Omega-3 and Omega-6 Polyunsaturated Fatty Acids in Bipolar Disorder

Saunders, Erika F.H.; Ramsden, Christopher E.; Sherazy, Mostafa S.; Gelenberg, Alan J.; Davis, John M.; Rapoport, Stanley I.

doi:10.4088/jcp.15r09925

Cited by 41 publications

(33 citation statements)

References 54 publications

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“…Thus, blueberry juice significantly improved word list recall and paired associate learning in older men and women with agerelated memory decline that consumed it, relative to baseline, with paired associate learning also significantly improved relative to placebo controls. 97 A recent study 98 that measured similar cognitive tasks as those in the rodent studies, showed that freezedried blueberries (24 g/day, equivalent to one cup of fresh blueberries) for 90 days improved two measures of executive function in older adults (ages [60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75]. Participants in the blueberry group showed significantly fewer repetition errors in the California Verbal Learning test as well as reduced switch cost on a taskswitching test across study visits, relative to controls who consumed placebo powder.…”

Section: Dietary Interventions With Polyphenolic-rich Foods Can Impromentioning

confidence: 98%

“…62 Abnormal omega-3 PUFA levels have been extensively described in both the peripheral tissues and in the brain of patients with mood disorders or cognitive decline, leading to a large number of RCTs aiming at evaluating the effectiveness of long chain omega-3 PUFA dietary supplementation on mood and cognitive disorders. 58,63 Overall, the results are discordant, due to the heterogeneity of methods used to evaluate the depressive and/or cognitive symptoms, the form, dose and duration of the omega-3 PUFA supplementation, the lack of evaluation of nutritional intake and metabolism of PUFA prior to starting the supplementation, or the lack of evaluation of genotype-associated risk factors. 64 However, despite the discrepancies in the results, it is important to note that several RCTs performed in patients with depressive disorders revealed an additional effect of long chain omega-3 PUFA supplementation to antidepressant treatments.…”

Section: Dietary Omega-3 Pufa Regulate Neuroinflammation and Ecbs: Romentioning

confidence: 99%

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Food for thought: how nutrition impacts cognition and emotion

et al. 2017

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More than one-third of American adults are obese and statistics are similar worldwide. Caloric intake and diet composition have large and lasting effects on cognition and emotion, especially during critical periods in development, but the neural mechanisms for these effects are not well understood. A clear understanding of the cognitive-emotional processes underpinning desires to over-consume foods can assist more effective prevention and treatments of obesity. This review addresses recent work linking dietary fat intake and omega-3 polyunsaturated fatty acid dietary imbalance with inflammation in developing, adult, and aged brains. Thus, early-life diet and exposure to stress can lead to cognitive dysfunction throughout life and there is potential for early nutritional interventions (e.g., with essential micronutrients) for preventing these deficits. Likewise, acute consumption of a high-fat diet primes the hippocampus to produce a potentiated neuroinflammatory response to a mild immune challenge, causing memory deficits. Low dietary intake of omega-3 polyunsaturated fatty acids can also contribute to depression through its effects on endocannabinoid and inflammatory pathways in specific brain regions leading to synaptic phagocytosis by microglia in the hippocampus, contributing to memory loss. However, encouragingly, consumption of fruits and vegetables high in polyphenolics can prevent and even reverse age-related cognitive deficits by lowering oxidative stress and inflammation. Understanding relationships between diet, cognition, and emotion is necessary to uncover mechanisms involved in and strategies to prevent or attenuate comorbid neurological conditions in obese individuals.

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Section: Dietary Interventions With Polyphenolic-rich Foods Can Impromentioning

confidence: 98%

Section: Dietary Omega-3 Pufa Regulate Neuroinflammation and Ecbs: Romentioning

confidence: 99%

Food for thought: how nutrition impacts cognition and emotion

et al. 2017

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“…30,32 Studies of peripheral PUFA markers in BD show converging findings that abnormalities in the n-6 and n-3 metabolism pathways are present in BD. 33–40 …”

Section: Polyunsaturated Fatty Acids and Neuroinflammationmentioning

confidence: 99%

“…33,69 Briefly, open-label and non-randomized trials have been largely positive, 70–74 while in 5/7 individual randomized clinical trials (RCTs), the intervention group did not separate from placebo for treatment of depression or mania. 75–81 A meta-analysis of RCTs in BD showed a signal for treatment of BD depression, but not mania.…”

Section: Pharmacotherapy In Bd: Anti-inflammatory and N-3 Pufa Agentsmentioning

confidence: 99%

Reconsidering Dietary Polyunsaturated Fatty Acids in Bipolar Disorder: A Translational Picture

Saunders

Ramsden

Sherazy

et al. 2016

J. Clin. Psychiatry

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Inflammation is an important mediator of pathophysiology in bipolar disorder (BD). The omega (n)-3 and omega (n)-6 polyunsaturated fatty acid (PUFA) metabolic pathways participate in several inflammatory processes, and have been linked through epidemiological and clinical studies to BD and its response to treatment. We review the proposed role of PUFA metabolism in neuroinflammation, modulation of brain PUFA metabolism by antimanic medications in rodent models, and anti-inflammatory pharmacotherapy in BD and in major depressive disorder (MDD). Though the convergence of findings between pre-clinical and post-mortem clinical data is compelling, we investigate why human trials of PUFA as treatment are mixed. We view the biomarker and treatment study findings in light of the evidence for the hypothesis that arachidonic acid (AA) hypermetabolism contributes to BD pathophysiology, and propose that a combined high n-3 plus low n-6 diet should be tested as an adjunct to current medication in future trials.

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“…Much evidence has shown that n-3 PUFA may be critical to preventing cardiovascular diseases, diabetes and cancers because of antioxidation and anti-inflammatory activities. High n-6 PUFA consumption is associated with the development of cancers and diseases [2,5,7]. Therefore, the consumption of n-3 PUFAs is positive impact of preventing disease.…”

Section: Introductionmentioning

confidence: 99%

The Pharmacological Effect of Omega-3 Fatty Acids Prevent Cancer Progression in Colon and Breast Cancer

Cm¹

2017

Austin J Nutri Food Sci

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Breast cancer and colon cancer are the common cancers in the world. Dietary fatty acids, n-3 polyunsaturated fatty acids (PUFAs), are believed to play an important role in preventing cancers. Studies have shown that long-chain n-3 PUFAs, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are able to inhibit and prevent cancers. The present review evaluates DHA and EPA the role in the prevention of breast cancer and colon cancer. Further, anticancer mechanisms of action of DHA and EPA are also examined.Method: This review gathers the information from electronic and scientific literature database such as Pubmed, and Science Direct and so on. In this review, we focus on the pharmacological effects of DHA and EPA in breast cancer and colon cancer. Conclusion:This review suggests that n-3 PUFAs have anticancer effects and beneficial to human health.

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Omega-3 and Omega-6 Polyunsaturated Fatty Acids in Bipolar Disorder

Cited by 41 publications

References 54 publications

Food for thought: how nutrition impacts cognition and emotion

Food for thought: how nutrition impacts cognition and emotion

Reconsidering Dietary Polyunsaturated Fatty Acids in Bipolar Disorder: A Translational Picture

The Pharmacological Effect of Omega-3 Fatty Acids Prevent Cancer Progression in Colon and Breast Cancer

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