Oligodendroglioma with Remote Metastases

Spataro, Joseph; Sacks, Oliver

doi:10.3171/jns.1968.28.4.0373

Cited by 33 publications

(9 citation statements)

References 15 publications

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“…Recently, the number of reports substantially increased, a trend suspected to be related to more aggressive chemotherapy directly leading to longer survival times (129). The skeletal system, lymph nodes, lung and pleura, and liver are the most commonly reported extraneural sites (14,128,130,131). Local recurrence and spread of anaplastic oligodendroglioma is more commonly noted in patients who have undergone multiple craniotomies, whereas distant metastasis is more commonly seen in patients who have received early radiation therapy and chemotherapy (128).…”

Section: Recurrence and Metastasismentioning

confidence: 98%

Oligodendroglioma and Its Variants: Radiologic-Pathologic Correlation

Koeller¹,

Rushing²

2005

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121

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Oligodendroglioma is the third most common glial neoplasm and most commonly arises in the frontal lobe. It occurs in males more frequently, and the peak manifestation is during the 5th and 6th decades. Children are affected much less commonly. The clinical presentation is often of several years duration with most patients presenting with seizures, reflecting the strong predilection of this tumor to involve the cortical gray matter. Current histopathologic classification schemes recognize two main types of tumors: well-differentiated oligodendroglioma and its anaplastic variant. Less commonly, neoplastic mixtures of both oligodendroglial and astrocytic components occur and are termed oligoastrocytomas, with both well-differentiated and anaplastic forms. Surgical resection is the mainstay of initial treatment, and many patients experience a long progression-free period. Recent genotyping has revealed chromosomal loss of 1p and 19q as a genetic signature in most oligodendrogliomas, and these tumors respond favorably to chemotherapy. Hence, radiation therapy is now generally reserved for partially resected tumors and cases that failed to benefit from chemotherapy. At cross-sectional imaging, the tumor characteristically involves the cortical gray matter and frequently contains calcification. Robust enhancement is not a common feature and suggests transformation to a higher histologic grade. Advanced magnetic resonance imaging techniques and metabolic imaging play increasingly important roles in both pre- and postoperative assessment of these complex neoplasms.

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Section: Recurrence and Metastasismentioning

confidence: 98%

Oligodendroglioma and Its Variants: Radiologic-Pathologic Correlation

Koeller¹,

Rushing²

2005

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121

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“…In 1968, a second case was reported in a 7-year-old girl with recurrent oligodendroglioma of the left fronto-parietal and occipital brain, who developed subcutaneous scalp involvement after craniotomy and surgical resection. 5 This patient progressed to widely metastatic disease. Three additional cases of scalp involvement by oligodendroglioma have been reported in a 33-year-old, 6 a 12-year-old, 7 and a 32-year-old patients.…”

Section: Discussionmentioning

confidence: 97%

“…1,8,18 Reported sites of metastasis include uninvolved brain, spinal cord, dura, regional and distant lymph nodes, parotid gland, thymus, neck, chest wall, lung, pleura, iliopsoas muscle, liver, spleen, pancreas, and bone (ie, vertebrae, ribs, sternum, humerus, and femur). [4][5][6][7] On the other hand, other primary brain tumors that have been reported to involve the skin of the scalp, whether from surgical implantation, direct extracranial extension, or metastasis, include astrocytoma (particularly anaplastic astrocytoma), anaplastic ependymoma, glioblastoma multiforme, and meningioma. 19,[46][47][48][49][50][51][52][53][54][55][56] Cerebrospinal fluid may serve as a means for AO to metastasize to other sites in the central nervous system, and direct tumor extension along the leptomeninges can give rise to leptomeningeal oligodendrogliomatosis.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Oligodendroglioma Involving the Subcutaneous Tissue of the Scalp

McLemore

Bruner

Curry

et al. 2012

The American Journal of Dermatopathology

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Anaplastic oligodendroglioma [AO, World Health Organization (WHO) grade III] is an uncommon but aggressive tumor of the central nervous system that typically arises in adults. Clinically, patients present with seizures, and the prognosis is considered poor. Metastatic spread is extremely rare. We report an exceptional case of AO with extracranial scalp involvement, which arose in a patient with recurrent primary AO of the brain after chemoradiation, multiple cranial surgical resections, and subsequent scalp reconstruction. On histopathology, the subcutaneous tissue of the scalp contained several clusters and infiltrating cords of relatively small, epithelioid cells with hyperchromatic nuclei, scant eosinophilic cytoplasm, and perinuclear halos, which gave the cells a characteristic fried-egg appearance. By immunohistochemistry, the lesional cells were positive for glial fibrillary acidic protein and S-100. It is likely that surgical implantation and direct extracranial extension after craniotomy were the mechanisms responsible for dissemination of the patient's tumor.

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“…Remote metastases of glial tumours are in general rather rare and only few instances of extraneural metastases of oligodendroglioma have been found in the literature (James and Pagel, 1951;Spataro and Sacks, 1968). We are reporting a case of an operated oligodendroglioma, in which metastases to the lumbar vertebrae were found at necropsy.…”

mentioning

confidence: 91%

“…

Remote metastases of glial tumours are in general rather rare and only few instances of extraneural metastases of oligodendroglioma have been found in the literature (James and Pagel, 1951;Spataro and Sacks, 1968). We are reporting a case of an operated oligodendroglioma, in which metastases to the lumbar vertebrae were found at necropsy.

CASE REPORT

A 58-year-old woman (NI 249-67) had first experienced the sudden onset of severe headache, vomiting, and right-sided hemiparesis about 3j years before death.

These symptoms subsided within a few hours and recurred several months later intermittently, at this time associated with disturbances of speech.

…”

mentioning

confidence: 99%