Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity

Miyazaki, Yuri; Otsuka, Takeshi; Yamagata, Yoko; Endo, Toshihiro; Sanbo, Makoto; Sano, Hiromi; Kobayashi, Kenta; Inahashi, Hiroki; Kornau, Hans-Christian; Schmitz, Dietmar; Prüss, Harald; Meijer, Dies; Hirabayashi, Masumi; Fukata, Yuko; Fukata, Masaki

doi:10.1016/j.celrep.2023.113634

Cited by 4 publications

(1 citation statement)

References 90 publications

(151 reference statements)

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“…Importantly, this study demonstrated that levels of ADAM22 could be maintained through increased interaction with 14-3-3 following phosphorylation of ADAM22 by protein kinase A ( Yokoi et al, 2021 ). Other studies have continued to show functional interactions between these ADAM proteins and Kv1 channels and LGI family proteins leading to regulation of axon physiology and synaptic plasticity ( Lovero et al, 2015 ; Hivert et al, 2019 ; Kozar-Gillan et al, 2023 ; Miyazaki et al, 2024 ). ADAM11 has also been shown to play a role in Xenopus neural tube closure and cranial neural crest cell migration through its interaction with Wnt and BMP4 pathway proteins, and to serve as a ligand for integrin alpha4, thus supporting cell adhesion as do other ADAM proteins ( Wang et al, 2018 ; Pandey et al, 2023 ).…”

Section: M12 Adamsmentioning

confidence: 99%

Inactive metallopeptidase homologs: the secret lives of pseudopeptidases

Lyons

2024

Front. Mol. Biosci.

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Inactive enzyme homologs, or pseudoenzymes, are proteins, found within most enzyme families, that are incapable of performing catalysis. Rather than catalysis, they are involved in protein-protein interactions, sometimes regulating the activity of their active enzyme cousins, or scaffolding protein complexes. Pseudoenzymes found within metallopeptidase families likewise perform these functions. Pseudoenzymes within the M14 carboxypeptidase family interact with collagens within the extracellular space, while pseudopeptidase members of the M12 “a disintegrin and metalloprotease” (ADAM) family either discard their pseudopeptidase domains as unnecessary for their roles in sperm maturation or utilize surface loops to enable assembly of key complexes at neuronal synapses. Other metallopeptidase families contain pseudopeptidases involved in protein synthesis at the ribosome and protein import into organelles, sometimes using their pseudo-active sites for these interactions. Although the functions of these pseudopeptidases have been challenging to study, ongoing work is teasing out the secret lives of these proteins.

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Section: M12 Adamsmentioning

confidence: 99%

Inactive metallopeptidase homologs: the secret lives of pseudopeptidases

Lyons

2024

Front. Mol. Biosci.

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Synapse and primary cilia dysfunctions in Autism Spectrum Disorders. Avenues to normalize these functions

Hauw,

Hausser-Hauw,

Barthélémy

2024

Revue Neurologique

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Overabundant endocannabinoids in neurons are detrimental to cognitive function

Zhu,

Zhang,

et al. 2024

Preprint

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2-Arachidonoylglycerol (2-AG) is the most prevalent endocannabinoid involved in maintaining brain homeostasis. Previous studies have demonstrated that inactivating monoacylglycerol lipase (MAGL), the primary enzyme responsible for degrading 2-AG in the brain, alleviates neuropathology and prevents synaptic and cognitive decline in animal models of neurodegenerative diseases. However, we show that selectively inhibiting 2-AG metabolism in neurons impairs cognitive function in mice. This cognitive impairment appears to result from decreased expression of synaptic proteins and synapse numbers, impaired long-term synaptic plasticity and cortical circuit functional connectivity, and diminished neurogenesis. Interestingly, the synaptic and cognitive deficits induced by neuronal MAGL inactivation can be counterbalanced by inhibiting astrocytic 2-AG metabolism. Transcriptomic analyses reveal that inhibiting neuronal 2-AG degradation leads to widespread changes in expression of genes associated with synaptic function. These findings suggest that crosstalk in 2-AG signaling between astrocytes and neurons is crucial for maintaining synaptic and cognitive functions and that excessive 2-AG in neurons alone is detrimental to cognitive function.

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Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity

Cited by 4 publications

References 90 publications

Inactive metallopeptidase homologs: the secret lives of pseudopeptidases

Inactive metallopeptidase homologs: the secret lives of pseudopeptidases

Synapse and primary cilia dysfunctions in Autism Spectrum Disorders. Avenues to normalize these functions

Overabundant endocannabinoids in neurons are detrimental to cognitive function

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