Oligo-3-hydroxybutyrates as potential carriers for drug delivery

Piddubnyak, V.; Kurcok, Piotr; Matuszowicz, Andrzej; Głowala, Magdalena; Fiszer-Kierzkowska, Anna; Jedliński, Zbigniew; Juzwa, Maria; Krawczyk, Z

doi:10.1016/j.biomaterials.2003.12.029

Cited by 68 publications

(48 citation statements)

References 39 publications

(46 reference statements)

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“…Recent novel examples, many of which are not polymer-based, include calcium carbonate [31], calcium-deficient hydroxyapatite [32], chitosan [33], oligo-3-hydroxybutyrates [34] and porous hollow silica [35]. Polymer micelles have emerged as a very important system for targeted drug delivery.…”

Section: Nanoparticlesmentioning

confidence: 99%

Nanostructured materials for applications in drug delivery and tissue engineering

Goldberg

Langer

Jia

2007

Journal of Biomaterials Science, Polymer Edition

943

554

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Research in the areas of drug delivery and tissue engineering has witnessed tremendous progress in recent years due to their unlimited potential to improve human health. Meanwhile, the development of nanotechnology provides opportunities to characterize, manipulate and organize matter systematically at the nanometer scale. Biomaterials with nano-scale organizations have been used as controlled release reservoirs for drug delivery and artificial matrices for tissue engineering. Drug-delivery systems can be synthesized with controlled composition, shape, size and morphology. Their surface properties can be manipulated to increase solubility, immunocompatibility and cellular uptake. The limitations of current drug delivery systems include suboptimal bioavailability, limited effective targeting and potential cytotoxicity. Promising and versatile nano-scale drug-delivery systems include nanoparticles, nanocapsules, nanotubes, nanogels and dendrimers. They can be used to deliver both small-molecule drugs and various classes of biomacromolecules, such as peptides, proteins, plasmid DNA and synthetic oligodeoxynucleotides. Whereas traditional tissue-engineering scaffolds were based on hydrolytically degradable macroporous materials, current approaches emphasize the control over cell behaviors and tissue formation by nano-scale topography that closely mimics the natural extracellular matrix (ECM). The understanding that the natural ECM is a multifunctional nanocomposite motivated researchers to develop nanofibrous scaffolds through electrospinning or self-assembly. Nanocomposites containing nanocrystals have been shown to elicit active bone growth. Drug delivery and tissue engineering are closely related fields. In fact, tissue engineering can be viewed as a special case of drug delivery where the goal is to accomplish controlled delivery of mammalian cells. Controlled release of therapeutic factors in turn will enhance the efficacy of tissue engineering. From a materials point of view, both the drug-delivery vehicles and tissue-engineering scaffolds need to be biocompatible and biodegradable. The biological functions of encapsulated drugs and cells can be dramatically enhanced by designing biomaterials with controlled organizations at the nanometer scale. This review summarizes the most recent development in utilizing nanostructured materials for applications in drug delivery and tissue engineering.

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Section: Nanoparticlesmentioning

confidence: 99%

Nanostructured materials for applications in drug delivery and tissue engineering

Goldberg

Langer

Jia

2007

Journal of Biomaterials Science, Polymer Edition

943

554

View full text Add to dashboard Cite

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“…We compared the transfection efficiency of each complex in mouse melanoma cell lines, B16-F10 cells, which are often used to examine the basic gene expression of non-viral vectors [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

γ-Polyglutamic acid-coated vectors for effective and safe gene therapy

Kurosaki

Kitahara

Kawakami

et al. 2010

Journal of Controlled Release

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“…The atactic analogue of PHB (a-PHB) is a totally amorphous biomimetic polymer that can be easily obtained via polymerization of (R,S)-b-butyrolactone (BL). [3][4][5] Both isomers are biocompatible and bioresorbable, [6][7][8] however, their drawback for eventual applications in regenerative medicine is poor hydrophilicity. One of the best known hydrophilic polymers is poly(ethylene glycol) (PEG), commonly approved for medical applications.…”

Section: Introductionmentioning

confidence: 99%