2014
DOI: 10.3389/fendo.2014.00115
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Omega-3 Fatty Acids and FFAR4

Abstract: The beneficial roles of omega-3 fatty acids (ω3-FAs) on obesity, type 2 diabetes, and other metabolic diseases are well known. Most of these effects can be explained by their anti-inflammatory effects triggered through their receptor, free fatty acid receptor 4 (FFAR4) activation. Although the whole mechanism of action is not fully described yet, it has been shown that stimulation of ω3-FA to FFAR4 is followed by receptor phosphorylation. This makes FFAR4 to be capable of interacting with β-arrestin-2, which i… Show more

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Cited by 35 publications
(29 citation statements)
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References 63 publications
(105 reference statements)
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“…The results showed that omega-3 played a role in glucose homeostasis [34]. In the study conducted by Oh and Walenta in 2014 it was indicated the omega-3 fish oil fatty acid had beneficial effects on obesity and glucose homeostasis whose effects were mostly due to its antiinflammatory properties exerted through affecting its receptor (free fatty acid receptor 4 (FFAR4)) [35]. The study done by Feillet-Coudray et al in 2013 showed that a diet rich in omega-3 fatty acids stabilized and improved sensitivity to insulin [36].…”
Section: Discussionmentioning
confidence: 99%
“…The results showed that omega-3 played a role in glucose homeostasis [34]. In the study conducted by Oh and Walenta in 2014 it was indicated the omega-3 fish oil fatty acid had beneficial effects on obesity and glucose homeostasis whose effects were mostly due to its antiinflammatory properties exerted through affecting its receptor (free fatty acid receptor 4 (FFAR4)) [35]. The study done by Feillet-Coudray et al in 2013 showed that a diet rich in omega-3 fatty acids stabilized and improved sensitivity to insulin [36].…”
Section: Discussionmentioning
confidence: 99%
“…[44] Besides, the incorporation of DHA to the lipid membrane disrupts the signaling of toll-like receptor 4 (TLR-4) by impeding its translocation to the lipid raft, and inhibiting the signaling pathway of MD2/TRIAP-MyD88/IRAK-TRAF6/IKKβ [41,46,47] [ Figure 2]. Also, EPA and DHA cause the down-regulation of nicotinamide adenine dinucleotide phosphateoxidase, which induces the production of reactive oxygen species, a requirement for TLR-4 signaling.…”
Section: Chronic Pro-inflammatory Statesmentioning
confidence: 99%
“…We, in the present study, have then verified the potential of one of such upregulated GPCRs in lesions, GPR120, as a therapeutic target because GPR120, a receptor of ω3 fatty acids, could inhibit NF-κB activation [11]. Stimulation of GPR120 with its ligand induces the formation of the GPR120/β-arrestin-2 complex and then β-arrestin-2 traps transforming growth factor-β (TGF-β) activated kinase 1 binding protein (TAB1), leading to the inhibition of TGF-β activated kinase 1(TAK1) which activates inhibitor of κB kinase subunit β (IKKβ) [11,12].…”
Section: Introductionmentioning
confidence: 99%