Oligosaccharides containing fucose linked α(1–3) and α(1–4) to N-acetylglucosamine cause decompaction of mouse morulae

Bird, Jeremy; Kimber, Susan J.

doi:10.1016/0012-1606(84)90101-5

Cited by 195 publications

(80 citation statements)

References 51 publications

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“…To exclude the possibility that Fut10 overexpression increases Fut9 activity, we utilized neurospheres derived from the GE of E15.5 Fut9 Ϫ/Ϫ embryos. The difference between the number of secondary neurospheres obtained from Fut9 Ϫ/Ϫ primary neurospheres infected with either control retroviruses or Fut10-expressing retroviruses was similar to the difference between the number obtained from Fut9 ϩ/Ϫ primary neurospheres infected with either control retroviruses or Fut10-expressing retroviruses (F (2,6) …”

Section: Fut10 Is Required For the Maintenance Of Es Cells And Neuralsupporting

confidence: 57%

The Lewis X-related α1,3-Fucosyltransferase, Fut10, Is Required for the Maintenance of Stem Cell Populations

Kumar

Torii

Ishino

et al. 2013

Journal of Biological Chemistry

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Background:The Lewis X carbohydrate antigen is abundantly expressed in several stem cell populations. Results: Fut10 is responsible for the synthesis of unique types of Lewis X on N-glycans and alters stem cell functions. Conclusion: Fut10 are required for the maintenance of stem cells and neural development. Significance: Learning Fut10 function is crucial for understanding how stemness is maintained.

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Section: Fut10 Is Required For the Maintenance Of Es Cells And Neuralsupporting

confidence: 57%

The Lewis X-related α1,3-Fucosyltransferase, Fut10, Is Required for the Maintenance of Stem Cell Populations

Kumar

Torii

Ishino

et al. 2013

Journal of Biological Chemistry

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“…This antigen first appears on the surface of cells at the eight-cell stage of mouse embryogenesis and later becomes restricted to specific cell types during murine development (Solter and Knowles 1978;Pennington et al 1985). Complementary experimental observations by two groups suggest that the SSEA-1 antigen may participate in adhesive events leading up to and involving compaction (Bird and Kimber 1984;Fenderson et al 1984). Although the molecular nature of these processes is undefined, recent biochemical evidence suggests that homotypic carbohydrate-carbohydrate interactions between SSEA-1 molecules may be operative in this context (Eggens et al 1989).…”

mentioning

confidence: 98%

“…These patterns are discernible first on the surfaces of preimplantation and early postimplantation embryomc cell aggregates (Bird and Kimber 1984;Fenderson et al 1984;Pennington et al 1985;Fenderson et al 1986;Kimber 1986). In the mature organism, expression of distinct oligosaccharide moieties ultimately becomes restricted to specific cell types (Szulman 1960(Szulman , 1962Watkins 1980;Dodd and Jessel 1985).…”

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confidence: 99%

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A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.

Kukowska-Latallo¹,

Larsen²,

Nair³

et al. 1990

Genes Dev.

491

274

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The stage-specific embryonic antigen SSEA-I is a cell-surface oligosaccharide molecule expressed with temporal precision during the murine preimplantation period and implicated in adhesive events involving the process of compaction. We used a mammalian transient expression system to isolate a cloned human cDNA that determines expression of the SSEA-I molecule. The cDNA sequence predicts a type II transmembrane protein with a domain structure similar to mammalian glycosyltransferases, but without primary sequence similarity to these enzymes. The carboxy-terminal domain of this protein was shown to be catalytically active as a fucosyltransferase when expressed in COS-I cells as a portion of a secreted protein A fusion peptide. The enzyme is an exceptional glycosyltransferase in that it can use both type I and type II oligosaccharides as acceptor substrates to generate subterminal Fucc~(l,4)-and Fuc~(l,3)-linkages, respectively, in a manner analogous to the human Lewis blood group fucosyltransferase. Southern blot analysis shows that the cDNA corresponds to sequences syntenic to the Lewis locus on chromosome 19. These results indicate that this cDNA is the product of the human Lewis blood group locus, provide genetic confirmation of the hypothesis that this enzyme can catalyze two distinct transglycosylation reactions, and outline an approach to the isolation of other sequences that determine expression of developmentally regulated oligosaccharide antigens.

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“…The three main groups are the so called globo-, lacto-, and ganglio-series glycolipids (Svennerholm, 1964). Among others, glycolipids are involved in early embryonic development and in mediation/modification of growth factor action (Bird and Kimber, 1984;Bremer et al, 1984;Fenderson et al, 1984;Cuello et al, 1989;Eggens et al, 1989). Therefore, glycolipids might be important in the development of TGCTs.…”

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confidence: 99%

Glycolipids of human primary testicular germ cell tumours

Olie

Fenderson²,

Daley³

et al. 1996

Br J Cancer

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Summary The glycolipid content of human non-seminomatous germ cell tumour cell lines correlates with their differentiation lineage. To analyse whether this reflects the situation in primary tumours, we studied five embryonal carcinomas, five yolk sac tumours and nine (mixed) non-seminomas, using thin-layer chromatography and carbohydrate immunostaining. We also analysed the glycolipid content of 19 seminomas to reveal their relationship with non-seminomas. Lactosylceramide (CDH) was detected in all embryonal carcinomas, but in fewer than half of the seminomas. Seminomas and embryonal carcinomas contained globoseries glycolipids, including globotriosylceramide (Gb3), globoside (Gb4), galactosyl globoside (Gb5) and sialyl galactosyl globoside (GL7). The lacto-series glycolipid Lex was found in all embryonal carcinomas, but only in one seminoma. Gangliosides GD3 and GT3 were detected in many seminomas, but rarely in embryonal carcinomas. Yolk sac tumours displayed a heterogeneous glycolipid profile. Compared with seminomas and pure embryonal carcinomas, differentiated non-seminomas had reduced levels of globo-series glycolipids, especially Gb3 and Gb5, whereas CDH, Lex, GD3 and GT3 were found in the majority of cases. Thus, the glycolipid content of non-seminoma cell lines reflects the situation in primary tumours. Globo-series glycolipids are similarly expressed in seminomas and embryonal carcinomas. The expression of Gb3 and Gb5 is reduced in non-seminomas upon differentiation. Lex expression in non-seminomas, including embryonal carcinomas, allows discrimination from seminomas. Expression of gangliosides in seminomas might indicate their maturation from ganglioside-negative precursor cells. Reprogramming of these precursors would result in the formation of Lex-expressing embryonal carcinomas.

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Oligosaccharides containing fucose linked α(1–3) and α(1–4) to N-acetylglucosamine cause decompaction of mouse morulae

Cited by 195 publications

References 51 publications

The Lewis X-related α1,3-Fucosyltransferase, Fut10, Is Required for the Maintenance of Stem Cell Populations

The Lewis X-related α1,3-Fucosyltransferase, Fut10, Is Required for the Maintenance of Stem Cell Populations

A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.

Glycolipids of human primary testicular germ cell tumours

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