Oligomannose-Coated Liposome as a Novel Adjuvant for the Induction of Cellular Immune Responses to Control Disease Status

Abstract

Professional phagocytic cells, such as dendritic cells, are mainly responsible for phagocytosis, antigen presentation, and cytokine secretion, which induce subsequent activation of T cell-mediated immunity. Thus, strategies that deliver antigens and stimulatory signals to the cells have significant implications for vaccine design. In this paper, we summarize the potential for liposomes coated with the neoglycolipids containing oligomannose residues (OMLs) as a novel adjuvant for induction of Th1 immune responses and CTLs specific for the encased antigen. OMLs preferentially take up peripheral phagocytic cells. In response to OML uptake, the cells secrete IL-12 selectively, enhance the expression of costimulatory molecules, and migrate into lymphoid tissues from peripheral tissues. OMLs also have the ability to deliver encapsulated protein antigens to the MHC class I and class II pathways to generate antigen-specific CTLs and Th1 cells, respectively, and lipid antigen to CD1d to activate NKT cells. Since administration of OML-based vaccines can eliminate an established tumor, inhibit elevation of the serum IgE level, and prevent progression of protozoan infections in several murine, human, and bovine models, OML-based vaccines have revealed their potential for clinical use in vaccination for a variety of diseases in which CTLs and/or Th1 cells act as effector cells.

N-Glycosylation of Cholera Toxin B Subunit: Serendipity for Novel Plant-Made Vaccines?

“…Given this, a number of studies have attempted to exploit C-type lectin receptors to efficiently deliver and present antigens to T cells (Apostolopoulos et al, 2013 ; Lepenies et al, 2013 ; van Kooyk et al, 2013 ; Sedaghat et al, 2014 ). For instance, oligomannose-coated liposome was shown to be capable of delivering encapsulated protein antigens to the MHC class I and class II pathways in antigen presenting cells and thereby generating antigen-specific cytotoxic T cells and type 1 helper T cells (Kojima et al, 2013 ). These findings provide an implication for the potential use of N -glycosylated CTB.…”

Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with <i>Neospora caninum</i>

“…In one of our studies, we focused on developing a next-generation vaccine based on liposomes coated with neoglycolipids that contain oligomannose residues (OMLs) as a novel adjuvant for the induction of Th1 immune responses and cytotoxic T lymphocytes (CTLs) specific for the encased antigen [ 9 ]. The liposomes were coated with a neoglycolipid consisting of mannotriose and dipalmitoylphosphatidylethanolamine (otherwise called Man3-DPPE) [ 20 ] ( Fig. 3

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Next generation immunotherapy for tree pollen allergies

“…Thus, OMLs preferentially induce Th1 immune response against the capsulated antigens. 49 Ishii et al entrapped purified Cry j 1 protein with OMLs and showed that two injections of such Cry j 1/OMLs induced robust Th1 cytokine response and IgG2a (a Th1 type antibody) production in mice. Total IgE levels were suppressed in Cry j 1/ OMLs treated mice after Cry j 1/Alum challenge in both prophylactic and therapeutic models.…”