Oligo-anovulation is not a rarer feature in women with documented endometriosis

Santulli, Piétro; Tran, Chloé; Gayet, Vanessa; Maignien, Chloé; Marcellin, Louis; Pocate-Cheriet, Khaled; Chapron, Charles; Ziegler, Dominique de

doi:10.1016/j.fertnstert.2018.06.012

Cited by 11 publications

(3 citation statements)

References 46 publications

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“…Endometriosis is a gynecological disorder affecting 10% to 15% of women in reproductive age; up to 70% of the patients have pelvic pain and 48% have fertility problems [1,2]. The disease is characterized by the presence of stromal and/or endometrial glandular epithelium outside the uterus and is classified in three different types: superficial, ovarian and deep endometriosis [3][4][5]. Endometriosis was first described in the seventeenth century and, despite all research efforts in the last 30 years, its pathogenesis is still unclear [6].…”

Section: Introductionmentioning

confidence: 99%

Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and Lesion

Hernandes

Silveira²,

Sereia³

et al. 2020

Diagnostics

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This work aimed to identify and compare the bacterial patterns present in endometriotic lesions, eutopic endometrium and vaginal fluid from endometriosis patients with those found in the vaginal fluid and eutopic endometrium of control patients. Vaginal fluid, eutopic endometrium and endometriotic lesions were collected. DNA was extracted and the samples were analyzed to identify microbiome by high-throughput DNA sequencing of the 16S rRNA marker gene. Amplicon sequencing from vaginal fluid, eutopic endometrium and endometriotic lesion resulted in similar profiles of microorganisms, composed most abundantly by the genus Lactobacillus, Gardnerella, Streptococcus and Prevotella. No significant differences were found in the diversity analysis of microbiome profiles between control and endometriotic patients; however deep endometriotic lesions seems to present different bacterial composition, less predominant of Lactobacillus and with more abundant Alishewanella, Enterococcus and Pseudomonas.

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Section: Introductionmentioning

confidence: 99%

Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and Lesion

Hernandes

Silveira²,

Sereia³

et al. 2020

Diagnostics

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“…The average MCL was used in several women who had different lengths of the cycle (for example, 28 days in this cycle and 29 days in the next cycle). Cycles with MCL < 26 days were defined as short cycles and MCL > 35 days was defined as oligo/amenorrhea according to previous studies ( 18 , 22 , 23 ). A cycle length of 26-35 days was considered as a normal cycle in this study.…”

Section: Methodsmentioning

confidence: 99%

Oligo/Amenorrhea Is an Independent Risk Factor Associated With Low Ovarian Response

Gan

Ying

et al. 2021

Front. Endocrinol.

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CapsuleOligo/amenorrhea is an independent risk factor of low ovarian response but not high ovarian response, particularly in women with low AMH levels.ObjectiveTo investigate the association of menstrual cycle length (MCL) with anti-Müllerian hormone (AMH) and ovarian response.MethodsThis was a retrospective cohort study. A total of 7471 women who underwent ovarian stimulation and oocyte retrieval were enrolled. The main outcome was the number of oocytes retrieved.Main ResultsA total of 5734 patients were eligible for analysis. In women without polycystic ovary syndrome (PCOS), serum AMH levels and antral follicle count were significantly lower in women with short cycles and higher in women with oligo/amenorrhea than those with a normal menstrual cycle. In women with PCOS, compared to women with a normal menstrual cycle, women with short cycles and women with oligo/amenorrhea showed higher antral follicle count and higher serum AMH levels. Compared with the 0-25th range group of AMH levels, 75-100th percentile groups showed a significantly increased rate of oligo/amenorrhea in women with and without PCOS [adjusted odds ratio (OR) =1.9 (1.04, 3.46), 2.4 (1.70, 3.35)]. In women without PCOS, the low ovarian response was more common in women with short cycles and less common in women with oligo/amenorrhea compared to women with normal cycles [OR=3.0 (2.38, 3.78), 0.7 (0.55, 0.96), respectively]. When adjusted for AMH levels, both short cycles and oligo/amenorrhea were associated with an increased risk of low response [adjusted OR=1.3 (1.02, 1.75), 1.3 (0.93, 1.86), respectively]. In women without PCOS and with low AMH levels, the low ovarian response was more common in women with short cycles as well as in women with oligo/amenorrhea [OR=1.5 (1.08, 1.98), 1.7 (1.08, 2.69), adjusted OR=1.2 (0.86, 1.74), 2.2 (1.31, 3.82), respectively].ConclusionAMH levels are significantly associated with increased risk of oligo/amenorrhea in women with and without PCOS. AMH is an indispensable confounder in the association between MCL and ovarian response in women without PCOS. Oligo/amenorrhea is an independent risk factor associated with a low ovarian response in women without PCOS, particularly those with low AMH levels.

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“…The pathogenesis and histological findings are characterized by endometrial glandular and stromal tissue growing beyond the uterus. It is classified into three types: superficial, ovarian, and deep endometriosis [3,4]. Although it is not considered a malignant disease, it can cause debilitating symptoms such as dysmenorrhea, dyspareunia, dysuria, and dyschezia (the 4-D's) (Figure 1A) [5], and it may affect the fertility, psychological well-being, and social functioning of the patients.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota and Endometriosis: Exploring the Relationship and Therapeutic Implications

Xholli,

Cremonini,

Perugi

et al. 2023

Pharmaceuticals

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Endometriosis is a common inflammatory disease affecting women of reproductive age, characterized by the growth of endometrial tissue beyond the uterus. In addition to gynecological manifestations, many endometriosis patients experience gastrointestinal symptoms, indicating a potential association between gut health and the disease. Recent studies have revealed alterations in the gut microbiota of individuals with endometriosis, including reduced diversity, microbial composition imbalances, and pathogenic bacteria. These changes can disrupt immune function, increase inflammation, and contribute to the chronic inflammatory state observed in endometriosis. Moreover, dysregulation of intestinal permeability may further exacerbate gastrointestinal symptoms in affected individuals. Understanding the role of the gut microbiota and intestinal permeability in endometriosis can provide valuable insights into disease pathogenesis, aid in non-invasive diagnostic approaches, and open new avenues for therapeutic interventions. Probiotics, in particular, have shown promise in improving endometriosis-associated pain symptoms and reducing endometriotic lesions in animal models. This review suggests that additional research and well-designed clinical trials are necessary to validate the potential diagnostic and therapeutic benefits of manipulating the gut microbiota in managing endometriosis and its gastrointestinal symptoms, thereby improving the quality of life for those affected.

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Oligo-anovulation is not a rarer feature in women with documented endometriosis

Cited by 11 publications

References 46 publications

Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and Lesion

Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and Lesion

Oligo/Amenorrhea Is an Independent Risk Factor Associated With Low Ovarian Response

Gut Microbiota and Endometriosis: Exploring the Relationship and Therapeutic Implications

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