Oligoaniline-based conductive biomaterials for tissue engineering

Zarrintaj, Payam; Bakhshandeh, Behnaz; Saeb, Mohammad Reza; Sefat, Farshid; Rezaeian, Iraj; Ganjali, Mohammad Reza; Ramakrishna, Seeram; Mozafari, Masoud

doi:10.1016/j.actbio.2018.03.042

Cited by 124 publications

(67 citation statements)

References 128 publications

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“…The sample was rinsed completely with PBS to remove any residual medium, and then the cells were fixed at room temperature for 2 h using 2.5% glutaraldehyde. [40] The nucleus was then stained using a solution of DAPI (10 µg mL −1 ) in DI water for 5 min. [39] The dehydrated samples were sputter-coated with gold (to a thickness of 10 nm) prior to SEM observation.…”

Section: Wwwadvmatinterfacesdementioning

confidence: 99%

Poly(3,4‐ethylenedioxythiophene) Polymer Composite Bioelectrodes with Designed Chemical and Topographical Cues to Manipulate the Behavior of PC12 Neuronal Cells

Tsai

She

et al. 2019

Adv Materials Inter

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Controlled extracellular chemical and topographical cues can generate physicochemical changes that influence the proliferation and differentiation of neural cells; external electrical stimulation (ES) via conductive bioelectrodes can promote neural differentiation by increasing neurite outgrowth. Rat pheochromocytoma (PC12) cells are used as a neuron‐like model cells to explore the possibility of using a well‐designed poly(ethylene oxide) (PEO)/poly(3,4‐ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS) blend solution to fabricate functional bioelectrodes presenting biological fouling/antifouling surfaces, thereby regulating the cell adhesion, proliferation, and differentiation properties. In this study, it is found that a flat PEO/PEDOT:PSS composite film fabricates through spin‐coating, operates through a contact repulsion mechanism that limits cell attachment and proliferation; in contrast, the aligned and random PEO/PEDOT:PSS nanofibers fabricates through electrospinning promoted neuron adhesion efficiently and allows manipulation of the cell morphology. Furthermore, ES of PC12 cells is performed to investigate the influence of the conductive random and aligned PEO/PEDOT:PSS composite nanofiber mats on the enhancement of neurite outgrowth, as well as the relative gene expression of Nestin, Tuj1, and MAP2. Therefore, combining this unique PEDOT:PSS blend solution with various fabrication processes appears to be a facile approach toward bioelectronic interface coatings displaying tunable surface properties for manipulating the cellular behavior of neurons during ES.

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Section: Wwwadvmatinterfacesdementioning

confidence: 99%

Poly(3,4‐ethylenedioxythiophene) Polymer Composite Bioelectrodes with Designed Chemical and Topographical Cues to Manipulate the Behavior of PC12 Neuronal Cells

Tsai

She

et al. 2019

Adv Materials Inter

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“…One issue relates to making large, even, and defect free films on transparent electrodes that are sufficient for device applications. [17][18][19][20][21] Introducing oligoanilines in a variety of polymeric architectures can endow them with attractive electroactivity and stimuli-responsiveness, while featuring superior solubility, processability, and tunability. This should result in a robust silica/organic composite with characteristics determined by the electroactive units chosen.…”

Section: Introductionmentioning

confidence: 99%

Flexible and Robust Electro‐Optically Responsive Films Based on Novel Silica/Oligoaniline/Carbon Dots Composite

Zhou

Berda

et al. 2019

ChemElectroChem

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We report a new electro-optical composite film based on silica, oligoaniline, and carbon dots prepared by a hydrolytic crosslinking reaction under electrokinetic potentials. The electroactive oligoaniline and fluorescent carbon dots are covalently linked through hydrolysis of siloxane, resulting in multifunctional composite films. The resultant crosslinked architecture endows the films with high flexibility and robust durability. These films display good electrochromic behavior with an obvious color contrast, quick switching rate, and acceptable cycling stability. Moreover, these films reveal an interesting electrofluorochromic performance in continuous potential ranges, attributed to the interaction between oligoaniline and carbon dots, and the change in structure that occurs with changing redox potentials. Further, an enhanced photocurrent response is observed in these materials, as a result of the organic-inorganic interfaces.

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“…Fibroblast cells demonstrate good adhesion and growth on the hydrogel surfaces. Many efforts have been devoted to the development of EHs as 3D scaffold of tissues (Mawad et al, ; Sasaki et al, ; Zarrintaj et al, ; X. Zhao, Li, Guo, & Ma, ), which have great promise for use as conducting substrates for the growth of electro‐responsive cells in tissue engineering. A thorough review of conducting polymers for tissue engineering application has been published by Ma, where bone tissue engineering, muscle tissue engineering, nerve tissue engineering, cardiac tissue engineering, and wound healing application are discussed in detail (B. Guo & Ma, ).…”

Section: Ehs For Biomedical Applicationsmentioning

confidence: 99%

Electroconductive hydrogels for biomedical applications

Han

Zhang

2019

WIREs Nanomed Nanobiotechnol

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Electroconductive hydrogels (EHs), combining both the biomimetic features of hydrogels and the electrochemical properties of conductive polymers and carbon‐based materials, have received immense considerations over the past decade. The three‐dimensional porous structure, hydrophilic properties, and regulatable chemical and physical properties of EH resemble the extracellular matrix in tissues, enable EHs a good matrix for cell growth, proliferation, and migration. Different from nonconductive hydrogels, EHs possess high electrical conductivity and electrochemical redox properties, which can be utilized to detect electric signals generated in biological systems, and also to supply electrical stimulation to regulate the activity and function of cells and tissues. Hence, this article provides a summary of the new development of EH for biomedical applications in the decade. We give a brief introduction of the design and synthesis of EHs, as well as current applications of EHs in biomedical fields, including cell culture, tissue engineering, drug delivery and controlled release, biosensors, and implantable bioelectronics. The development trends and challenges of EHs for biomedical applications are also discussed. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Diagnostic Tools > Biosensing Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Oligoaniline-based conductive biomaterials for tissue engineering

Cited by 124 publications

References 128 publications

Poly(3,4‐ethylenedioxythiophene) Polymer Composite Bioelectrodes with Designed Chemical and Topographical Cues to Manipulate the Behavior of PC12 Neuronal Cells

Poly(3,4‐ethylenedioxythiophene) Polymer Composite Bioelectrodes with Designed Chemical and Topographical Cues to Manipulate the Behavior of PC12 Neuronal Cells

Flexible and Robust Electro‐Optically Responsive Films Based on Novel Silica/Oligoaniline/Carbon Dots Composite

Electroconductive hydrogels for biomedical applications

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