Olive Oil and Reduced Need for Antihypertensive Medications

Ferrara, L; Raimondi, Ambra; d'Episcopo, L; Guida, L.; Russo, Antonio Dello; Marotta, Teodoro

doi:10.1001/archinte.160.6.837

Cited by 257 publications

(144 citation statements)

References 33 publications

Supporting

Mentioning

133

Contrasting

Unclassified

Order By: Relevance

“…Therefore, our data suggest that the beneficial effect attributed to the MDP against CHD and other related diseases [5][6][7][8][9] could be due not only to diet, but also in part to a more active life-style during leisure time of those who follow the traditional Mediterranean diet [28].…”

Section: Discussionmentioning

confidence: 99%

“…The MDP could offer an interesting alternative in health promotion because this pattern has been postulated as being protective against coronary heart disease (CHD) [5,6]. The similarity of several risk factors and empirical and mechanistic evidence, support the hypothesis that some aspects of the MDP could also contribute to protect against the occurrence of diabetes mellitus type 2 [7], hypertension [8], stroke [9] and even against osteoporosis [10]. Some available evidence also suggests a beneficial effect in some types of cancer [11,12].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determinants of the adherence to an "a priori" defined Mediterranean dietary pattern

Sánchez-Villegas

Martínez²,

Irala

et al. 2002

European Journal of Nutrition

114

View full text Add to dashboard Cite

s Summary Background A prospective cohort study with university level participants was initiated to study the effect of Mediterranean diet on health. Aims The objective of this study was to identify possible lifestyle and socioeconomic variables associated with the consumption of a Mediterranean dietary pattern (MDP). Method: This analysis includes 1587 males and 2260 females. MDP was defined "a priori" by summing the standardized residuals of nutrients and foods after adjusting a regression model using total energy intake as the independent variable. Multiple regression and non-parametric locally weighted regression models were adjusted with the relative adherence to the MDP as the dependent variable in males and females. Results Women were more compliant than men with the MDP (Coefficient regression (b) = 4.1; Confidence Interval (CI) 95 % = 3.2 to 4.9). The compliance with the MDP was significantly poorer among younger participants both in men and women (p < 0.001 in men and in women). Participants who were more physically active were more likely to fulfill the traditional MDP (p = 0.01 in men and p < 0.001 in women). Conclusions Our findings provide evidence supporting the progressive departure from the traditional MDP in younger and highly educated subjects of the Mediterranean area. A more active life-style is associated with a better compliance with the MDP.s Key words eating patternsMediterranean dietary patternconfounders

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determinants of the adherence to an "a priori" defined Mediterranean dietary pattern

Sánchez-Villegas

Martínez²,

Irala

et al. 2002

European Journal of Nutrition

114

View full text Add to dashboard Cite

show abstract

“…Dietary trials (Appel et al, 1997;John et al, 2002) and observational studies (Psaltopoulou et al, 2004) have provided evidence to support the effectiveness of increasing the consumption of plant foods (especially vegetables and fruits) to decrease the risk of developing hypertension. Olive oil (Ferrara et al, 2000;Perona et al, 2004;Covas et al, 2006;Estruch et al, 2006) has been also suggested as an effective means to reduce blood pressure (BP) levels among hypertensives and to prevent the incidence of hypertension among normotensives (Alonso and Martinez-Gonzalez, 2004a;Perez-Jimenez et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Role of vegetables and fruits in Mediterranean diets to prevent hypertension

et al. 2008

View full text Add to dashboard Cite

Background/Objectives: Several studies support the effectiveness of increasing the consumption of fruits and vegetables (F&V) to prevent hypertension. However, none of them have been conducted in a Mediterranean setting. The aim of this study was to assess the association between F&V consumption and the risk of hypertension. Subjects/Methods: A prospective Mediterranean study (the SUN cohort), including 8594 participants aged 20-95 years (mean, 41.1) with median follow-up of 49 months. Results: Analyses according to the joint classification by olive oil and F&V consumption showed a significant inverse relation between F&V consumption and the risk of hypertension only among participants with a low olive oil consumption (o15 g per day). Also, tests for trend were significant only in the low olive oil intake stratum. Conclusions: We found a statistically significant interaction (P ¼ 0.01) between olive oil intake and F&V consumption. These data suggest a sub-additive effect of both food items.

show abstract

“…Also dietary interventions, regarding in particular the lipid component of the diet, were detected to induce an improvement in the endothelial function. O-3 fatty acids were able to improve endothelial function in patients with hypercholesterolemia (Goodfellow et al, 2000) and the monounsaturated virgin olive oil improved blood pressure (BP) control possibly by the activity of the antioxidant polyphenols (Ferrara et al, 2000). To our knowledge, no data are available in the literature regarding the effects of dietary protein intake on the endothelial function.…”

Section: Introductionmentioning

confidence: 99%

Effects of different dietary protein intakes on body composition and vascular reactivity

et al. 2005

View full text Add to dashboard Cite

Objective: To assess the effects of a diet rich in protein of animal origin in comparison to one with a protein intake of about 15% of the total daily calories on body composition and arterial function. Design: Randomized prospective study with parallel groups. Body weight (BW), blood pressure (BP), main parameters of carbohydrate and lipid metabolism, body mass composition by bioelectrical impedance analysis, forearm blood flow at rest and in the postischaemic phase by strain gauge plethysmography and flow-mediated dilation of the brachial artery by echography were measured at baseline and after 6 months of the dietary intervention. Subjects: In total, 15 clinically healthy male volunteers, regularly performing a mixed training three times weekly for 90 min. Intervention: The participants were randomly prescribed a diet with high (1.9 g/kg BW) or normal (1.3 g/kg BW) protein content. Statistical analysis: Differences between means were evaluated by the t-tests for paired or unpaired data and by one way analysis of variance. The strength of correlation between variables was investigated by bivariate Pearson correlation. Results: Serum cholesterol significantly decreased with both diets in comparison to baseline values, whereas BW was slightly but significantly reduced only by the high-protein (HP) diet. No change was detected in BP and the other metabolic parameters. Body mass composition was not significantly modified by either diet. On the other hand, postischaemic flow-mediated dilation of the brachial artery was enhanced by the sole normal protein (NP) diet, whereas no change in the forearm blood flow, both at rest and in the postischaemic phase, was detected. Conclusions: These preliminary results indicate that HP diet was found to be not useful in increasing the muscle mass in comparison to a NP intake. In contrast to this, the latter diet seems to enhance the endothelial function of the arterial vessels with a more pronounced dilatation of the lumen in response to the increase in blood flow.

show abstract

Olive Oil and Reduced Need for Antihypertensive Medications

Abstract: A slight reduction in saturated fat intake, along with the use of extra-virgin olive oil, markedly lowers daily antihypertensive dosage requirement, possibly through enhanced nitric oxide levels stimulated by polyphenols.

Cited by 257 publications

References 33 publications

Determinants of the adherence to an "a priori" defined Mediterranean dietary pattern

Determinants of the adherence to an "a priori" defined Mediterranean dietary pattern

Role of vegetables and fruits in Mediterranean diets to prevent hypertension

Effects of different dietary protein intakes on body composition and vascular reactivity

Contact Info

Product

Resources

About