Oligo-glycerol based non-ionic amphiphilic nanocarriers for lipase mediated controlled drug release

Abstract

A new series of oligo-glycerol based amphiphiles have been synthesized for drug delivery.

Self-assembly of carbohydrate-based small amphiphiles and their applications in pathogen inhibition and drug delivery: a review

“…Furthermore, the lectin binding ability was found to be sensitive towards the nature of the calixarene scaffold. The calix [4]arene skeleton had higher inhibition potential than conformationally mobile calix [8]arene. Ungaro et al reported glycocalixarenes that consisted of glucose units at the upper rim of calix [6]arene (16a) and calix [8]arene (16b), whereas the lower rim was occupied with the methyl groups (Fig.…”

“…63 The synthesized amphiphilic macrocycles selfassembled into stable vesicular aggregates in an aqueous solution that responded to pH change. The calix [8]GlcNAc and calix [8]GlyGlcNAc formed aggregates of average hydrodynamic radius of 110 nm and 200 nm, respectively revealed by static and dynamic light scattering methods. In addition, the effect of pH on the aggregation behaviour was studied with both nanostructures, as pH decreased from 7 to 3, the diameter of the aggregate of both amphiphiles decreased to 5 nm with the transition in structure from vesicle to micelles.…”

“…Sgarlata et al reported the synthesis of calixarene-based glycoconjugates (15a-15f, Fig. 15) using calix [4]arene and calix [8]arene as core and GlcNAc as…”

“…Geraci et al investigated the self-assembly behaviour of calix [8]GlcNAc (25a) and calix [8]GlyGlcNAc (25b) (Fig. 25) at different pH and demonstrated their application as drug nanocarrier.…”

“…[1][2][3][4][5] Besides polymeric amphiphiles, non-polymeric small amphiphiles too have gained considerable attention owing to precise control over their molecular weight, polydispersity, and hydrophobic-lipophilic balance (HLB). [6][7][8][9] Moreover, these aggregate into well-defined constructions, instead of a mixture of various compositions. 9 Self-assembly of amphiphiles produces different structures ranging from micelles, helices, fibers to tubes and vesicles.…”