Omega-3 Fatty Acids Are More Beneficial in the Depressive Phase Than in the Manic Phase in Patients With Bipolar I Disorder

Chiu, Chih Chiang; Huang, Shih‐Yi; Chen, Chiao Chicy; Su, Kuan‐Pin

doi:10.4088/jcp.v66n1219b

Cited by 66 publications

(66 citation statements)

References 1 publication

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“…By contrast, a 4-month, randomized, placebocontrolled trial found no benefit of adjunctive ethyl-EPA 6 g/day over placebo in the treatment of outpatients with bipolar depression (n = 59) or rapid cycling (n = 62) [40]. Another small randomized controlled trial (n = 15) of adjunctive EPA plus DHA in the treatment of acute mania found no benefit over placebo in reducing mania [41]. …”

Section: Resultsmentioning

confidence: 99%

Nutrient-Based Therapies for Bipolar Disorder: A Systematic Review

Sylvia

Peters

Deckersbach

et al. 2012

Psychother Psychosom

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Background: Pharmacotherapy is the first line of treatment for bipolar disorder, but many patients continue to experience persistent subthreshold symptoms. Alternative adjunct treatments, including nutritional therapies, may have the potential to alleviate residual symptoms and improve the outcomes of standard pharmacotherapy. The aim of this paper is to critically review the current clinical evidence and mechanisms of action of nutrient-based therapies alone or in combination with commonly used pharmacotherapies for mania and bipolar depression. Methods: We conducted a Medline search for clinical trials conducted with humans, published in English from 1960 to 2012 using nutritional supplements such as n–3, chromium, inositol, choline, magnesium, folate and tryptophan alone or in combination with pharmacotherapies for the treatment of bipolar disorder. Results: Preliminary data yields conflicting but mainly positive evidence for the use of n–3 fatty acids and chromium in the treatment of bipolar depression. Limited evidence found that inositol may be helpful for bipolar depression, but larger sample sizes are needed. Preliminary randomized, controlled trials suggest that choline, magnesium, folate and tryptophan may be beneficial for reducing symptoms of mania. Conclusions: Given the potential public health impact of identifying adjunct treatments that improve psychiatric as well as physical health outcomes, nutritional treatments appear promising for the management of bipolar disorder but require further study.

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Section: Resultsmentioning

confidence: 99%

Nutrient-Based Therapies for Bipolar Disorder: A Systematic Review

Sylvia

Peters

Deckersbach

et al. 2012

Psychother Psychosom

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“…Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have a range of neurobiological activities that contribute to their potential antidepressant effects, 2 which have been supported by recent well-conducted randomized controlled trials (RCTs). [3][4][5][6] However, the effect sizes of omega-3 PUFAs for MDD are also modest. 3 To improve the clinical application, it is important to "stratify" MDD for specific therapies, which is so-called personalized medicine.…”

Section: Personalized Medicine With Omega-3 Fatty Acids For Depressiomentioning

confidence: 99%

Personalized Medicine With Omega-3 Fatty Acids for Depression in Children and Pregnant Women and Depression Associated With Inflammation

Su¹

2015

J. Clin. Psychiatry

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“…71 Three open-label trials have found adjunctive omega-3 fatty acid supplementation to be effective in bipolar disorder (Table 3). [72][73][74][75][76][77][78][79][80] The two studies in pediatric patients with bipolar disorder both reported improvement in manic symptoms, one of which reported improvements in depression when omega-3 fatty acids were added to ongoing treatment. 70,79 The one open-label adult trial reported significant improvement in depressive symptoms when omega-3 fatty acids were added to ongoing treatment.…”

Section: Bipolar Disordermentioning

confidence: 99%

“…[72][73][74]76,77 Two negative trials studied omega-3 fatty acid supplementation in subpopulations (acute mania, women discontinuing mood stabilizers prior to becoming pregnant), making it difficult to generalize the findings. 72,76 Both positive trials reported significant improvement in depressive symptoms but no benefit for mania, suggesting omega-3 fatty acids may play a limited role in adult bipolar disorder. 73,77 The one randomized controlled trial on pediatric bipolar disorder reported no benefit with ALA supplementation.…”

Section: Bipolar Disordermentioning

confidence: 99%

The Use of Omega-3 Fatty Acids in Mental Illness

Gören

Tewksbury

2011

Journal of Pharmacy Practice

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Purpose: This article will summarize the current evidence on the effects of omega-3 fatty acids on prevention and treatment of mental illness. Background: Omega-3 fatty acids are involved in many physiologic processes. Since they cannot be made de novo in the body, they are considered essential nutrients. As the Western diet evolved, dietary intake of fatty acids has shifted to increased omega-6 fatty acids and decreased omega-3 fatty acids intake. These changes have been correlated with numerous differences in prevalence and course of mental illnesses. Methods: A MEDLINE search from 1966 to December 2010 was completed to identify studies comparing changes in symptoms, functioning, other outcomes, and/or side effects in patients treated with omega-3 fatty acids for mental illness. The studies were reviewed and reported by specific psychiatric disorder studied. Conclusions: Omega-3 fatty acids play a role in many biologic functions. Epidemiologic data implicate omega-3 fatty acid deficiencies in many mental illnesses. Data are most robust for omega-3 fatty acids' role in affective disorders. However, data are conflicting, negative, or absent for most mental illnesses.

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Omega-3 Fatty Acids Are More Beneficial in the Depressive Phase Than in the Manic Phase in Patients With Bipolar I Disorder

Cited by 66 publications

References 1 publication

Nutrient-Based Therapies for Bipolar Disorder: A Systematic Review

Nutrient-Based Therapies for Bipolar Disorder: A Systematic Review

Personalized Medicine With Omega-3 Fatty Acids for Depression in Children and Pregnant Women and Depression Associated With Inflammation

The Use of Omega-3 Fatty Acids in Mental Illness

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