Oligodendroglioma and cerebral cavernous angioma

Chee, Chee Pin; Johnston, R. Scott; Doyle, D; Macpherson, P.

doi:10.3171/jns.1985.62.1.0145

Cited by 31 publications

(13 citation statements)

References 7 publications

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“…We only reported 1 case of a 17-year-old boy with the familial form of CMs and a previous diagnosis of Klinefelter’s syndrome. The coexistence of CMs with several types of intracranial tumors has also been reported in the literature [142,143,144,145], but, in our opinion, these conditions remain occasional occurrences and, for the most part, are not typical of the pediatric age group.…”

Section: Resultsmentioning

confidence: 86%

Cavernous Malformations of the Central Nervous System in the Pediatric Age Group

et al. 2009

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Objective: The main clinico-diagnostic features, risk factors and associated diseases of cavernous malformations (CMs), also called cavernous angiomas or cavernomas, of the central nervous system (CNS) in children are described, and the most relevant differences compared to the affected adult population are pointed out, focusing on the management of pediatric patients harboring cranial and spinal CMs. Materials: This was a retrospective study of a series of 42 children symptomatic for CMs of the cranial and spinal compartments (35 supratentorial brain lesions, 5 infratentorial and 2 in the spinal region) operated on between 1975 and 2005, with a clinical follow-up ranging from 12 to 192 months. The results were compared with those found in the most recent literature dealing with pediatric CMs of the CNS. Results: Surgical treatment produced excellent or good results in 69% of our 42 children. Unchanged neurological deficits were observed in 23.8% of cases, while morbidity from surgical procedures was 7.14%. Mortality was absent in this series. These surgical results are comparable with those found in the literature, where morbidity and mortality rates from surgery are 8.8 and 1.13%, respectively, and are mostly associated with procedures for the excision of deep, critically located cavernomas. Conclusion: CMs represent the most common CNS vascular lesion in children, although their incidence is 4 times lower than that of the adult population. The natural history of pediatric CMs throughout the neuraxis seems to be more aggressive than in adult patients; these lesions have higher rates of growth and hemorrhage, larger dimensions and often atypical radiological pictures at diagnosis. Beside the familial form of the disease, which is more often associated with multiple lesions and an earlier age of clinical presentation, the major risk factor for CMs in children seems to be radiotherapy for CNS tumors. Furthermore, a greater number of CMs coexistent with mixed angiomatous lesions have been reported in children than in adults. Surgical results are related to the preoperative neurological status of the children; symptomatic patients who are operated on early, before they develop severe neurological deficits or long-standing seizures, may achieve the best clinical outcome. Radiosurgery does not seem to be advisable in children as an alternative treatment for deep CMs or those causing epilepsy.

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Section: Resultsmentioning

confidence: 86%

Cavernous Malformations of the Central Nervous System in the Pediatric Age Group

et al. 2009

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“…Reports are infrequent, and most refer to the combination of a glioma with an arteriovenous malformation. Coexistence or subsequent development of an oligodendroglioma or astrocytoma and a cavernous angioma has been reported before [3,7,10,18,19,24,25]. We present a patient in whom an anaplastic oligo-astrocytoma developed 3 years after resection of a cerebral cavernous malformation.…”

Section: Introductionmentioning

confidence: 91%

Anaplastic oligo-astrocytoma occurring after resection of a cerebral cavernous malformation; malignant transformation? Case report and review on etiology

et al. 2009

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We report a 71-year-old woman who presented with a cerebral cavernous malformation in the right frontal lobe for which she underwent total resection. Three years later, she was admitted with seizures and neuroimaging revealed a partially calcified lesion in the area of the earlier cavernous malformation, consistent with a residual malformation. A few months later she presented with cognitive decline and neuroimaging now revealed a large mass lesion in the same area as the cavernous malformation, irregularly enhancing, spreading through the corpus callosum to the left frontal lobe. Histological examination showed an anaplastic oligo-astrocytoma. These findings suggest that cerebral cavernous malformations, or at least a subgroup, have the potential for oligodendrocytic and astrocytic transformation. Various hypotheses to explain the etiology of these rare cases are discussed.

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“…A review of the literature disclosed 41 case reports of solitary intracranial angioglioma including the current study [ 1,[3][4][5]10,12,, eight cases of two separated tumors either in the same or opposite hemispheres [26-331, and two examples of gliomas that occurred subsequently at the site of the angioma 119,341. We have not included the two latter conditions in our study, since we are concerned with combined or intermixed tumors within one lesion.…”

Section: Discussionmentioning

confidence: 99%

Combined angioma and glioma (angioglioma)

et al. 1996

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Ten patients in whom tissue proliferation akin to angioglioma occurred within the brain are described; seven of the lesions were supratentorial and three infratentorial. Only 31 accepted instances of such neoplasms have been found in the literature. The combined lesions usually become symptomatic in the second and third decades. In all 10 cases, the angiomatous part of the combined tumors showed characteristic vascular malformation such as severe hyalinization, tortuosity, and some were even calcified. The number of abnormal blood vessels were excessive in all examples. The glial portion consisted of either astrocytoma, oligodendroglioma, or mixtures of these gliomas. Dedifferentiation of the neuroglia combined with neoplastic endothelial proliferation indicates the true neoplastic nature rather than reactive gliosis associated with a vascular anomaly. © 1996 Wiley‐Liss, Inc.

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Oligodendroglioma and cerebral cavernous angioma

Cited by 31 publications

References 7 publications

Cavernous Malformations of the Central Nervous System in the Pediatric Age Group

Cavernous Malformations of the Central Nervous System in the Pediatric Age Group

Anaplastic oligo-astrocytoma occurring after resection of a cerebral cavernous malformation; malignant transformation? Case report and review on etiology

Combined angioma and glioma (angioglioma)

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