Omega-3 fatty acids ameliorate cognitive dysfunction in schizophrenia patients with metabolic syndrome

Tang, Wei; Wang, Yewei; Xu, Fang; Fan, Weixing; Zhang, Yaoyao; Fan, Kaili; Wei-ping, Wang; Zeng, Yi; Zhang, Chen

doi:10.1016/j.bbi.2020.04.034

Cited by 50 publications

(30 citation statements)

References 42 publications

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“…Clinical trials showed the ability of omega-3 PUFAs to reduce clinical symptoms of schizophrenia [31,32]. We did not find any differences in PUFA concentration and intake between schizophrenia patients and healthy individuals.…”

Section: Discussioncontrasting

confidence: 51%

The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia

et al. 2020

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A growing body of evidence confirms abnormal fatty acid (FAs) metabolism in the pathophysiology of schizophrenia. Omega-3 polyunsaturated fatty acids (PUFAs) are endogenous ligands of the G protein-coupled receptors, which have anti-inflammatory properties and are a therapeutic target in many diseases. No clinical studies are concerned with the role of the GPR120 signaling pathway in schizophrenia. The aim of the study was to determine the differences in PUFA nutritional status and metabolism between patients with schizophrenia (SZ group) and healthy individuals (HC group). The study included 80 participants (40 in the SZ group, 40 in the HC group). There were no differences in serum GPR120 and PUFA concentrations and PUFA intake between the examined groups. In the HC group, there was a relationship between FAs in serum and GPR120 concentration (p < 0.05): α-linolenic acid (ALA) (R = −0.46), docosahexaenoic acid (DHA) (R = −0.54), omega-3 PUFAs (R = −0.41), arachidonic acid (AA) (R = −0.44). In the SZ group, FA serum concentration was not related to GPR120 (p > 0.05). In the HC group, ALA and DHA serum concentrations were independently associated with GPR120 (p < 0.05) in the model adjusted for eicosapentaenoic acid (EPA) and accounted for 38.59% of GPR120 variability (p < 0.05). Our results indicate different metabolisms of FAs in schizophrenia. It is possible that the diminished anti-inflammatory response could be a component connecting GPR120 insensitivity with schizophrenia.

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Section: Discussioncontrasting

confidence: 51%

The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia

et al. 2020

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“…Previous findings [62] showed that omega-3 fatty acids have beneficial effects on triglycerides in patients with psychotic symptoms and metabolic syndrome and may enhance the brain-derived neurotrophic factor (BDNF) levels through their anti-inflammatory properties with a reduction of cognitive dysfunction in these patients [63]. Probably, an appropriate dietary supplementation could play a partially therapeutic effect even in more severe patients, improving some behavioral aspects and reducing the cognitive deterioration [64]. In addition, EPA supplementation was found to be associated with a marked increase of glutathione, an antioxidant agent, in patients with first episode of psychosis.…”

Section: Psychotic Symptomsmentioning

confidence: 99%

Effects of Omega 3 Fatty Acids on Main Dimensions of Psychopathology

Bozzatello

Rosa

Rocca

et al. 2020

IJMS

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The usefulness of polyunsaturated fatty acids on inflammatory, cardiovascular, and the nervous system was studied in the last decades, but the mechanisms underlying their benefic properties are still partially unknown. These agents seem to express their action on the membrane phospholipid composition and permeability and modulation of second messenger cascades. In psychiatry, the efficacy and tolerability of omega-3 fatty acids were investigated in several psychiatric disorders, including major depression, bipolar disorder, personality disorders, high-risk conditions to develop psychosis, attention-deficit hyperactivity disorder, and autism spectrum disorders. Initial findings in this field are promising, and some relevant questions need to be addressed. In particular, the effects of these agents on the main symptom dimensions have to be investigated in a trans-diagnostic perspective. The present systematic review is aimed to examine the available data on the efficacy of omega-3 fatty acids on domains of psychotic symptoms, affective symptoms, impulsivity, and aggressiveness, and harmful behaviors, and suicide risk.

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“…Animal studies have confirmed Omega-3 fatty acid provides cell signaling intermediate (specialized pro-resolving mediators) precursors for inflammation resolution in the adipose tissue microenvironment and elevates insulin sensitivity in the condition of MetS ( Carracedo et al, 2019 ; Kwon, 2020 ). In human trials, it was also reported to assist with facilitate cognitive dysfunction in MetS patients by enhancing brain-derived neurotrophic factors ( Tang et al, 2020 ). More discoveries of acting mechanisms and finding the sub-population of MetS that would benefit from its intake would be unveiled by more big data studies based on omics and other data sources.…”

Section: Interventions For Mets Supported By “Big Data” Approachesmentioning

confidence: 99%

“Big Data” Approaches for Prevention of the Metabolic Syndrome

et al. 2022

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Metabolic syndrome (MetS) is characterized by the concurrence of multiple metabolic disorders resulting in the increased risk of a variety of diseases related to disrupted metabolism homeostasis. The prevalence of MetS has reached a pandemic level worldwide. In recent years, extensive amount of data have been generated throughout the research targeted or related to the condition with techniques including high-throughput screening and artificial intelligence, and with these “big data”, the prevention of MetS could be pushed to an earlier stage with different data source, data mining tools and analytic tools at different levels. In this review we briefly summarize the recent advances in the study of “big data” applications in the three-level disease prevention for MetS, and illustrate how these technologies could contribute tobetter preventive strategies.

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Omega-3 fatty acids ameliorate cognitive dysfunction in schizophrenia patients with metabolic syndrome

Cited by 50 publications

References 42 publications

The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia

The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia

Effects of Omega 3 Fatty Acids on Main Dimensions of Psychopathology

“Big Data” Approaches for Prevention of the Metabolic Syndrome

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