Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial

Haidari, Fatemeh; Shayesteh, Forough; Mohammadshahi, Majid; Jalali, Mohammad Taha; Angali, Kambiz Ahmadi

doi:10.7762/cnr.2021.10.4.314

Cited by 3 publications

(3 citation statements)

References 58 publications

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“…Similarly, our OGTT and ITT results confirmed that oleuropein alleviated glucose intolerance and insulin resistance. Recent study of Haidari et al have demonstrated that the supplementation of olive leaves extract capsule comprised 50 mg oleuropein reduced insulin level in adults obese women and improve insulin sensitivity by increasing adiponectin secretion [ 32 ]. Additionally, Zhang et al, have revealed that the administration of oleuropein attenuate glucose level and enhanced insulin sensitivity in gestational diabetes mellitus (GDM) mice [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway

Hadrich

Mahmoudi

Chamkha

et al. 2023

Oxidative Medicine and Cellular Longevity

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Olive leaves extracts are known to exert potential pharmacological activities especially, antidiabetic and antiobesity. This study explores the anti-insulin resistant effect of olive leaves extracts and oleuropein in 3 T3-L1 cells and in high-fat diet fed rats. Our results showed that ethanol extract (EE) suppressed significantly ( P < 0.01 ) triacylglycerol accumulation. In preadipocytes cells, EE 1/100 decreased cell viability and induced apoptosis. Real-time PCR analysis showed that EE reduced the mRNA levels of adipogenesis (CEBP-α, PPARγ, SREBP-1c, and FAS) and proinflammatory (TNF-α and IL-6) genes. Moreover, the cotreatment of EE 1/1000 or oleuropein with insulin increased considerably the expression of p-IRS, p85-pI3K, and p-AKT. In vivo model, the oral administration of oleuropein at 50 mg/kg in rats fed with high fat diet for 8 weeks reduced inflammation in liver and adipose tissues (WAT), improved glucose intolerance, and decreased hyperinsulinemia. Furthermore, the immunohistochemistry revealed that the expression level of p-Akt, IRS1, and Glut-4 were significantly enhanced in liver and WAT tissues after oleuropein supplementation comparing with that in HFD group. Additionally, the expression of IRS1 was markedly ameliorated in pancreas. Our obtained results can be adopted as an approach to used olive leaves as complement to prevent insulin-resistance disease.

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Section: Discussionmentioning

confidence: 99%

Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway

Hadrich

Mahmoudi

Chamkha

et al. 2023

Oxidative Medicine and Cellular Longevity

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“…Specifically, several food ingredients affect PPARG expression and obesity-related parameters. Among them are anthocyanins [ 126 ], n-3 polyunsaturated fatty acids [ 127 , 128 , 129 ], olive leaf extract [ 130 ], geranylgeraniol (GGOH) [ 131 ], rice bran [ 132 ], and other compounds.…”

Section: Discussionmentioning

confidence: 99%

Adipocyte Biology from the Perspective of In Vivo Research: Review of Key Transcription Factors

Evseeva

Balashova

Kulebyakin

et al. 2021

IJMS

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Obesity and type 2 diabetes are both significant contributors to the contemporary pandemic of non-communicable diseases. Both disorders are interconnected and associated with the disruption of normal homeostasis in adipose tissue. Consequently, exploring adipose tissue differentiation and homeostasis is important for the treatment and prevention of metabolic disorders. The aim of this work is to review the consecutive steps in the postnatal development of adipocytes, with a special emphasis on in vivo studies. We gave particular attention to well-known transcription factors that had been thoroughly described in vitro, and showed that the in vivo research of adipogenic differentiation can lead to surprising findings.

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“…Oleuropein’s physiological impact has been investigated in several mammalian species including humans and mice, demonstrating a spectrum of benefits including antioxidant, antimicrobial, anticancer, hypoglycemic, hypolipidemic, anti-inflammatory, antiatherogenic, and antiviral effects ( Omar, 2010 ; Haidari et al, 2021 ). In addition, oleuropein has shown the potential to prevent hepatic steatosis in rodent models ( Park et al, 2011 ), a condition of particular concern in the poultry layer industry, where fatty liver disease affects laying hens ( Lin et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Oleuropein has hypophagic effects in broiler chicks

Sulaiman,

Vaughan,

Siegel

et al. 2024

Front. Physiol.

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Oleuropein, a phenolic compound derived from olives, has known glucoregulatory effects in mammalian models but effects in birds are unknown. We investigated effects of dietary supplementation and exogenous administration of oleuropein on broiler chick feed intake and glucose homeostasis during the first 7 days post-hatch. One hundred and forty-eight day-of-hatch broiler chicks were randomly allocated to one of four dietary treatments with varying oleuropein concentrations (0, 250, 500, or 1,000 mg/kg). Body weight and breast muscle and liver weights were recorded on day 7. In the next experiment, chicks received intraperitoneal (IP) injections of oleuropein at doses of 0 (vehicle), 50, 100, or 200 mg/kg on day 4 post-hatch, with feed intake and blood glucose levels measured thereafter. Lastly, chicks fed a control diet were fasted and administered intracerebroventricular (ICV) injections of oleuropein at doses of 0, 50, 100, or 200 μg, after which feed intake was recorded. Results indicated that IP and ICV injections led to decreased feed intake, primarily at 60 min post-injection, with effects diminishing by 90 min in the IP study. Blood glucose levels decreased 1-h post-IP injection at higher oleuropein doses. These findings suggest that oleuropein acts as a mild appetite suppressant and influences energy metabolism in broiler chickens.

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Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial

Cited by 3 publications

References 58 publications

Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway

Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway

Adipocyte Biology from the Perspective of In Vivo Research: Review of Key Transcription Factors

Oleuropein has hypophagic effects in broiler chicks

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