Oligodendroglioma with neurocytic differentiation and characteristic loss of heterozygosity on chromosomes 1p and 19q

Vajtai, István; Arnold, Marlène; Vassella, Erik

doi:10.1007/s00401-005-1091-8

Cited by 13 publications

(10 citation statements)

References 8 publications

(8 reference statements)

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“…Therefore, our interpretation was that these were essentially oligodendrogliomas with ganglioglioma-like maturation. We believe that this represents an unusual form of neuronal and to a lesser degree, astrocytic differentiation, somewhat analogous to prior studies showing foci of neurocytic differentiation in oligodendrogliomas [20, 22, 28, 36]. This potential link between these two forms of neuronal maturation was further strengthened by the finding of both neurocytic and gangliocytic maturation in one of our tumors (case 6).…”

Section: Discussionsupporting

confidence: 89%

“…In most of these cases, the neuronal phenotype is not evident by routine histology alone. Nonetheless, we and others have reported rare examples with overt neurocytic differentiation, associated with slightly smaller darker nuclei, as well as neuropil and rosette formation [20, 22, 28, 36]. When this neurocytic differentiation is extensive, the distinction from extraventricular neurocytoma can be extremely difficult.…”

Section: Introductionmentioning

confidence: 87%

“…Since the initial discovery that this tumor type is associated with a useful genetic signature predicting favorable prognosis and enhanced therapeutic sensitivity [1, 9, 14, 31, 33], there has been renewed interest in fully characterizing the morphologic and biologic spectra of oligodendroglial neoplasms. One surprising finding from this pursuit has been that despite considering oligodendroglioma a purely glial neoplasm, they can show neuronal features at multiple levels, including immunohistochemically, ultrastructurally, in vitro, and on expression profiling studies [11, 13, 20, 22–25, 27, 28, 36, 38–40]. In most of these cases, the neuronal phenotype is not evident by routine histology alone.…”

Section: Introductionmentioning

confidence: 99%

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Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall

et al. 2010

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Although oligodendroglial neoplasms are traditionally considered purely glial, increasing evidence suggests that they are capable of neuronal or neurocytic differentiation. Nevertheless, ganglioglioma-like foci (GGLF) have not been previously described. Herein, we report seven examples where the primary differential diagnosis was a ganglioglioma with an oligodendroglial component. These five male and two female patients ranged in age from 29 to 63 (median 44) years at initial presentation and neuroimaging features were those of diffuse gliomas in general. At presentation, the glial component was oligodendroglioma in six and oligoastrocytoma in one; one was low-grade and six were anaplastic. A sharp demarcation from adjacent GGLF was common, although some intermingling was always present. The GGLF included enlarged dysmorphic and occasionally binucleate ganglion cells, Nissl substance, expression of neuronal antigens, GFAP-positive astrocytic elements, and low Ki-67 labeling indices. In contrast to classic ganglioglioma, however, cases lacked eosinophilic granular bodies and CD34-positive tumor cells. Scattered bizarre astrocytes were also common and one case had focal neurocytic differentiation. By FISH analysis, five cases showed 1p/19q codeletion. In the four cases with deletions and ample dysmorphic ganglion cells for analysis, the deletions were found in both components. At last follow-up, two patients suffered recurrences, one developed radiation necrosis mimicking recurrence, and one died of disease 7.5 years after initial surgery. We conclude that GGLF represents yet another form of neuronal differentiation in oligodendroglial neoplasms. Recognition of this pattern will prevent a misdiagnosis of ganglioglioma with its potential for under-treatment.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall

et al. 2010

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“…However, this issue is complicated by recent evidence that phenotypic boundaries in the above setting may indeed not be always clear‐cut. In fact, immunostaining for synaptophysin had been instrumental in the historical emancipation of neurocytoma from oligodendroglioma; however, subsequent studies have established neurocytic differentiation in genotypically unambiguous oligodendrogliomas . To make this theme of overlapping phenotypes come full circle, mention must be made of a rare instance of ependymal differentiation within a neurocytoma, located in the cerebellum …”

Section: Discussionmentioning

confidence: 99%

“…In fact, immunostaining for synaptophysin had been instrumental in the historical emancipation of neurocytoma from oligodendroglioma; however, subsequent studies have established neurocytic differentiation in genotypically unambiguous oligodendrogliomas. 34 To make this theme of overlapping phenotypes come full circle, mention must be made of a rare instance of ependymal differentiation within a neurocytoma, located in the cerebellum. 35 The caveat mentioned above may apply to most of the cases in the literature reported as infratentorial oligodendrogliomas.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic oligodendroglioma arising from the brain stem and featuring 1p/19q co‐deletion

et al. 2013

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With respect to localization, oligodendrogliomas are characterized by a marked preponderance of the cerebral hemispheres. Outside these typical sites, any tumor histopathologically reminiscent of oligodendroglioma a priori is likely to represent one of its morphological mimics, including clear cell ependymoma, neurocytoma, pilocytic astrocytoma or glioneuronal tumors. This is particularly relevant as several of the latter are in principle curable by surgery. Among extrahemispherical sites, bona fide oligodendroglioma - as characterized by loss of heterozygosity (LOH) of chromosome arms 1p and 19q - so far has not been documented to occur in the brain stem. Here, we report the case of a 55-year-old female patient with an anaplastic oligodendroglioma (WHO grade III) of the brain stem and cerebellum diagnosed by stereotactic biopsy and featuring combined LOH of 1p and 19q. A morphological peculiarity was a population of interspersed tumor giant cells, a phenomenon that has been referred to as polymorphous oligodendroglioma. Our findings confirm the notion that - although very infrequently - true oligodendrogliomas do occur in the infratentorial compartment.

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Atypical Histologic Features and Patterns of Malignant Evolution in Tanycytic Ependymoma

Vajtai

Hewer

2012

Tumors of the Central Nervous System, Volume 8

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Oligodendroglioma with neurocytic differentiation and characteristic loss of heterozygosity on chromosomes 1p and 19q

Cited by 13 publications

References 8 publications

Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall

Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall

Anaplastic oligodendroglioma arising from the brain stem and featuring 1p/19q co‐deletion

Atypical Histologic Features and Patterns of Malignant Evolution in Tanycytic Ependymoma

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