Olive oil prevents benzo(a)pyrene [B(a)P]-induced colon carcinogenesis through altered B(a)P metabolism and decreased oxidative damage in ApcMin mouse model

Abstract

Colon cancer ranks third in cancer related mortalities in the United States. Many studies have investigated factors that contribute to colon cancer in which dietary and environmental factors have been shown to play an integral role in the etiology of this disease. Specifically, human dietary intake of environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs) has generated interest in looking at how it exerts its effects in gastrointestinal carcinogenesis. Therefore, the objective of this study was to investigate the preventative effects of olive oil on benzo(a)pyrene [B(a)P]-induced colon carcinogenesis in adult ApcMin mice. Mice were assigned to a control (n =8) or treatment group (n =8) consisting of 25, 50 and 100 μg B(a)P/kg body weight (bw) dissolved in tricaprylin [B(a)P-only group] or olive oil daily via oral gavage for sixty days. Our studies showed that ApcMin mice exposed to B(a)P developed a significantly higher number (p< 0.05) of larger dysplastic adenomas compared to those exposed to B(a)P + olive oil. Treatment of mice with B(a)P and olive oil significantly altered (p< 0.05) the expression of drug metabolizing enzymes in both the colon and liver tissues. However, only GST activity was significantly higher (p< 0.05) in the liver of mice treated with 50 and 100 μg B(a)P/kg bw + olive oil. Lastly, olive oil promoted rapid detoxification of B(a)P by decreasing its organic metabolite concentrations and also decreasing the extent of DNA damage to colon and liver tissues (p< 0.05). These results suggest that olive oil has a protective effect against B(a)P-induced colon tumors.

Modulation of intestinal epithelium homeostasis by extra virgin olive oil phenolic compounds

“…130 In addition, EVOOP, including phenolic alcohols, lignans and secoiridoids, are thought to be, in part, responsible for EVOO reported anti-carcinogenic effects. 131 EVOOP have been shown to influence carcinogenesis and tumor development at various levels: [132][133][134] by exerting antioxidant activities, 135,136 by modulating detoxification enzyme systems, 137 and the immune system, 138 by reacting with activated carcinogens and mutagens, 139,140 and by exerting actions on proteins controlling cell cycle progression, 122,141,142 and gene expression. 143,144 The ability of EVOO to inhibit colon cancer development has been demonstrated in large intestinal cancer cell models, 122,144,145 in animals 140,146 and in humans.…”

Olive Oil‐Based Ultrafine Theranostic Photo Nanoemulsions: A Versatile Tumor Maneuvering Nanoplatform for Precise Controlled Drug Release in Tumor and Complete Tumor Eradication Mediated by Photo‐Chemotherapy

“…Though there have been many encapsulating agents available, none of them would be proper for controlling the therapeutics once it is co-loaded with the NIR dyes. [11] Recent report suggests that Adv bio-resorbable extra virgin olive oil (EVO) has anticancer effects owing to their oleocanthal components, [12] thus we explored EVO based NEMSn to encapsulate IR-780 dye along with chemotherapy agent, doxorubicin (DOX) stabilized by Tween-20, and the hyaluronic acid (HA) to impart both thermal and chemo effects on the cancer cells. Nanoemulsions (NEMSn) are the nano version of ordinary micro emulsions, which contains oily and watery part, stabilized by a surfactant.…”

Farelerde AK27 Bitkisel Karışımının Ehrlich Ascites Karsinoma Üzerine Antitümorijenik Etkisi

“…It has been also shown the growth of breast, prostate, colon and lung cancer cells in culture were successfully and selectively inhibited by pomegranate (Punica granatum) extracts [20] . Olive oil phenols as chemopreventive and therapeutic effects against cancer has been reviewed [21,22] and shown that olive oil prevented experimentally induced colon cancer in a mouse model [23] .…”