-020-00155-1

Cited by 4 publications

(7 citation statements)

References 35 publications

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“…Although they showed varying values, statistically the WBC components (lymphocytes, monocytes, granulocytes, %lymphocytes, %monocytes, and %granulocytes) did not show a significant difference. This is in accordance with the research of Alia et al ( 2019) and Nnamonu et al (2020) which states that there is no significant difference to the WBC component. The increase in lymphocytes can be related to the release of the hormone epinephrine while the increase in monocytes is associated with phagocytic activity, inflammation, corticosteroids, secondary hemolysis and neoplasia ( Jackson, 2007).…”

Section: White Blood Cells Componentssupporting

confidence: 93%

“…Although the values obtained varied, statistically the components of MCV, MCH, and MCHC did not have a significant difference, which was in accordance with the research of Alia et al ( 2019) and Nnamonu et al (2020). This statement is supported by the research of Babalola et al (2016) which stated that the provision of vegetable oil compared to fish oil did not show significant differences in MCV, MCH and MCHC.…”

Section: Comparison Of Blood Haematological Profilesupporting

confidence: 86%

“…In addition, fish oil contains more Omega 3 in the form of EPA and DHA than Moringa oil which is a vegetable oil (Ayisi, 2021). DHA has an important role in cardiovascular health and spermatogenesis while EPA has anti-inflammatory benefits related to its chemoprotective role in cardiovascular disease by modulating body fat accumulation and reducing fat deposition, one of which is in the heart (Bais et al, 2014;Nnamonu et al, 2020). In this study, the average heart weight in the Omega 3 group was greater than the control and KSO groups.…”

Section: Comparison Of Organ Weightmentioning

confidence: 50%

“…Research by Nnamonu et al (2020) also stated that giving omega 3 from fish oil did not give a significant difference in RBC. This is supported by Asare (2011) which states that there is no difference in RBC after being given vegetable oil as a substitute for fish oil.…”

Section: Comparison Of Blood Haematological Profilementioning

confidence: 99%

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The Comparison of Moringa oleifera Seeds Oil and Fish Oil in Organ Weight and Blood Haematological Profile in Subchronic Male Mice

Hiroyuki¹,

Qomariyuti²,

Islami³

et al. 2022

AAVS

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Livestock productivity can be increased by promoting growth using feed supplements such as fish oil containing omega 3, 6 and 9. These ingredients can also be found in Moringa seed oil which is cheaper and easier to find than fish oil. Omega 3 and 6 can increase dietary palatability thereby increasing feed intake which helps increase body weight which is correlated with organ weight. Based on this, a study was conducted that aims to compare the effect of Moringa seed oil and fish oil on organ weight and blood hematological profiles of mice. The study used 24 male mice of the DDY strain which were divided into three groups, namely the control group (Na-CMC-1%), KSO (moringa seed oil), and Omega-3 (fish oil). Mice were checked for temperature, GDP, and body weight at the beginning and end of the experimental period after 6 weeks. After that, the mice were sacrificed and blood samples were taken for hematological examination and the heart, liver, white fat tissue, and kidneys were weighed. The results showed that the average heart weight (0.120 grams) and white fat tissue (0.145 grams) decreased in the KSO group, as did RBC (8.285×106/μl), WBC (2,943×103/μl) and platelets (506 ,5×103/μl), but statistically there was no significant difference in hematological parameters, body temperature, GDP, body weight and liver and kidney weight p(> 0.05). However, there was a difference in heart weight and white fat tissue p(<0.05). In conclusion, Moringa seed oil can affect organ weight and blood hematological profiles like fish oil, but further research is needed to ensure that Moringa seed oil can be used as an alternative to fish oil substitute feed supplements.

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Section: White Blood Cells Componentssupporting

confidence: 93%

Section: Comparison Of Blood Haematological Profilesupporting

confidence: 86%

Section: Comparison Of Organ Weightmentioning

confidence: 50%

Section: Comparison Of Blood Haematological Profilementioning

confidence: 99%

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The Comparison of Moringa oleifera Seeds Oil and Fish Oil in Organ Weight and Blood Haematological Profile in Subchronic Male Mice

Hiroyuki¹,

Qomariyuti²,

Islami³

et al. 2022

AAVS

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“…The ndings of previous studies on hematological alteration effects of polyunsaturated omega-3 fatty acids as feed supplement have been controversial. Some of these studies have indicated positive effects of oral omega-3 supplements on hematological markers [2][3][4], while others did not nd these effects [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Effect of cold pressed chia seed oil intake on hematological and biochemical biomarkers in both normal and hypercholesterolemic rabbits

Alarcón

Sierra

Roco

et al. 2022

Preprint

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Most of the studies into the beneficial effects of chia were conducted with seeds. However, less evidence about the effects of cold pressed chia seeds oil on hypercholesterolemia-induced alterations has been found. Thus, this study investigated the effects of cold pressed chia seed oil supplementation on some clinical, hematological and biochemical biomarkers in both normal and hypercholesterolemic rabbits. All experimental protocols were approved by the Institutional Animal Ethics Committee (Approval number: 021/2019; Date: March 23th, 2021). 32 male rabbits were assigned to four different groups fed on: regular diet (CD), CD supplemented with 10% chia oil, CD supplemented with 1% cholesterol, CD supplemented with 1% cholesterol and 10% chia oil. After 6 weeks of dietary interventions, mean arterial blood pressure and visceral fat were measured and blood samples were analyzed for lipid profiles and hematological parameters while erythrocyte membranes and retroperitoneal fat were analyzed for fatty acids composition and biochemical biomarkers. Dietary intervention with chia oil reached to control hypercholesterolemia-induced increase of mean arterial blood pressure, neutrophil to lymphocytes ratio, erythrocyte membrane fluidity, and improved erythrocyte morphological alterations. With regard to inflammatory biomarkers, chia oil supplementation reduced omega-6/omega 3 polyunsaturated fatty acids ratio and arachidonic/linolenic fatty acids ratio both in erythrocytes and fat from normal and hypercholesterolemic rabbits. The increase of linolenic fatty acid into the retroperitoneal fat was about 9 times higher than its respective controls. These results provide support for the potential health benefits of the chia oil intake against hypercholesterolemia-associated clinical, hematological and biochemical alterations.

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Growth performance and cost-effectiveness of replacement of fishmeal with plant-based protein source, Leucaena leucocephala in the diet of Clarias gariepinus fingerlings

AGUPUGO

NSOFOR²,

EZEWUDO³

et al. 2022

Asian J Agric

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Abstract. Agupugo CS, Nsofor CI, Ezewudo BI, Edeh IC. 2022. Growth performance and cost-effectiveness of replacement of fishmeal with plant-based protein source, Leucaena leucocephala in the diet of Clarias gariepinus fingerlings. Asian J Agric 6: 28-34. The present study was conducted to determine the effects of replacement of fishmeal with Leucaena leucocephala (Lam.) de Wit leaf meal (0%, 10%, 20% and 30%) on fish growth and to compare the cost-effectiveness of replacement of fishmeal with Leucaena leaf meal in fish diets. The results of the proximate value of the tested leaf meal showed moderate contents of crude protein and low contents of crude ash. The daily and mean weight gains of fish showed that the highest weight gains were recorded in fish fed with diet T3 (20%) while the least values were in fish fed with diet T4 (30%) and the differences were not significant (P>0.05). The highest survival rate was observed in fish fed with diet T1 (0%), while fish fed with diets T2 (10%) and T4 had the least values. The highest specific growth rate was obtained in diet T1. However, the highest food conversion ratio was recorded in fish fed with diet T4. The highest expenditure was recorded in diet T1. Our findings showed that the utilization of Leucaena leaf meal in the fish diet is best at 20% inclusion level for optimum growth. Leucaena-containing diets were more cost-effective than a diet with only fishmeal.

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Omega-3 fatty acids as feed supplement modulates blood formation and body weight in Rattus norvegicus model

Cited by 4 publications

References 35 publications

The Comparison of Moringa oleifera Seeds Oil and Fish Oil in Organ Weight and Blood Haematological Profile in Subchronic Male Mice

The Comparison of Moringa oleifera Seeds Oil and Fish Oil in Organ Weight and Blood Haematological Profile in Subchronic Male Mice

Effect of cold pressed chia seed oil intake on hematological and biochemical biomarkers in both normal and hypercholesterolemic rabbits

Growth performance and cost-effectiveness of replacement of fishmeal with plant-based protein source, Leucaena leucocephala in the diet of Clarias gariepinus fingerlings

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