Omalizumab in severe asthma and food allergies with <scp>IgE</scp> levels &gt;1500 <scp>kU</scp>/L: <scp>Two‐year</scp> evaluation

Dinardo, Giulio; Cafarotti, Arianna; Galletta, Francesca; Fiocchi, Alessandro; Arasi, Stefania

doi:10.1111/pai.14057

Cited by 9 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of cross-contamination as a source of inadvertent allergic food intake is unclear [ 8 ]. People with food allergies can respond to trace levels of the offending food, while there is a wide range of threshold dosages across food allergy groups [ 13 , 14 , 15 ]. Allergic reactions to these impurities can be varied, ranging from mild symptoms such as itching and hives to severe anaphylactic responses.…”

Section: Introductionmentioning

confidence: 99%

“…Allergic reactions to these impurities can be varied, ranging from mild symptoms such as itching and hives to severe anaphylactic responses. Epidemiological studies and case series quantify this risk at 20–40% of people suffering from allergies, so reactions to food traces is not uncommon [ 13 , 16 ]. The potential life-threatening nature of these reactions necessitates a comprehensive examination of the allergenic potential of botanical impurities to safeguard public health.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Botanical Impurities in the Supply Chain: A New Allergenic Risk Exacerbated by Geopolitical Challenges

Dinardo,

Dahdah,

Cafarotti

et al. 2024

Nutrients

Self Cite

View full text Add to dashboard Cite

Background: The supply chains of food raw materials have recently been heavily influenced by geopolitical events. Products that came from, or transited through, areas currently in conflict are now preferentially supplied from alternative areas. These changes may entail risks for food safety. Methods: We review the potential allergenicity of botanical impurities, specifically vegetable contaminants, with particular attention to the contamination of vegetable oils. We delve into the diverse types of botanical impurities, their sources, and the associated allergenic potential. Our analysis encompasses an evaluation of the regulatory framework governing botanical impurities in food labeling. Results: Unintended plant-derived contaminants may manifest in raw materials during various stages of food production, processing, or storage, posing a risk of allergic reactions for individuals with established food allergies. Issues may arise from natural occurrence, cross-contamination in the supply chain, and contamination at during production. The food and food service industries are responsible for providing and preparing foods that are safe for people with food allergies: we address the challenges inherent in risk assessment of botanical impurities. Conclusions: The presence of botanical impurities emerges as a significant risk factor for food allergies in the 2020s. We advocate for regulatory authorities to fortify labeling requirements and develop robust risk assessment tools. These measures are necessary to enhance consumer awareness regarding the potential risks posed by these contaminants.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Botanical Impurities in the Supply Chain: A New Allergenic Risk Exacerbated by Geopolitical Challenges

Dinardo,

Dahdah,

Cafarotti

et al. 2024

Nutrients

Self Cite

View full text Add to dashboard Cite

show abstract

“…Omalizumab was successful in reducing asthma symptoms as measured by the ACT score and in raising spirometry readings after two years of medication; no patient had asthma exacerbations or required ER visits. Furthermore, during the oral food challenge test (OFC), all individuals with food allergies successfully managed to develop “desensitization” to the triggering food ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Omalizumab for the reduction of allergic reactions to foods: a narrative review

Ghouri,

Habib,

Nazir

et al. 2024

Front. Allergy

View full text Add to dashboard Cite

The frequency of food allergies varies between 2% and 10%, depending on characteristics including age, region, race, and method of diagnosis self-reported by patients or oral food challenges (OFCs). The most common allergies reported are tree nuts (1.2%), milk (1.9%), peanuts (2.2%), and shellfish (1.3%). Omalizumab injection has now been approved by the FDA for the treatment of immunoglobulin E-mediated food allergies in specific adults and children aged one year or older. This medication reduces the risk of allergic reactions (Type I), which can include anaphylaxis, when an individual accidentally encounters one or more food allergens. Omalizumab functions by binding to IgE and altering IgE-mediated pathways, which lessens IgE's capacity to cause allergic reactions. Promising outcomes from clinical trials and case studies include lowered anaphylactic risk and enhanced tolerance to allergens. Omalizumab, however, may have adverse effects; thus, close observation is required. Overall, this review sheds light on the efficacy, safety, and clinical implications of omalizumab, highlighting its potential as a useful intervention for IgE-mediated food allergies.

show abstract