The production of middle-season rice is an important part of agriculture in the Yangtze River basin of China. In recent years, the chalky grain rate of middle-season rice has decreased with the release of new cultivars. However, limited information is available on the factors responsible for this change in the chalky grain rate. This study evaluated the trends in the chalky grain rate and grain size traits of the new cultivars and the relationships between the chalky grain rate and grain size traits for middle-season hybrid rice in a province located in the middle reaches of the Yangtze River basin during 2006–2021. The results indicate that the recently reduced chalky grain rate of middle-season hybrid rice in the new cultivars is closely associated with a decrease in rice width, suggesting that it is feasible to reduce the chalky grain rate of middle-season hybrid rice by slimming the grain through breeding.