Olive and Turmeric Oils: Nutraceutical Effectiveness against Paracetamol-Induced Hepatotoxicity in Experimental Rats

Abstract

Olive and turmeric oils have numerous health benefits by preventing hepatotoxicity, moreover, each gives benefits that go beyond reducing risk factors of liver diseases. This investigation aimed to estimate the nutraceutical Effectiveness of olive and turmeric oils against paracetamol-induced hepatotoxicity in experimental rats. Twenty Sprague-Dawley male albino rats weighing 200±10 g each, were randomly divided into four groups; five rats each as follows; the first group was control negative (C -ve), the second group induced with liver intoxicated by paracetamol then fed on basal diet ( C +ve), the third group induced with liver intoxicated by paracetamol then fed on basal diet concurrently with orally administered of olive oil at a dose of 1 ml/kg body weight., and the fourth group induced with liver intoxicated by paracetamol then fed on basal diet concurrently with orally administered of turmeric oil at a dose of 1 ml/kg body weight. At the finale of investigational period 28 days, blood samples were collected for determination the following parameters; TC, TG, HDL, LDL VLDL, AI, glucose, TP and Alb. Moreover, BWG, FI and FER were calculated. The findings showed that all rats in the experimental groups orally injected with olive oil and turmeric oil at a dose 1 ml/kg body weight, each displayed a notable decline in TC, TG, LDL VLDL, AI, glucose, TP and Alb. Moreover, increasing in HDL, BWG, FI and FER. This study demonstrated that olive oil and turmeric oil had noticeable nutraceutical effectiveness against paracetamol-induced hepatotoxicity in experimental rats.