Oligonucleotide-stabilized Ag nanoclusters as novel fluorescence probes for the highly selective and sensitive detection of the Hg2+ ion

Guo, Weiwei; Yuan, Jinghe; Wang, Erkang

doi:10.1039/b821518a

Cited by 326 publications

(204 citation statements)

References 26 publications

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“…These DNA-templated Ag nanoclusters show strong fluorescence with high quantum yields and have been successfully applied as fluorophores in single molecule microscopy, biolabeling, and single molecule optoelectronics. [21,[26][27][28][29][30][31] Other non-DNA templated Ag nanoclusters have also been synthesized recently by chemical reduction. A multistage ''cyclic reduction under oxidative conditions'' (CROC) approach has been applied to prepare Ag nanoclusters with water-soluble chiral thiols (e.g., captopril ((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-pyrrolidine-2-carboxylic acid), glutathione (GSH ¼ g-Glu-Cys-Gly), and cysteine) as strong protecting and stabilizing ligands.…”

Section: Chemical Reduction Preparation Of Ag Nanoclustersmentioning

confidence: 99%

Water‐Soluble Fluorescent Silver Nanoclusters

2010

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Ag nanoclusters consist of several to roughly a hundred atoms and possess sizes comparable to the Fermi wavelength of electrons; they exhibit molecule-like properties, including discrete electronic transitions and strong fluorescence. These nanoclusters are of significant interest because they provide the bridge between atomic and nanoparticle behavior in noble metals. Since the first observations of photoluminescence from Ag nanoclusters, substantial effort has been made to prepare Ag nanoclusters and explore their potential applications. The synthesis of well-defined Ag nanoclusters, however, is difficult due to aggregation of nanoclusters, especially in aqueous solutions. In this Research News article, we highlight some recent progress on solution-based synthesis of water-soluble Ag nanoclusters using radiolytic, chemical reduction and photochemical approaches to prepare fluorescent Ag nanoclusters.

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Section: Chemical Reduction Preparation Of Ag Nanoclustersmentioning

confidence: 99%

Water‐Soluble Fluorescent Silver Nanoclusters

2010

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“…In this case, quenching was likely related to AuNC aggregation since these metal ions could be chelated by the surface carboxyl ligands. In another sensing system, Wang and co-workers showed the lack of fluorescence lifetime change by Hg 2+ induced AgNC quenching, suggesting disruption of the ground state of AgNCs [123].…”

Section: Reactive Quenchersmentioning

confidence: 99%

DNA-stabilized, fluorescent, metal nanoclusters for biosensor development

Liu

2014

TrAC Trends in Analytical Chemistry

195

141

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In the past decade, fluorescent silver, gold and copper nanoclusters (Ag, Au and CuNCs) have emerged as a new class of signaling moiety for biosensor development. Compared to semiconductor quantum dots, metal NCs have less toxicity concerns and can be more easily conjugated to biopolymers. Due to their extremely small size, these NCs need a stabilizing ligand. Many polymers, proteins and nucleic acids have been reported to stabilize NCs. In particular, many DNA sequences produce highly fluorescence NCs. Coupling these DNA stabilizers with other sequences such as aptamers has generated a large number of biosensors. In this review, the synthesis of DNA and nucleotide-templated NCs is first summarized; their chemical interactions are also discussed. In the second part, the properties of NCs such as fluorescence quantum yield, emission wavelength and lifetime, structure and photostability are briefly reviewed. In the last part, various sensor design strategies using these NCs are categorized into the following four classes: 1) fluorescence de-quenching; 2) generation of templating DNA sequences to produce NCs; 3) change of nearby environment; and 4) reacting with heavy metal ions or other quenchers. Finally, the future trends in this field are discussed.

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“…Among various methods, template-based synthesis techniques are the most recognized ones. Different kinds of templates such as polymers, 19,24,25 proteins, 26,27 DNA, 21,28 oligonucleotides, 29,30 polyelectrolytes, 31 dendrimers, 32,33 and polymer microgels 34 have been used so far. Small molecules, especially those containing carboxylic or thiol groups, 35,36 were also utilized as stabilizers.…”

Section: Introductionmentioning

confidence: 99%

A facile synthesis of highly stable and luminescent Ag clusters: a steady-state and time-resolved spectroscopy study

Pal

Kryschi

2015

Phys. Chem. Chem. Phys.

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In this paper, we reported a very simple and environmentally friendly procedure for the synthesis of bright luminescent and nearly monodisperse Ag nanoclusters stabilized by a poly(N-vinylpyrrolidone) homopolymer.In this synthesis route acetonitrile or N,N-dimethylformamide (DMF) acts as both solvent and a reducing agent at their respective reflux temperatures. The as-prepared Ag clusters were found to be highly stable in various solvents as well as show nearly no changes in their emission intensity in solutions with different pH values and ionic strengths. Remarkably, the acetonitrile method predominantly produces blue emitting Ag clusters with a photoluminescence (PL) emission maximum at 424 nm (quantum yield 3.5%), whereas mainly blue-green emitting Ag clusters with the PL emission maximum at 450 nm (quantum yield 2.7%) were formed using the DMF method. The photo-physical, electronic, structural and morphological properties of the Ag clusters were investigated by performing UV/Vis absorption spectroscopy, stationary and time-resolved PL spectroscopy, X-ray photoelectron spectroscopy, femtosecond transient absorption spectroscopy, and transmission electron microscopy experiments.

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Oligonucleotide-stabilized Ag nanoclusters as novel fluorescence probes for the highly selective and sensitive detection of the Hg2+ ion

Abstract: Fluorescent oligonucleotide-stabilized Ag nanoclusters are demonstrated as novel and environmentally-friendly fluorescence probes for the determination of Hg(2+) ions with a low detection limit and high selectivity.

Cited by 326 publications

References 26 publications

Water‐Soluble Fluorescent Silver Nanoclusters

Water‐Soluble Fluorescent Silver Nanoclusters

DNA-stabilized, fluorescent, metal nanoclusters for biosensor development

A facile synthesis of highly stable and luminescent Ag clusters: a steady-state and time-resolved spectroscopy study

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