Olive and Its Phenolic Compound as the Promising Neuroprotective Agent

Kamil, Khidhir; Kumar, Jaya; Yazid, Muhammad Dain; Idrus, Ruszymah Bt Hj

doi:10.17576/jsm-2018-4711-24

Cited by 13 publications

(12 citation statements)

References 40 publications

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“…Besides, phenolic compounds with antioxidant properties such as oleuropein and epigallocatechin gallate (EGCG) are also of interest for early intervention in AD management (Kamil et al, 2018). This is mainly because a significant deficiency in brain antioxidant levels was identified as the oxidative stress marker in AD (Sharman et al, 2019).…”

Section: Emerging Treatments: Neuroinflammationmentioning

confidence: 99%

Pharmacotherapy of Alzheimer’s Disease: Seeking Clarity in a Time of Uncertainty

et al. 2020

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Alzheimer's disease (AD) is recognized as a major health hazard that mostly affects people older than 60 years. AD is one of the biggest medical, economic, and social concerns to patients and their caregivers. AD was ranked as the 5 th leading cause of global deaths in 2016 by the World Health Organization (WHO). Many drugs targeting the production, aggregation, and clearance of Ab plaques failed to give any conclusive clinical outcomes. This mainly stems from the fact that AD is not a disease attributed to a single-gene mutation. Two hallmarks of AD, Ab plaques and neurofibrillary tangles (NFTs), can simultaneously induce other AD etiologies where every pathway is a loop of consequential events. Therefore, the focus of recent AD research has shifted to exploring other etiologies, such as neuroinflammation and central hyperexcitability. Neuroinflammation results from the hyperactivation of microglia and astrocytes that release pro-inflammatory cytokines due to the neurological insults caused by Ab plaques and NFTs, eventually leading to synaptic dysfunction and neuronal death. This review will report the failures and side effects of many anti-Ab drugs. In addition, emerging treatments targeting neuroinflammation in AD, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and receptor-interacting serine/threonine protein kinase 1 (RIPK1), that restore calcium dyshomeostasis and microglia physiological function in clearing Ab plaques, respectively, will be deliberately discussed. Other novel pharmacotherapy strategies in treating AD, including disease-modifying agents (DMTs), repurposing of medications used to treat non-AD illnesses, and multi target-directed ligands (MTDLs) are also reviewed. These approaches open new doors to the development of AD therapy, especially combination therapy that can cater for several targets simultaneously, hence effectively slowing or stopping AD.

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Section: Emerging Treatments: Neuroinflammationmentioning

confidence: 99%

Pharmacotherapy of Alzheimer’s Disease: Seeking Clarity in a Time of Uncertainty

et al. 2020

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“…At present, the management of PDD is central upon synthetic drugs and natural products ( 59 ). However, this disease remains underdiagnosed owing to lack of reliable biomarkers and a disease specific-diagnostic criteria.…”

Section: Pns Demyelinating Diseasesmentioning

confidence: 99%

Peripheral Demyelinating Diseases: From Biology to Translational Medicine

et al. 2019

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Demyelinating diseases represent a spectrum of disorders that impose significant burden on global economy and society. Generally, the prognosis of these diseases is poor and there is no available cure. In recent decades, research has shed some light on the biology and physiology of Schwann cells and its neuroprotective effects in the peripheral nervous system (PNS). Insults to the PNS by various infectious agents, genetic predisposition and immune-related mechanisms jeopardize Schwann cell functions and cause demyelination. To date, there are no effective and reliable biomarkers for PNS-related diseases. Here, we aim to review the following: pathogenesis of various types of peripheral demyelinating diseases such as Guillain-Barre syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Anti-Myelin Associated Glycoprotein Neuropathy, POEMS syndrome, and Charcot-Marie-Tooth disease; emerging novel biomarkers for peripheral demyelinating diseases, and Schwann cell associated markers for demyelination.

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“…In epidemiological studies, the Mediterranean diet has been associated with reduced risk of developing cancer and cardiovascular and musculoskeletal diseases [ 5 , 6 , 7 , 8 ]. These health-beneficial effects are partially attributed to olive oil, which is used commonly in the Mediterranean diet [ 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review

2021

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Olive oil, which is commonly used in the Mediterranean diet, is known for its health benefits related to the reduction of the risks of cancer, coronary heart disease, hypertension, and neurodegenerative disease. These unique properties are attributed to the phytochemicals with potent antioxidant activities in olive oil. Olive leaf also harbours similar bioactive compounds. Several studies have reported the effects of olive phenolics, olive oil, and leaf extract in the modulation of thyroid activities. A systematic review of the literature was conducted to identify relevant studies on the effects of olive derivatives on thyroid function. A comprehensive search was conducted in October 2020 using the PubMed, Scopus, and Web of Science databases. Cellular, animal, and human studies reporting the effects of olive derivatives, including olive phenolics, olive oil, and leaf extracts on thyroid function were considered. The literature search found 445 articles on this topic, but only nine articles were included based on the inclusion and exclusion criteria. All included articles were animal studies involving the administration of olive oil, olive leaf extract, or olive pomace residues orally. These olive derivatives were consistently demonstrated to have thyroid-stimulating activities in euthyroid or hypothyroid animals, but their mechanisms of action are unknown. Despite the positive results, validation of the beneficial health effects of olive derivatives in the human population is lacking. In conclusion, olive derivatives, especially olive oil and leaf extract, could stimulate thyroid function. Olive pomace residue is not suitable for pharmaceutical or health supplementation purposes. Therapeutic applications of olive oil and leaf extract, especially in individuals with hypothyroidism, require further validation through human studies.

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Olive and Its Phenolic Compound as the Promising Neuroprotective Agent

Cited by 13 publications

References 40 publications

Pharmacotherapy of Alzheimer’s Disease: Seeking Clarity in a Time of Uncertainty

Pharmacotherapy of Alzheimer’s Disease: Seeking Clarity in a Time of Uncertainty

Peripheral Demyelinating Diseases: From Biology to Translational Medicine

Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review

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