Olfactory Stimulation Prevents Apnea in Premature Newborns

Marlier, Luc; Gaugler, Christophe; Messer, J

doi:10.1542/peds.2004-0865

Cited by 91 publications

(70 citation statements)

References 46 publications

(40 reference statements)

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“…Finally, the observational study of Marlier et al [36] in 14 preterm newborns (24th-28th gestational week) with recurrent apnea despite caffeine and doxapram therapy, found that an exposition to a specific (pleasant according to the authors) odor diffused during 24 h in the incubator resulted in a diminution of apneas of 36% in 12 of the 14 participants. In addition, apneas without bradycardia were also reduced by 44% during the day with odorization.…”

Section: Aromatherapymentioning

confidence: 95%

Systematic Review on Phytotherapy in Neonatology

Thiel

Längler²,

Ostermann³

2011

Forsch Komplementmed

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Background: There is an enormous economical significance of phytotherapy at least in Germany, the huge demand of patients was repeatedly proven. Simultaneously data exist for different application areas and ages as for younger children and pregnancy until birth. The actual neonatal period can be of interest because phytotherapy is used in younger children and until birth, it is not very likely that there is a gap in this period of life. Aim: To give an overview on the current literature on phytotherapy in neonatology. Methods: A systematic review was performed in the following databases: Cochrane, EM-BASE Alert, AMED, NCCAM, NLM, DIMDI, CAMbase, BIOSIS Previews, DAHTA, SciSearch, and Medline as well as in the archives of GMS, Karger, Kluwer, Thieme, Krause and Pachernegg, Wiley-Interscience/Phytotherapy Research, Springer and Merkurstab publishers. Keywords were neonatology, newborn, preterm, phytotherapy, phytomedicine, and herbal drugs in clinical randomized controlled studies. Results: We found 14 articles that fulfilled the inclusion criteria: 10 case control studies, 1 observational study, 1 study with interview, 1 with a questionnaire, and 1 retrospective study. Topics were aromatherapy, external applications, and internal effects of herbal teas. Conclusion: Indications, study design and explantory power of these publications were quite heterogeneous. Most promising was the study situation in aromatherapy. Due to the fact that phytotherapy is frequently used and there is a high demand of parents, methodologically excellent studies are needed to evaluate the significance of phytotherapy in the neonatal period. The aim is to fulfill scientific as well as economical needs. This review shows that there is no such evidence yet.

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Section: Aromatherapymentioning

confidence: 95%

Systematic Review on Phytotherapy in Neonatology

Thiel

Längler²,

Ostermann³

2011

Forsch Komplementmed

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“…In a group of 14 infants with GA 24-28 weeks who were unresponsive to both caffeine and doxapram, it was found that exposure to 15 drops of saturated vanillin solution applied on the periphery of the infant's pillow led to a 45% reduction in the frequency of apnea associated with bradycardia. 53 …”

Section: Olfactory Stimulationmentioning

confidence: 99%

Apnea of prematurity: challenges and solutions

Picone¹,

Aufieri²,

Paolillo³

2014

RRN

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Apnea of prematurity is a developmental disorder that frequently affects preterm infants, especially those with lower gestational age. Even if apnea of prematurity is by definition a self-limiting condition, it can cause serious problems during the hospital stay and can potentially have long-term neurological and cognitive consequences depending on the severity and intensity of the episodes. The diagnosis of apnea of prematurity can be made only after excluding a number of diseases of the preterm infant in which apnea may be an epiphenomenon. Etiological diagnosis is essential for selection of appropriate treatment, which may be nonpharmacological or involve use of drugs.

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“…A novel therapy in the form of olfactory stimulation in premature infants with apnea and bradycardia was reported by Marlier et al 97 They investigated the effects of a pleasant odor in preterm infants with apnea and bradycardia that were refractory to caffeine and doxapram. Introduction of a pleasant odor into the incubator reduced the incidence of apnea and bradycardia significantly in this group of preterm infants.…”

Section: Other Therapiesmentioning

confidence: 99%

Apnea of prematurity: pathogenesis and management strategies

Mathew

2010

J Perinatol

103

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Apnea of prematurity (AOP) is a significant clinical problem manifested by an unstable respiratory rhythm reflecting the immaturity of respiratory control systems. This review will address the pathogenesis of and treatment strategies for AOP. Although the neuronal mechanisms leading to apnea are still not well understood, recent decades have provided better insight into the generation of the respiratory rhythm and its modulation in the neonate. Ventilatory responses to hypoxia and hypercarbia are impaired and inhibitory reflexes are exaggerated in the neonate. These unique vulnerabilities predispose the neonate to the development of apnea. Treatment strategies attempt to stabilize the respiratory rhythm. Caffeine remains the primary pharmacological treatment modality and is presumed to work through blockade of adenosine receptors A 1 and A 2 . Recent evidences suggest that A 2A receptors may have a greater role than previously thought. AOP typically resolves with maturation suggesting increased myelination of the brainstem.

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Olfactory Stimulation Prevents Apnea in Premature Newborns

Abstract: The introduction of a pleasant odor in the incubator is of therapeutic value in the treatment of apneas unresponsive to caffeine and doxapram.

Cited by 91 publications

References 46 publications

Systematic Review on Phytotherapy in Neonatology

Systematic Review on Phytotherapy in Neonatology

Apnea of prematurity: challenges and solutions

Apnea of prematurity: pathogenesis and management strategies

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