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Toxicology must deal with a large variety of atmospheric contaminants possessing a vast array of toxic effects. Such contaminants include gases and vapors, which may be asphyxiants, irritants, metabolic poisons or carcinogens, and aerosols in the form of dusts, fumes, smokes, mists, fogs, andsmogs. The respiratory system is an efficient route of entry for such substances. The pervasive presence of atmospheric pollutants behooves us to examine the effects of representative agents that pose environmental or occupational hazards. This paper will discuss techniques suitable for characterizing the behavioral significance of airborne contaminants as stimulus events that can control behavior. It will not emphasize their role in the toxicologic impairment of behavior. Techniques used to evaluate poisons administered by other routes generally can be used to evaluate the behavioral effects of inhaled substances.Studies of the behavioral effects and stimulus properties of inhaled agents require the investigator to master both the behavioral technology and the instrumental techniques for generating and monitoring test atmospheres. Perhaps this need for a dual apprenticeship explains the relative paucity of experimental work in this area. Fortunately, a number of good reference works are available (1-4). When studying the stimulus properties of inhaled