Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate

Cavaliere, Fabio; Urra, Oiane; Alberdi, Elena; Matute, Carlos

doi:10.1038/cddis.2011.144

Cited by 48 publications

(47 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, there is evidence that glutamate inhibits OPC proliferation, increases their migration speed, and inhibits their ability to differentiate into oligodendrocytes in vitro (reviewed in (Mangin and Gallo, 2011). In apparent contradiction with this idea, recent data support the notion that glutamate acting at NMDA receptors may contribute to oligodendrocyte maturation (Cavaliere et al, 2012). Despite this wealth of information, direct evidence that oligodendroglial glutamate receptors have a physiological role in regulating myelination in vivo is lacking.…”

Section: Glutamate Signaling In Axonsmentioning

confidence: 99%

Neurotransmitter signaling in white matter

Butt

Fern

Matute

2014

Glia

107

View full text Add to dashboard Cite

White matter (WM) tracts are bundles of myelinated axons that provide for rapid communication throughout the CNS and integration in grey matter (GM). The main cells in myelinated tracts are oligodendrocytes and astrocytes, with small populations of microglia and oligodendrocyte precursor cells. The prominence of neurotransmitter signaling in WM, which largely exclude neuronal cell bodies, indicates it must have physiological functions other than neuron-to-neuron communication. A surprising aspect is the diversity of neurotransmitter signaling in WM, with evidence for glutamatergic, purinergic (ATP and adenosine), GABAergic, glycinergic, adrenergic, cholinergic, dopaminergic and serotonergic signaling, acting via a wide range of ionotropic and metabotropic receptors. Both axons and glia are potential sources of neurotransmitters and may express the respective receptors. The physiological functions of neurotransmitter signaling in WM are subject to debate, but glutamate and ATP-mediated signaling have been shown to evoke Ca 21 signals in glia and modulate axonal conduction. Experimental findings support a model of neurotransmitters being released from axons during action potential propagation acting on glial receptors to regulate the homeostatic functions of astrocytes and myelination by oligodendrocytes. Astrocytes also release neurotransmitters, which act on axonal receptors to strengthen action potential propagation, maintaining signaling along potentially long axon tracts. The co-existence of multiple neurotransmitters in WM tracts suggests they may have diverse functions that are important for information processing. Furthermore, the neurotransmitter signaling phenomena described in WM most likely apply to myelinated axons of the cerebral cortex and GM areas, where they are doubtless important for higher cognitive function. GLIA 2014;62:1762-1779 Key words: glia, axon, astrocyte, oligodendrocyte, glutamate, ATP Introduction W hite matter (WM) is defined as a tract of myelinated axons-WM appears opaque or dense due to the fatty myelin in anatomical sections and in brain scans. Notwithstanding this, myelination is not restricted to WM and is also critical to rapid communication and integration in grey matter (GM) areas, such as in axons in the cortical GM and hippocampus. Hence, many aspects of neurotransmitter signaling to be covered in this review have resonance in GM and higher cognitive function. Indeed, in the human brain WM is a prominent feature of the cerebral cortex, the seat of higher intelligence. Myelination of GM is also evident in rodents, but discrete WM tracts are not pronounced in the cerebral cortex. As a general concept, WM are simply concentrations of myelinated axons bundled together into tracts that interconnect areas of GM. The molecular physiology of myelinated axons will be very similar in WM and GM, and they will be subject to the same neurotransmitter signaling phenomena that is the subject of this review. The main cells associated with myelinated axons are the myelinating oligodendro...

show abstract

Section: Glutamate Signaling In Axonsmentioning

confidence: 99%

Neurotransmitter signaling in white matter

Butt

Fern

Matute

2014

Glia

107

View full text Add to dashboard Cite

show abstract

“…But it is becoming evident that like other mediators in the neuroscience of disease, ROS can be detrimental or beneficial, depending on concentration and cellular context [67]. For example, low levels of ROS promote OPC migration [68] and oligodendrocyte differentiation and myelin formation [69], and homeostatic levels of nitric oxide may support EPC function [70]. Recently, there is an important movement to more carefully define not only sources but also different types of radicals [71].…”

Section: Oxidative Stressmentioning

confidence: 99%

Mechanisms of Neurovascular Dysfunction in Acute Ischemic Brain

Terasaki¹,

Liu²,

Hayakawa³

et al. 2014

CMC

View full text Add to dashboard Cite

The neurovascular unit is now well accepted as a conceptual framework for investigating the mechanisms of ischemic stroke. From a molecular and cellular perspective, three broad mechanisms may underlie stroke pathophysiology – excitotoxicity, oxidative stress and inflammation. To date, however, most investigations of these basic mechanisms have focused on neuronal responses. In this mini-review, we ask whether these mechanisms of excitotoxicity, oxidative stress and inflammation can also be examined in terms of non-neuronal interactions in the neurovascular unit, including the release of extracellular vesicles for cell-cell signaling.

show abstract

“…34 In particular, pro-oxidants also modulate oligodendrocyte development. 35,36 The notion that a redox dysregulation during critical periods of neurodevelopment could alter structural and functional connectivity has not yet been established. We propose that abnormal redox control could contribute to the white matter anomalies observed in schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients

et al. 2014

View full text Add to dashboard Cite

Schizophrenia pathophysiology implies both abnormal redox control and dysconnectivity of the prefrontal cortex, partly related to oligodendrocyte and myelin impairments. As oligodendrocytes are highly vulnerable to altered redox state, we investigated the interplay between glutathione and myelin. In control subjects, multimodal brain imaging revealed a positive association between medial prefrontal glutathione levels and both white matter integrity and resting-state functional connectivity along the cingulum bundle. In early psychosis patients, only white matter integrity was correlated with glutathione levels. On the other side, in the prefrontal cortex of peripubertal mice with genetically impaired glutathione synthesis, mature oligodendrocyte numbers, as well as myelin markers, were decreased. At the molecular levels, under glutathione-deficit conditions induced by short hairpin RNA targeting the key glutathione synthesis enzyme, oligodendrocyte progenitors showed a decreased proliferation mediated by an upregulation of Fyn kinase activity, reversed by either the antioxidant N-acetylcysteine or Fyn kinase inhibitors. In addition, oligodendrocyte maturation was impaired. Interestingly, the regulation of Fyn mRNA and protein expression was also impaired in fibroblasts of patients deficient in glutathione synthesis. Thus, glutathione and redox regulation have a critical role in myelination processes and white matter maturation in the prefrontal cortex of rodent and human, a mechanism potentially disrupted in schizophrenia.

show abstract

Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate

Cited by 48 publications

References 29 publications

Neurotransmitter signaling in white matter

Neurotransmitter signaling in white matter

Mechanisms of Neurovascular Dysfunction in Acute Ischemic Brain

Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients

Contact Info

Product

Resources

About