Olfactory Neuroblastoma

Veyrat, M.; Vérillaud, Benjamin; Fiaux-Camous, Domitille; Froelich, Sébastien; Bresson, D.; Nicolai, Piero; Herman, Philippe

doi:10.1159/000457935

Cited by 9 publications

(9 citation statements)

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“…Modified Kadish stage and Hymans pathological grade are widely used in clinical practice, both of which can provide important guidance for prognosis and treatment of ONB ( 30 ). Combined therapy is a widely accepted treatment scheme for ONB at present ( 31 ). In terms of improving survival rate and reducing local recurrence rate, surgical resection combined with postoperative radiotherapy usually achieves better results ( 32 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

Persistent pain and numbness in the extremities of an adult due to paraneoplastic peripheral neuropathy caused by olfactory neuroblastoma: A case report

Liang

Wang²,

Sun³

et al. 2023

Front. Neurol.

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BackgroundParaneoplastic peripheral neuropathy (PPN) caused by olfactory neuroblastoma (ONB) has not yet been reported.Case reportWe present a rare case of an adult who hospitalized repeatedly over the past 9 months for persistent pain and numbness in the limbs. This patient was initially diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP) and treated accordingly, but neurological symptoms did not improve significantly. After this admission, FDG-PET/CT showed focal hypermetabolism of a soft-tissue mass in the nasal cavity, and further lesion biopsy suggested ONB. Combined with positive serum anti-Hu antibody, the diagnosis of PPN associated with ONB was eventually made. Furthermore, the patient's neurological symptoms were relieved after removal of the primary tumor, confirming the accuracy of the diagnosis.ConclusionOur case not only expanded the clinical characteristics of ONB but also highlighted the importance of early and comprehensive tumor screening for the diagnosis of PPN.

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Section: Discussionmentioning

confidence: 99%

Persistent pain and numbness in the extremities of an adult due to paraneoplastic peripheral neuropathy caused by olfactory neuroblastoma: A case report

Liang

Wang²,

Sun³

et al. 2023

Front. Neurol.

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“…Cystic degeneration and bleeding have also been reported. Enhanced T1WI displays more than moderate and inhomogeneous enhancement[ 10 ]; and (3) Approximately 20% of schwannomas occur in the anterior skull base. In most cases, T2WI findings indicate a hyperintense signal with variable enhancement[ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Supratentorial hemangioblastoma at the anterior skull base: A case report

Xu¹,

Cao²,

Yin³

et al. 2022

WJCC

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BACKGROUND Hemangioblastoma (HB) is a rare tumor, comprising about 2% of all intracranial tumors. Although it is a benign tumor, due to the abundant blood supply and its close relationship with adjacent cerebral blood vessels, surgical resection is difficult and may cause complications such as bleeding. If HB can be correctly diagnosed before surgery, complications can be avoided by methods such as vascular embolism before surgery. CASE SUMMARY A 51-year-old male patient was admitted to our hospital because of blurred vision in his left eye for 2 years. Ophthalmological examination revealed oculus dexter vision acuity of 1.0 and oculus sinister vision acuity of 0.6. His left vision had tubular visual field, while his right vision had a partial defect. Computed tomography and magnetic resonance imaging showed a mass lesion at the left anterior base of the skull, which could have been a meningioma. During the operation, the tumor was found to be located at the entrance of the left optic nerve tube, closely adhering to the left optic nerve and the blood supply was extremely abundant. The tumor was carefully separated and diagnosed as HB postoperatively after pathological examination. CONCLUSION A rare HB at the anterior skull base could be distinguished by its imaging features, which is essential to the surgical procedures.

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“…Olfactory neuroblastoma or esthesioneuroblastoma develops in the olfactory cleft. Treatment is multimodal, including surgery in combination with postoperative RT [ 63 – 67 ]. For high-grade olfactory neuroblastoma (Hyams 3–4), induction ChT could be considered, followed by ChRT in case of good response [ 68 ].…”

Section: Surgical Strategy According To Histologymentioning

confidence: 99%

The Selective Role of Open and Endoscopic Approaches for Sinonasal Malignant Tumours

López

Shah

Beitler³

et al. 2022

Adv Ther

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Endoscopic endonasal surgery has been demonstrated to be effective in the treatment of selected cases of sinonasal cancers. However, in cases of locally advanced neoplasms, as well as recurrences, the most appropriate approach is still debated. The present review aims to summarize the current state of knowledge on the utility of open approaches to resect sinonasal malignant tumours. Published comparative studies and meta-analyses suggest comparable oncological results with lower morbidity for the endoscopic approaches, but selection biases cannot be excluded. After a critical analysis of the available literature, it can be concluded that endoscopic surgery for selected lesions allows for oncologically safe resections with decreased morbidity. However, when endoscopic endonasal surgery is contraindicated and definitive chemoradiotherapy is not appropriate, craniofacial and transfacial approaches remain the best therapeutic option.

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Olfactory Neuroblastoma

Cited by 9 publications

References 0 publications

Persistent pain and numbness in the extremities of an adult due to paraneoplastic peripheral neuropathy caused by olfactory neuroblastoma: A case report

Persistent pain and numbness in the extremities of an adult due to paraneoplastic peripheral neuropathy caused by olfactory neuroblastoma: A case report

Supratentorial hemangioblastoma at the anterior skull base: A case report

The Selective Role of Open and Endoscopic Approaches for Sinonasal Malignant Tumours

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