Olive oil nanoemulsion preparation using high-pressure homogenization and d-phase emulsification – A design space approach

Yukuyama, Megumi Nishitani; Kato, Edna Tomiko Myiake; Araujo, Gabriel Lima Barros de; Löbenberg, Raimar; Monteiro, Lis Marie; Lourenço, Felipe Rebello; Bou‐Chacra, Nádia Araci

doi:10.1016/j.jddst.2018.12.029

Cited by 41 publications

(21 citation statements)

References 27 publications

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“…Under suitable homogenization conditions, the final droplet size depends strongly on the characteristics of the oil and emulsifier used [ 34 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. In general, small droplet sizes can be obtained more effectively by low-energy approaches than by high-energy approaches, but the former are more limited in the types of oils and emulsifiers that can be used [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

Formulation and Preparation of Water-In-Oil-In-Water Emulsions Loaded with a Phenolic-Rich Inner Aqueous Phase by Application of High Energy Emulsification Methods

Niknam

Escudero

Benito

2020

Foods

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Currently, industry is requesting proven techniques that allow the use of encapsulated polyphenols, rather than free molecules, to improve their stability and bioavailability. Response surface methodology (RSM) was applied in this work to determine the optimal composition and operating conditions for preparation of water-in-oil-in-water (W/O/W) emulsions loaded with phenolic rich inner aqueous phase from olive mill wastewater. A rotor-stator mixer, an ultrasonic homogenizer and a microfluidizer processor were tested in this study as high-energy emulsification methods. Optimum results were obtained by means of microfluidizer with 148 MPa and seven cycles input levels yielding droplets of 105.3 ± 3.2 nm in average size and 0.233 ± 0.020 of polydispersity index. ζ-potential, chemical and physical stability of the optimal W/O/W emulsion were also evaluated after storage. No droplet size growth or changes in stability and ζ-potential were observed. Furthermore, a satisfactory level of phenolics retention (68.6%) and antioxidant activity (89.5%) after 35 days of storage at room temperature makes it suitable for application in the food industry.

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Section: Resultsmentioning

confidence: 99%

Formulation and Preparation of Water-In-Oil-In-Water Emulsions Loaded with a Phenolic-Rich Inner Aqueous Phase by Application of High Energy Emulsification Methods

Niknam

Escudero

Benito

2020

Foods

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“…Other experiments formulated an olive oil nanoemulsion had an average particle size of 275 nm with a pressure of 450 bar in 4 cycles using HPH. High-pressure homogenizer method is very effective for reducing the particle sizes of colloidal dispersions [38,39].…”

Section: Resultsmentioning

confidence: 99%

Celastrol Nanoemulgel Formulation and in Vitro Penetration Test

Abdullah

Jufri

Mun’im

et al. 2020

Int J Pharm Pharm Sci

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Objective: To obtain formulations of Celastrol (Cst) nanoemulgel via transdermal route. Celastrol is classified in BCS 4 class as an anti-inflammatory drug. These routes are considered to reduce the risk of Celastrol side effects and have the same characteristics as skin morphology. Methods: Celastrol nanoemulgel was prepared by a high-pressure homogenizer (HPH) technique. To find the optimum nanoemulsion area by using the Chemix 7.00 ternary phase program. Celastrol nanoemulgel was evaluated by measuring the particle size, PDI, morphology, zeta potential, stability tests and in vitro using Franz diffusion cell Results: Results showed the ideal formula based on the ternary phase diagram using chemix 7.00 is oil: smix: water (5:45:50), with particle size 89.9±5 nm, PDI 0.1, and zeta-21 mV. The morphological shape is quite spherical ≤ 100±5 nm. The pH value of this formula is 4.5, which compatible with the pH of the skin. The highest recovery rate of Celastrol and encapsulation efficiency (EE) were formulas 3 μg/ml and 5 μg/ml, with EE 91.70% and 94.54%, respectively. In vitro test results showed that the formula 3 μg/ml and 5 μg/ml give better penetration results than the formula 2.5 μg/ml. Thus, Celastrol nanoemulgel formula has good potential to be developed as a transdermal anti-inflammatory drug. Conclusion: Transdermal nanoemulgel containing Celastrol has been successfully developed with particle size ≤ 200±2 nm.

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“…Olive oil demonstrated anti‐inflammatory activity [19] and protection from UV‐B damage [20], and showed to be an effective nanocarrier [21]. These properties are mainly attributed to the association of monounsaturated oleic acid (C 18:1 chain) which is present in high amounts and small presence of carotenoids and phenolics [22, 23]. Recent studies using shampoo and conditioner containing Abyssinian oil, rich in erucic acid (C 22 chain), showed improved conditioning and removal of sebum [24], treatment effect on scalp dryness and curly hair [25], and better detangling ability, shine, anti‐frizz and combability when applied as hair oil [26].…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsions containing plant oils: How do they influence hair treatment?

Tamashiro

Yukuyama

Velasco

et al. 2020

Intern J of Cosmetic Sci

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Objective Cosmetic and dermatological products, mainly the hair treatments, are projected to have remarkable growing in coming years. Nanotechnology, specifically nanoemulsions, has potential to be used in several hair products, owing to their beneficial properties. Concurrently, plant‐derived cosmetics have become more popular over the years to consumers who prefer a safer, natural and sustainable approach. There is a lack of studies combining plant oils and nanotechnology for haircare formulations. In this work, different plant oil‐loaded nanoemulsions were prepared to investigate the influence of their particle size, zeta potential and composition on hair treatment efficacy. Methods Coconut, olive and Abyssinian oils, alone or in combination, were loaded into nanoemulsions by high‐pressure homogenization method (HPH). The mean particle size, polydispersity index and zeta potential were measured by the dynamic light scattering (DLS) method, and a stability test was performed for five months. A sensorial screening evaluation performed by the analyst and the combing test using Dia‐Stron® instrumentation were applied on hair tresses treated by these nanoemulsions. Results The use of different plant oils for nanoemulsion resulted in distinct final particle sizes and zeta potential. However, results suggested no significant difference between them in hair tresses combing efficacy compared by Dia‐Stron® instrument testing. Moreover, the plant‐loaded nanoemulsions with increased concentration of cationic surfactant indicated a 50% reduction in combing force using this device when compared to control, in addition to better sensory results by screening test compared to other nanoemulsions and control. Conclusion The composition of plant oils, particle size or zeta potential of the prepared nanoemulsions does not seem to significantly influence hair performance. Thus, we suggest that finding the right balance between cationic surfactant and plant oils may be the most appropriate path to develop effective nanoemulsions in hair treatment.

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Olive oil nanoemulsion preparation using high-pressure homogenization and d-phase emulsification – A design space approach

Cited by 41 publications

References 27 publications

Formulation and Preparation of Water-In-Oil-In-Water Emulsions Loaded with a Phenolic-Rich Inner Aqueous Phase by Application of High Energy Emulsification Methods

Formulation and Preparation of Water-In-Oil-In-Water Emulsions Loaded with a Phenolic-Rich Inner Aqueous Phase by Application of High Energy Emulsification Methods

Celastrol Nanoemulgel Formulation and in Vitro Penetration Test

Nanoemulsions containing plant oils: How do they influence hair treatment?

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