Olfactory functions in patients with psoriasis vulgaris: correlations with the severity of the disease

Aydın, Ersin; Tekelı, Hakan; Karabacak, Ercan; Altunay, İlknur Kıvanç; Aydın, Çiğdem; Çerman, Aslı Aksu; Altundağ, Aytuğ; Salihoğlu, Murat; Çayönü, Melih

doi:10.1007/s00403-016-1662-7

Cited by 14 publications

(14 citation statements)

References 30 publications

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“…In the present study 50% of patients with postinfectious olfactory loss showed ANAs. These results suggest that postinfectious smell loss might be related to immune mediated processes as reduced olfactory function has been already shown in several autoimmune meditaed diseases such as multiple sclerosis (27) , pemphigus vulgaris (10) , psoriasis vulgaris (11) and Sjögren syndrome (12) .…”

Section: Discussionsupporting

confidence: 58%

“…In several autoimmune diseases (8) decreased olfactory function has been shown, e.g. systemic lupus erythematosus (9) , pemphigus vulgaris (10) , psoriasis vulgaris (11) , Sjögren syndrome (12) and Wegener's disease (13,14) . In addition, reduced olfactory function has been shown in several other diseases, which are discussed to be mediated by autoimmune processes, e.g.…”

Section: Neurological Disorders and Autoimmune Processes Have Beenmentioning

confidence: 99%

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Antinuclear antibodies in postinfectious smell loss - a pilot study

Walliczek-Dworschak¹,

Zimmermann²,

Poletti³

et al. 2019

RHINOL

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Background: Numerous diseases are mediated by autoimmune mechanisms some of which have been shown to be associated with reduced olfactory function, e.g. systemic lupus erythematosus, Sjögren syndrome, psoriasis vulgaris. Postinfectious smell loss is a frequent cause of olfactory dysfunction. However, its nature is not fully understood, but connections to immune mediated processes might be possible. The primary aim of the present study was therefore to investigate the possible relation of postinfectious smell loss with autoimmune processes. Methods: Fifty-two patients (35 female, 17 male; mean age 57 years ± 12 years) with postinfectious smell loss and 56 controls (21 female, 35 male; mean age 58 years ± 13 years), with olfactory dysfunction of other causes (sinunasal, posttraumatic or idiopathic)were included in the present study. The patients' olfactory function was measured using the extended test battery of the "Sniffin' Sticks". Furthermore venous blood samples were taken and analyzed for antinuclear autoantibodies. Results:Patients showed anti-nuclear antibodies (ANA) significantly more frequently compared to controls, although ANAs were typically only present at cut off levels of 1:100. In addition, there was a significant association between the presence of ANAs and odor thresholds. Conclusions:Results from this study indicate that postinfectious olfactory dysfunction may be associated with autoimmune processes, as they show significantly more ANAs -although not at a clincially significant level -compared to patients with olfactory deficits of other origin.

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Section: Discussionsupporting

confidence: 58%

Section: Neurological Disorders and Autoimmune Processes Have Beenmentioning

confidence: 99%

Antinuclear antibodies in postinfectious smell loss - a pilot study

Walliczek-Dworschak¹,

Zimmermann²,

Poletti³

et al. 2019

RHINOL

View full text Add to dashboard Cite

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“…(Ahn et al, 2016). In addition, Aydın et al (2016) found that the olfactory function of patients with psoriasis was significantly worse than that of healthy controls (P < 0.001). These results suggest that m 6 A methylation may be involved in the mechanism of anosmia in psoriasis vulgaris.…”

Section: Discussionmentioning

confidence: 96%

“…Olfactory receptors are known to be expressed not only in nasal tissue but also in skin tissue and specifically in keratinocytes, dendritic cells, and melanocytes ( Ahn et al, 2016 ). In addition, Aydın et al (2016) found that the olfactory function of patients with psoriasis was significantly worse than that of healthy controls ( P < 0.001). These results suggest that m 6 A methylation may be involved in the mechanism of anosmia in psoriasis vulgaris.…”

Section: Discussionmentioning

confidence: 98%

“…In addition to these shared pathways, DMRs in the PP vs. NN and PP vs. PN comparisons were also associated with some specific pathways. For example, in PP vs. NN, hypermethylated DMRs in PP were specifically associated with olfactory transduction (Figure 2D and Supplementary Data 4), which may explain why psoriasis patients have an abnormal sense of smell (Aydın et al, 2016); meanwhile, hypomethylated DMRs in PP were specifically associated with the MAPK signaling pathway (Figure 2E and Supplementary Data 4), which is involved in almost every aspect of psoriasis vulgaris, including keratinocyte proliferation, differentiation, migration, T-helper-cell differentiation, and angiogenesis (Mavropoulos et al, 2013). In the PP vs. PN comparison, DMRs were specifically associated with the cell cycle and gap junction (Supplementary Figures 5E,F and Supplementary Data 4).…”

Section: Kyoto Encyclopedia Of Genes and Genomes Pathway Analysis Of mentioning

confidence: 99%

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Transcriptome-Wide m6A Methylation in Skin Lesions From Patients With Psoriasis Vulgaris

Wang

Jin

2020

Front. Cell Dev. Biol.

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N 6-methyladenosine (m 6 A) methylation, as the most prevalent internal RNA modification, has been revealed to play critical roles in various biological functions. In this study, we performed m 6 A transcriptome-wide profiling in three kinds of skin tissue: involved psoriatic skin (PP), uninvolved psoriatic skin (PN), and healthy control skin samples (NN). The findings revealed that transcripts of PP contained the fewest m 6 A peaks and lowest m 6 A peak density. The greatest differences of m 6 A methylation were observed in the PP vs. NN and PP vs. PN comparisons. Intriguingly, in these comparisons, hypermethylated m 6 A was mainly enriched within the CDSs and 3 UTRs, while hypomethylated m 6 A was not only enriched within CDSs and 3 UTRs, but also within 5 UTRs. GO and KEGG pathway analyses indicated that hypermethylated transcripts in PP were particularly associated with response-associated terms, cytokine production, and olfactory transduction. Meanwhile, hypomethylated transcripts in PP were mainly associated with development-related processes and the Wnt signaling pathway. In addition, we discovered that 19.3-48.4% of the differentially expressed transcripts in psoriasis vulgaris were modified by m 6 A, and that transcripts with lower expression were more preferentially modified by m 6 A. Moreover, upregulation of gene expression was often accompanied by upregulation of m 6 A methylation, suggesting a regulatory role of m 6 A in psoriasis vulgaris gene expression.

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Association of Olfactory Impairment With All-Cause Mortality

Pang

Song

Tan

et al. 2022

JAMA Otolaryngol Head Neck Surg

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IMPORTANCE Olfactory impairment is highly prevalent and associated with multiple comorbidities, including neurodegenerative, cardiovascular, nutritional, and immune disorders. However, epidemiologic associations between olfactory impairment and mortality are discordant.OBJECTIVE To systematically clarify the epidemiologic associations between olfactory impairment and mortality.DATA SOURCES The PubMed, Embase, and Cochrane Library databases were searched from inception to August 13, 2021.STUDY SELECTION Two blinded reviewers selected observational studies published as full-length, English-language articles in peer-reviewed journals that reported the presence or severity of chronic olfactory impairment, whether objectively measured or self-reported, in association with any mortality estimate, among adults aged 18 years or older.DATA EXTRACTION AND SYNTHESIS Two reviewers independently extracted data, evaluated study bias using the Newcastle-Ottawa Scale, and appraised the quality of the evidence using the Grading of Recommendations Assessment, Development and Evaluation framework, following Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) and Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines and a PROSPERO-registered protocol. Maximally adjusted estimates were pooled using mixed-effects models, heterogeneity was measured using I 2 statistics, sources of heterogeneity were investigated using meta-regression and subgroup meta-analyses, and publication bias was qualitatively and quantitatively assessed. MAIN OUTCOMES AND MEASURESHazard ratios for all-cause mortality. RESULTSOne retrospective cohort study and 10 prospective cohort studies (with a total of 21 601 participants) from 1088 nonduplicated records were included. Ten studies had a low risk of bias, whereas 1 study had a moderate risk; exclusion of the latter did not alter conclusions. Nine studies were included in the meta-analysis. Olfactory loss was associated with a significantly higher pooled hazard of all-cause mortality (hazard ratio, 1.52; 95% CI, 1.28-1.80; I 2 = 82%). Meta-regression sufficiently explained heterogeneity, with longer mean follow-up duration weakening the pooled association, accounting for 91.3% of heterogeneity. Self-reported and objective effect sizes were similar. Associations were robust to trim-and-fill adjustment and the Egger test for publication bias. The overall quality of evidence was moderate. CONCLUSIONS AND RELEVANCEThe findings of this systematic review and meta-analysis suggest that olfactory impairment is associated with all-cause mortality and may be a marker of general health and biological aging. Further research is required to establish the underlying mechanisms and the scope for interventions.

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Olfactory functions in patients with psoriasis vulgaris: correlations with the severity of the disease

Cited by 14 publications

References 30 publications

Antinuclear antibodies in postinfectious smell loss - a pilot study

Antinuclear antibodies in postinfectious smell loss - a pilot study

Transcriptome-Wide m6A Methylation in Skin Lesions From Patients With Psoriasis Vulgaris

Association of Olfactory Impairment With All-Cause Mortality

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