Olfactory function in patients with and without temporal lobe resection

Haehner, Antje; Henkel, Sophia; Hopp, Peter; Hallmeyer-Elgner, Susanne; Reuner, Ulrike; Reichmann, Heinz; Hummel, Thomas

doi:10.1016/j.yebeh.2012.09.011

Cited by 20 publications

(25 citation statements)

References 20 publications

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“…Our finding that TLE produces bilateral deficits in odor identification and discrimination is in accord with a number of earlier, less definitive, studies [1, 5, 19, 21, 29, 30, 32]. However, our findings differ from studies reporting no effects of TLE on odor identification [27] or memory [19], as well as a study noting discrimination deficits only in patients with right-side foci [1].…”

Section: Discussionsupporting

confidence: 89%

“…Importantly, our findings that both TLE and TLR negatively impact odor detection thresholds differ from reports of no threshold deficits in TLE patients [1, 19, 32] or TLR patients. [17–19, 21, 24, 29, 49]. While our data are in accord with those of three studies noting threshold deficits in TLR patients [32, 38, 39], two of these studies evaluated olfactory function bilaterally and had no TLE control group, confounding TLR with TLE [38, 39].…”

Section: Discussionsupporting

confidence: 87%

“…Results from threshold studies have been variable. Thus, in the case of TLE, some have reported lowered olfactory thresholds (i.e., enhanced sensitivity; [4, 8, 24, 41, 46]), whereas others have seen no such effects [7, 18, 19, 21, 29, 32, 43, 49] or have seen elevated thresholds [26]. In the case of TLR, one study found bilaterally elevated detection and recognition thresholds (i.e., lessened sensitivity) following either left or right TLR [39], whereas another found elevated recognition, but not detection, thresholds [22].…”

Section: Introductionmentioning

confidence: 99%

“…In the case of TLR, one study found bilaterally elevated detection and recognition thresholds (i.e., lessened sensitivity) following either left or right TLR [39], whereas another found elevated recognition, but not detection, thresholds [22]. Although most studies have reported no influences of TLR on odor detection thresholds, brief tests of questionable sensitivity have been commonly employed [18, 19, 21, 22, 29]. The sole study to compare olfactory thresholds pre- and post-operatively in the same subjects found n -butanol thresholds to be unaffected by left-side resection in their 10 left-side epilepsy patients; their 11 right-side TLR patients exhibited elevated thresholds on the right side of the nose [32].…”

Section: Introductionmentioning

confidence: 99%

“…In seeming accord with the findings of Abraham and Mathai [1], Rausch et al [40] found larger right-side than left-side TLR influences on an odor discrimination/memory task. More recently, Jones-Gotman et al [30] and Haehner et al [21] found poorer bilateral odor identification in TLR patients, with poorest performance on the resected side. Other investigators have found no differences between left- and right-side foci and/or resections on bilaterally-administered olfactory tests, including tests of identification, odor memory, and discrimination [9, 18, 19, 27, 29, 42, 49].…”

Section: Introductionmentioning

confidence: 99%

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Influences of temporal lobe epilepsy and temporal lobe resection on olfaction

et al. 2018

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Although temporal lobe epilepsy (TLE) and resection (TLR) impact olfactory eloquent brain structures, their influences on olfaction remain enigmatic. We sought to more definitively assess the influences of TLE and TLR on olfaction using three well-validated olfactory tests and measuring the tests' associations with the volume of numerous temporal lobe brain structures. The University of Pennsylvania Smell Identification Test and an odor detection threshold test were administered to 71 TLE patients and 71 age- and sex-matched controls; 69 TLE patients and controls received an odor discrimination/memory test. Fifty-seven patients and 57 controls were tested on odor identification and threshold before and after TLR; 27 patients and 27 controls were similarly tested for odor detection/discrimination. Scores were compared using analysis of variance and correlated with pre- and post-operative volumes of the target brain structures. TLE was associated with bilateral deficits in all test measures. TLR further decreased function on the side ipsilateral to resection. The hippocampus and other structures were smaller on the focus side of the TLE subjects. Although post-operative volumetric decreases were evident in most measured brain structures, modest contralateral volumetric increases were observed in some cases. No meaningful correlations were evident pre- or post-operatively between the olfactory test scores and the structural volumes. In conclusion, we demonstrate that smell dysfunction is clearly a key element of both TLE and TLR, impacting odor identification, detection, and discrimination/memory. Whether our novel finding of significant post-operative increases in the volume of brain structures contralateral to the resection side reflects plasticity and compensatory processes requires further study.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Influences of temporal lobe epilepsy and temporal lobe resection on olfaction

et al. 2018

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Odor Perception and Neuropathology in Neurodegenerative Diseases and Schizophrenia

Doty

Hawkes

Good

et al. 2015

Handbook of Olfaction and Gustation

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International consensus statement on allergy and rhinology: Olfaction

Patel

Holbrook

Turner

et al. 2022

Int Forum Allergy Rhinol

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Background:The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O). Methods: Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus. Results:The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies. Conclusion:This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.

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Olfactory function in patients with and without temporal lobe resection

Cited by 20 publications

References 20 publications

Influences of temporal lobe epilepsy and temporal lobe resection on olfaction

Influences of temporal lobe epilepsy and temporal lobe resection on olfaction

Odor Perception and Neuropathology in Neurodegenerative Diseases and Schizophrenia

International consensus statement on allergy and rhinology: Olfaction

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