Olfactory modulation of the medial prefrontal cortex circuitry: Implications for social cognition

Bhattarai, Janardhan P.; Etyemez, Semra; Jaaro-Peled, Hanna; Janke, Emma; Tolosa, Usuy D. Leon; Kamiya, Atsushi; Gottfried, Jay A.; Sawa, Akira; Ma, Minghong

doi:10.1016/j.semcdb.2021.03.022

Cited by 30 publications

(18 citation statements)

References 159 publications

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“…Considering the prevalence of value and non-value meaning coding we observed in AON, DP, and TTd, perhaps these regions are a crucial first step in processing and amplifying task-related input from the olfactory bulb. Because they provide input to PFC (Bhattarai et al, 2021;Igarashi et al, 2012), they may be an important source of the odor coding we observed there. Our findings in AON, DP, and TTd differ from reports that piriform cortex lacks odor value representations (Blazing and Franks, 2020;Wang et al, 2020a;Winkelmeier et al, 2022) and suggest that these olfactory peduncular areas, as well as olfactory tubercle (Gadziola et al, 2015;Millman and Murthy, 2020;Winkelmeier et al, 2022), may provide more value-related processing of odor cues than better-studied odor processing routes through piriform cortex (Blazing and Franks, 2020;Mori and Sakano, 2021;Winkelmeier et al, 2022).…”

Section: Widespread Value Signalingmentioning

confidence: 96%

“…Considering the prevalence of value and non-value trial type coding we observed in AON, DP, and TTd, perhaps these regions are a crucial first step in processing and amplifying task-related input from the olfactory bulb. Because they provide input to PFC (Bhattarai et al, 2021;Igarashi et al, 2012), they may be an important source of the odor coding we observed there. Previous recordings in AON, DP, and TTd were in anesthetized rodents (Cousens, 2020;Kikuta et al, 2008;Lei et al, 2006;Tsuji et al, 2019); as the first recordings in awake behaving animals, our results bring these regions into focus for future work on the transformation of odor information into task-relevant coding.…”

Section: Widespread Value Signalingmentioning

confidence: 96%

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A stable, distributed code for cue value in mouse cortex during reward learning

Ottenheimer

Hjort

Bowen³

et al. 2022

Preprint

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The ability to associate reward-predicting stimuli with adaptive behavior is frequently attributed to the prefrontal cortex, but the stimulus-specificity, spatial distribution, and stability of neural cue-reward associations are unresolved. We trained headfixed mice on an olfactory Pavlovian conditioning task and measured the coding properties of individual neurons across space (prefrontal, olfactory, and motor cortices) and time (multiple days). Neurons encoding cues and licks were most common in olfactory and motor cortex, respectively. By classifying cue-encoding neurons according to their responses to the six odor cues, we unexpectedly found value coding, including coding of trial-by-trial reward history, in all regions we sampled. We further found that prefrontal cue and lick codes were preserved across days. Our results demonstrate that individual prefrontal neurons stably encode components of cue-reward learning within a larger spatial gradient of coding properties.

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Section: Widespread Value Signalingmentioning

confidence: 96%

Section: Widespread Value Signalingmentioning

confidence: 96%

A stable, distributed code for cue value in mouse cortex during reward learning

Ottenheimer

Hjort

Bowen³

et al. 2022

Preprint

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“…Recent evidences have highlighted the role, hitherto underestimated, of the olfactory pathway in the regulation of higher brain functions and its involvement in the pathophysiology of psychiatric disorders. In this sense, an overlap has been described between the neural connections of the olfactory system, temporo-limbic and frontal functions that are associated with higher brain functions such as cognition, memory and emotion, which are the ones that are altered in psychiatric disorders [ 1 ••, 7 ]. Accordingly, it is currently considered that alterations of the peripheral and central olfactory system contribute to an altered emotional process of olfactory stimulation in patients with psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Olfactory Dysfunction in Mental Illness

Marı́n

Alobid

Fuentes

et al. 2023

Curr Allergy Asthma Rep

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Purpose of Review Olfactory dysfunction contributes to the psychopathology of mental illness. In this review, we describe the neurobiology of olfaction, and the most common olfactory alterations in several mental illnesses. We also highlight the role, hitherto underestimated, that the olfactory pathways play in the regulation of higher brain functions and its involvement in the pathophysiology of psychiatric disorders, as well as the effect of inflammation on neurogenesis as a possible mechanism involved in olfactory dysfunction in psychiatric conditions. Recent Findings The olfactory deficits present in anxiety, depression, schizophrenia or bipolar disorder consist of specific alterations of different components of the sense of smell, mainly the identification of odours, as well as the qualifications of their hedonic valence (pleasant or unpleasant). Epidemiological findings have shown that both environmental factors, such as air pollutants, and inflammatory disease of the upper respiratory tract, can contribute to an increased risk of mental illness, at least in part, due to peripheral inflammatory mechanisms of the olfactory system. Summary In this review, we describe the neurobiology of olfaction, and the most common olfactory function alterations in several psychiatric conditions and its role as a useful symptom for the differential diagnosis. We also highlight the effect of inflammation on neurogenesis as a possible mechanism involved in olfactory dysfunction in these psychiatric conditions.

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“…These nuclei also support the diencephalic homeostatic networks, which include the lateral habenula (that modulates the VTA), the mammillary bodies, the hypothalamic paraventricular nucleus, the supraoptic and supra-mammillary nuclei. They also are relevant in memory networks with high expression in hippocampal astrocytes and CA1 and CA 2 cell layers and in the olfactory bulb, which through the uncinate fasciculus will have modulatory effects on the mPFC especially the ACC and its emotion regulation roles 21 22 .…”

Section: Introductionmentioning

confidence: 99%