Olfactory ganglioneuroblastoma in a dog: case report and literature review

Abstract

A 7-y-old, intact male Alaskan Malamute was presented with a 3-mo history of stertor and epistaxis. Computed tomography of the skull revealed generalized loss of gas throughout both nasal passages with replacement by a soft tissue mass that traversed the cribriform plate. Histopathology revealed neoplastic neuroblast cells arranged in anastomosing cords, as well as separately located aggregates of ganglion cells. Both neoplastic cell populations demonstrated immunoreactivity to MAP-2, TuJ-1, and synaptophysin. Neuroblastic cells additionally exhibited punctate immunoreactivity to MCK and CK8/18. We document here both the positive neural immunohistochemical markers for this neoplasm, as well as propose possible histomorphologic variants.

MRI and CT characteristics of a grade I meningioma with concurrent cribriform plate lysis in a dog

“…9 Olfactory neuroblastomas are also known to invade the cribriform plate, cranial vault and brain, but these are considered to be rare tumors in dogs. 10 This imaging finding can help clinicians rank differential diagnoses; however, this report outlines the possibility of meningiomas also being concurrent with such osteolytic changes.…”