Olfactory neuroblastoma (esthesioneuroepithelioma) of the maxillary sinus

Mashberg, Arthur; Thoma, Kurt H.; Wasilewski, Edward

doi:10.1016/0030-4220(60)90032-3

Cited by 27 publications

(12 citation statements)

References 2 publications

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“…A review of the literature reveals 14 previously described cases of ectopic ONB arising from the following anatomical locations: six in the sphenoid sinus, five in the sellar region and one each in the lateral nasal wall, the petrous apex, the pituitary gland, the maxillary sinus and the nasopharynx [3][4][5][6][7]. In this paper, we present four case reports of ONB arising from the following ectopic locations; the anterior ethmoids, the sphenoid sinus, the nasopharynx and the floor of the nose.…”

Section: Discussionmentioning

confidence: 99%

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Ectopic olfactory neuroblastoma: report of four cases and a review of the literature

Wormald

Lennon

O'Dwyer

2010

Eur Arch Otorhinolaryngol

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Our objective is to present a short series of four rare cases of ectopic olfactory neuroblastoma. Our methods present four case reports of ectopic olfactory neuroblastoma and a review of the literature for management and treatment of this disease. The results indicate short case series reports of ectopic olfactory neuroblastoma arising from the anterior ethmoidal sinuses, the nasopharynx, the lateral nasal wall and the floor of the nose. The discussion focuses on likely origins of ectopic olfactory neuroblastoma, its clinical features and management. We conclude that ectopic olfactory neuroblastoma is a rare disease. Treatment principles are the same for non-ectopic disease and guided by extension into adjacent structures such as the orbit or anterior cranial fossa and usually involves surgery with or without adjuvant radiotherapy.

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Section: Discussionmentioning

confidence: 99%

“…The development of ONB outside this region, where olfactory neuroepithelium does not normally exist, is extremely rare. Ectopic ONB has been rarely reported in the literature from regions such as the maxillary sinus, the sphenoid sinus, the petrous apex, atypical locations in the nasal cavity and the pituitary gland [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 97%

Ectopic olfactory neuroblastoma: report of four cases and a review of the literature

Wormald

Lennon

O'Dwyer

2010

Eur Arch Otorhinolaryngol

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“…Therefore, ENB is most commonly seen in the superior nasal vault. Ectopic ENBs are extremely rare but have been previously reported arising in the maxillary sinus, sphenoid sinus, pituitary gland, lateral nasal wall, nasopharynx, and parapharyngeal space …”

Section: Discussionmentioning

confidence: 99%

Possible esthesioneuroblastoma metastasis to paranasal sinuses: Clinical report and literature review

et al. 2015

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“…Although the disease typically develops in these locations, an ectopic origin within the lower nasal cavity and paranasal sinuses, as seen in this patient, has been reported. 7,8 Histologically, in most cases, there are morphologic features of neuroblastoma, with a fibrillary cytoplasmic background of neuronal-cell processes and sometimes rosettes of the Homer Wright or Flexner-Wintersteiner type. 9 Olfactory neuroblastomas lack the t(11:22) translocation that is characteristic of Ewing's sarcoma 10,11 and are genetically heterogeneous, distinct from conventional neuroblastoma, but with some overlapping genetic features.…”

Section: Pathol O Gic a L Discussionmentioning

confidence: 99%

Case 20-2007

Cunningham

Lin²,

Curry³

et al. 2007

N Engl J Med

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Pr e sen tat ion of C a seDr. Margo McKenna Benoit (Otolaryngology): An 11-year-old boy was referred to a pediatric otolaryngologist at the Massachusetts Eye and Ear Infirmary because of headaches and a right nasal mass. Bifrontal headaches had started approximately 5 years earlier; in recent months, the pain had been predominantly in the right supraorbital area. The patient had chronic nasal congestion with occasional rhinorrhea. Approximately 2 years earlier, a neurologist had made a diagnosis of migraine headache. Magnetic resonance imaging (MRI) of the head at that time showed no intracranial abnormalities, but the findings were interpreted as being consistent with sinusitis.Two months before presentation, the headaches became more frequent and severe. Plain radiographs of the sinuses obtained at another hospital showed a lesion with the density of bone in the right ethmoid region. The patient was referred to an otolaryngologist, who noted a reddish soft-tissue mass within the right nasal cavity. Endoscopic examination confirmed that the mass arose laterally to the right middle turbinate. The left nasal cavity was normal. Cranial-nerve function was intact. There was no palpable cervical lymphadenopathy. The remainder of the examination was normal. Computed tomography (CT) of the paranasal sinuses 10 days later revealed a heavily calcified mass centered in and expanding the right ethmoid sinus; there was complete opacification of the ipsilateral maxillary, anterior ethmoid, and frontal sinuses. The lesion contacted the roof of the ethmoid sinus but did not involve the upper nasal cavity or cribriform plate. There were no pathologically enlarged lymph nodes. The patient was referred to this hospital.He had no weight gain or loss, malaise, fatigue, fever, chills, anosmia, epistaxis, or visual symptoms. Several years earlier, he had sustained a traumatic right orbital fracture as a result of a baseball injury. He had also had a right femoral fracture requiring operative reduction and had undergone adenotonsillectomy for obstructive indications. His only medication was ibuprofen for headaches. He had no known drug allergies. There was a maternal history of migraine headache. He was a sixth grader in the public school system and had recently received a diagnosis of a learning disability. He had not traveled recently and had no known exposure to infectious diseases.

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Olfactory neuroblastoma (esthesioneuroepithelioma) of the maxillary sinus

Cited by 27 publications

References 2 publications

Ectopic olfactory neuroblastoma: report of four cases and a review of the literature

Ectopic olfactory neuroblastoma: report of four cases and a review of the literature

Possible esthesioneuroblastoma metastasis to paranasal sinuses: Clinical report and literature review

Case 20-2007

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