Olfactory Function Following Nasal Surgery

Pade, Jürgen; Hummel, Thomas

doi:10.1097/mlg.0b013e318170b5cb

Cited by 135 publications

(200 citation statements)

References 23 publications

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“…In our series we achieved 77% improvement, comparable to other reports [11,12,14]. Considering the 68.5% prevalence of nasal polyposis with worse prognosis, this is an acceptable level of improvement.…”

Section: Discussionsupporting

confidence: 78%

“…This method can reduce damage to olfactory function during the endoscopic surgery. History of smoking and polyp pathology had a more negative effect on final outcome than other causes, similar to other studies [9,14,17,18].…”

Section: Discussionsupporting

confidence: 77%

“…Our study, as in some previous series, found that age, sex and previous surgery had no relation with postoperative smell improvement as determined by objective evaluation of the ability to smell [14]. However, in our series we found a significant relationship between subjective postoperative smell test results and age.…”

Section: Discussioncontrasting

confidence: 47%

“…In spite of these obstacles to proper smell function, there are various reports claiming improvement varying between 50 and 100% after surgery [3,8,[13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…Few studies on the outcome of endoscopic sinus surgery have dealt with the effect of surgery on the sense of smell and they found contrasting results [7,8,13,14]. Additionally, nature, frequency and associated factors of this disorder are unclear.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of FESS in Smell Improvement of Sinusitis Patients

Saedi

Sadeghi

Yazdani

et al. 2012

Indian J Otolaryngol Head Neck Surg

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The aim of this research was to verify the effect of functional endoscopic sinus surgery (FESS) on olfactory dysfunction in patients who suffer from chronic rhinosinusitis. We enrolled prospective consecutive patients at a tertiary institution who were undergoing FESS; for these patients prolonged medical therapy for chronic rhinosinusitis had failed. Patients were asked to grade their olfactory dysfunction from 1 to 5 with 1 representing lack of any smell function and 5 representing a completely normal sense of smell. Moreover, the pre-and postoperative smell identification test of the University of Pennsylvania was performed for all participating patients. In addition, data including computed tomography scores, nasal endoscopy, and the presence or absence of asthma as well as smoking habits were recorded and analyzed. Patients were followed at least 1 year after surgery. Data were collected on 89 patients who had undergone sinus surgery. Postoperative olfactory function was 77% improved for all subjects as a group. Higher involvement of sinus in computed tomography correlated with poorer results in olfactory UPSIT40 score. Patients' olfaction was significantly related to polyp pathology, duration of disease, age, smoking habits and history of asthma. A variety of patients' characteristics have impact on olfactory outcome of sinusitis patients after FESS.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 77%

Section: Discussioncontrasting

confidence: 47%

“…In spite of these obstacles to proper smell function, there are various reports claiming improvement varying between 50 and 100% after surgery [3,8,[13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effectiveness of FESS in Smell Improvement of Sinusitis Patients

Saedi

Sadeghi

Yazdani

et al. 2012

Indian J Otolaryngol Head Neck Surg

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Clinical Disorders of Olfaction

Doty

2015

Handbook of Olfaction and Gustation

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Comparative effectiveness of medical and surgical therapy on olfaction in chronic rhinosinusitis: a prospective, multi‐institutional study

DeConde

Mace

Alt

et al. 2014

Int Forum Allergy Rhinol

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Background Evidence comparing the impact of medical and surgical management of chronic rhinosinusitis on olfactory function is limited. This study evaluates olfactory outcomes in patients who failed initial medical management and elect either continued medical management or endoscopic sinus surgery (ESS) followed by medical management. Methods Adult subjects were prospectively enrolled into a non-randomized, multi-institutional cohort. Baseline characteristics, quality-of-life and objective clinical findings were collected along with two quality-of-life disease-specific measures, the Rhinosinusitis Disability Index (RSDI) and Sinonasal Outcome Test (SNOT-22). The primary outcome measure was the post-treatment change (≥6 months) in the Brief Smell Identification Test (B-SIT). Bivariate and multivariate analyses compared B-SIT changes by treatment type while controlling for baseline cofactors. Results Subjects (n=280) were enrolled between March, 2011 and May, 2013. Baseline B-SIT scores were comparable between medical and surgical treatment groups (8.8(3.2) vs 9.0(3.2); p=0.703). Subjects with baseline impaired olfaction (n=83; 29.6%) experienced mean B-SIT improvement in both the medical (n=17, 2.3(2.8), p=0.005) and surgical (n=66, 2.1(3.0), p<0.001) cohort. 38.6% of subjects with impaired olfaction return to normal olfaction at follow-up with no difference identified between treatment modalities (p=0.803). Multivariate analyses identified prior surgery as a predictor of less improvement regardless of treatment modality in patients with baseline impaired olfaction. Average changes in B-SIT scores were comparable between treatment groups (p>0.050). Conclusion Subjects electing ESS experienced gains in olfaction comparable to subjects electing continued medical management. Further study with larger sample size and more sensitive measures of olfaction are needed to determine differences between treatment groups.

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Olfactory Function Following Nasal Surgery

Cited by 135 publications

References 23 publications

Effectiveness of FESS in Smell Improvement of Sinusitis Patients

Effectiveness of FESS in Smell Improvement of Sinusitis Patients

Clinical Disorders of Olfaction

Comparative effectiveness of medical and surgical therapy on olfaction in chronic rhinosinusitis: a prospective, multi‐institutional study

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