Olfactory projection systems, drugs and behaviour: A review

Cairncross, K.D.; Cox, B.; Förster, Christine; Wren, A.

doi:10.1016/0306-4530(79)90009-x

Cited by 112 publications

(39 citation statements)

References 46 publications

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“…The observation that mianserin attenuates the hyper activity of OB rats in the 'open field' confirms the find ings of Caimcross et al [1979] and Jancsdr and Leonard [ 1984]. However, neither of the metabolites of mianserin showed activity when administered in the same dose under the same conditions as the parent compound.…”

Section: Discussionsupporting

confidence: 70%

The Effect of Chronically Administered Mianserin, 8-Hydroxymianserin and Desmethylmianserin on the ‘Open Field’ Behaviour and Brain Noradrenaline Metabolism in the Olfactory Bulbectomized Rat

Leonard

O’Connor

1987

Neuropsychobiology

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The chronic effects of mianserin and two of its major metabolites on the behaviour of olfactory bulbectomized rats in the ‘open field’ apparatus were studied. When these compounds were tested at the same dose, only the parent compound was active in attenuating the hypermotility which the bulbectomized rat exhibited under these experimental conditions. Changes in the concentrations of noradrenaline and 3-methoxy-4-hydroxyphenylglycol (MHPG) were also determined in the amygdaloid cortex and mid-brain regions of the sham-operated and lesioned rats. Only mianserin reversed the reduction in the noradrenaline concentration which occurred in the amygdaloid cortex following bulbectomy; the changes in noradrenaline or MHPG in the mid-brain were not correlated with this behavioural effect of mianserin.

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Section: Discussionsupporting

confidence: 70%

The Effect of Chronically Administered Mianserin, 8-Hydroxymianserin and Desmethylmianserin on the ‘Open Field’ Behaviour and Brain Noradrenaline Metabolism in the Olfactory Bulbectomized Rat

Leonard

O’Connor

1987

Neuropsychobiology

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“…Consequently, the OBX syndrome is believed to result from dysfunction in brainstem and limbic areas involving a variety of neurochemical and neuropharmacological changes affecting many different transmitter systems (Pohorecky et al 1969;Hirsh 1980;Janscar and Leonard 1984;Tiong and Richardson 1990;Gurevich et al 1993). Numerous studies have also demonstrated that many of the behavioral and biochemical alterations invoked by OBX are reversed by chronic administration of most antidepressant drugs (Van Riezen et al 1976;Cairncross et al 1978Cairncross et al , 1979aJesberger and Richardson 1986;Kelly et al 1997).…”

Section: Introductionmentioning

confidence: 96%

Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat

2000

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“…Several studies have demonstrated important changes in neurotransmitters in OB rats, i.e., reduction of NA and 5-HT brain concentrations, in contrast increasing gammaaminobutyric acid (GABA) turnover in the amygdaloid cortex (Jancsár and Leonard 1984;van Riezen and Leonard 1990). Moreover, the data available in the literature have demonstrated that most of the above-mentioned behavioral and biochemical changes observed in OB rats are reversed by chronic antidepressant treatments in the OF test (Cairncross et al 1979;van Riezen and Leonard 1990;Kelly et al 1997). These findings have been independently confirmed by active and/or passive avoidance studies in OB rats (Hand et al 1991).…”

Section: Discussionmentioning

confidence: 93%

Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats

Jastrzębska-Więsek

Siwek

Partyka

et al. 2015

Naunyn-Schmiedeberg's Arch Pharmacol

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The study was designed to examine the potency of EMD 386088, a 5-HT6 receptor partial agonist, to exert antidepressant-like properties in animal models following acute and chronic intraperitoneal administration to rats. The modified rat forced swim test (FST) was utilized to examine a potential antidepressant effect of EMD 386088 after acute treatment (30 min before the test) and three times in a 24-h administration scheme (24 h, 5 h, and 30 min prior to the FST). The olfactory bulbectomy (OB) model was used to assess its antidepressant-like properties after chronic treatment (the drug was administered once daily for 14 days). EMD 386088 showed an antidepressant-like effect in all conducted tests. Its activity in FST after its acute administration (5 mg/kg) was blocked by the selective 5-HT6 receptor antagonist SB 271046. The obtained results seem to be specific, as there was no observed locomotor stimulation by the drug given at a lower/antidepressant dose. In the three times in the 24-h treatment scheme, EMD 386088 (2.5 mg/kg) exerted antidepressant properties in FST as well as increased locomotor activity in the open field test. Chronic administration of EMD 386088 (2.5 mg/kg) significantly improved the learning deficit in OB rats without affecting performance in Sham-operated (SH) animals in the passive avoidance test, and reduced OB-related rats' locomotor hyperactivity, but did not change the number of rearing + peeping episodes. The obtained findings suggest that EMD 386088 produces antidepressant-like activity after systemic acute and chronic administration which may result from direct stimulation of 5-HT6 receptors.

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Olfactory projection systems, drugs and behaviour: A review

Cited by 112 publications

References 46 publications

The Effect of Chronically Administered Mianserin, 8-Hydroxymianserin and Desmethylmianserin on the ‘Open Field’ Behaviour and Brain Noradrenaline Metabolism in the Olfactory Bulbectomized Rat

The Effect of Chronically Administered Mianserin, 8-Hydroxymianserin and Desmethylmianserin on the ‘Open Field’ Behaviour and Brain Noradrenaline Metabolism in the Olfactory Bulbectomized Rat

Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat

Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats

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