Oligodendrogliomas: Clinicopathological correlations

Kros, Johan M.

doi:10.1007/bf01052654

Cited by 7 publications

(2 citation statements)

References 25 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study showed that younger age (≤36 years) and female sex had non-significant improvements in outcome. One study showed improved outcomes in young (age < 40 years) [8], while the other did not [9]. The female sex has a better outcome, possibly because of a tumor suppressor gene in the additional X chromosome [10].…”

Section: Discussionmentioning

confidence: 98%

The Outcome of Anaplastic Glioma Treated at a Tertiary Cancer Care Institute in South Asia

Natarajan,

Radhakrishnan,

John

2024

Asian Pac J Cancer Care

View full text Add to dashboard Cite

Objective: Anaplastic glioma is a highly aggressive brain tumor that often occurs in young adults. There is a lack of data from India on anaplastic gliomas. This study aims to evaluate the prognostic factors of anaplastic glioma and correlate them with the outcome. Materials and Methods: This is a retrospective observational study of 57 patients with anaplastic glioma treated from 1996 to 2015 in a cancer institute in Chennai. We captured data from the cancer institute’s hospital-based electronic health record tumor registry and correlated factors including age, sex, histology, site of disease, type of surgery, adjuvant treatment, and radiation treatment technique with outcome. For the calculation of progression-free survival (PFS) and Overall Survival (OS), we used Statistical Package for Social Science (SPSS) software. Result: This analysis included fifty-seven patients, with a median follow-up of 34 months. The median progression-free survival (PFS) and overall survival (OS) were 28 and 41 months, respectively. On univariate analysis, factors associated with improved survival include Anaplastic Oligodendroglioma histology (HR-0.43, CI-0.22-0.80, P=0.006), Frontal lobe location (HR-1.96, CI-1.07-3.58, P=0.025) Gross total resection (HR-1.94, CI-1.03-3.64, P=0.034), and addition of Temozolamide (HR-2.09, CI-1.14-3.84, P=0.014). On multivariate analysis Anaplastic Oligodendroglioma histology, (HR-0.49,CI-0.25-0.95,P=0.037), Frontal lobe (HR-2.14,CI-1.12-4.07,P=0.021), Gross total resection (HR-2.89,CI-1.47-5.69,P=0.002) and addition of Temozolamide (HR-2.02,CI-1.07-3.81,P=0.029) remained significant factors for improved OS. Conclusion: Among the various clinical and treatment-related prognostic factors, our study revealed that anaplastic oligodendroglioma histology, frontal lobe location, gross total resection, and addition of temozolomide chemotherapy to radiation showed improved outcomes.

show abstract

Section: Discussionmentioning

confidence: 98%

The Outcome of Anaplastic Glioma Treated at a Tertiary Cancer Care Institute in South Asia

Natarajan,

Radhakrishnan,

John

2024

Asian Pac J Cancer Care

View full text Add to dashboard Cite

show abstract

“…[21] The 5-year survival rate ranges from 34 to 66% and the 10-year survival rate from 24 to 34% in patients undergoing surgical resection with or without adjuvant therapy. [4,13,21,22,30] Many factors, including histological grade, degree of surgical resection, neurological status, and ABO blood group have been shown to correlate with prognosis. [4,21,22,30] Additional treatment with postoperative radiation therapy has yielded equivocal results: one study has shown that radiation therapy correlated with a favorable outcome; [4] however, three series have shown that adjuvant radiation therapy had no significant impact on survival compared to patients treated with surgery alone.…”

Section: Therapy and Outcomementioning

confidence: 99%

Dysembryoplastic neuroepithelial tumor and oligodendroglioma: the diagnostic value of magnetic resonance spectroscopy

Sherburn¹,

Bahn²,

Gökden³

et al. 1998

FOC

View full text Add to dashboard Cite

Preoperative differentiation between dysembryoplastic neuroepithelial tumor (DNT) and low-grade glioma is often not possible. Dysembryoplastic neuroepithelial tumor is a recently described entity of uncertain origin; however, the diagnosis has important clinical implications. Clinical and radiological findings of DNT and low-grade glioma, especially oligodendroglioma, may be similar. Treatment options and prognosis differ significantly between these two lesions; consequently, accurate diagnosis is imperative. The authors describe two individuals who presented simultaneously at their institution: one patient with an oligodendroglioma and a second patient with DNT. The natural history, neurodiagnostic, and pathological features of each are reviewed with special emphasis on the potential utility of magnetic resonance spectroscopy in differentiating these lesions.

show abstract