Olfactory ensheathing cells promote nerve regeneration and functional recovery after facial nerve defects

Gu, Jian; Xu, He N.; Xu, Yuping; Liu, Huanhai; Lang, Juntian; Chen, Xiaoping; Xu, Weihua; Deng, Yue; Fan, Jian‐Gao

doi:10.4103/1673-5374.243717

Cited by 20 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In preclinical neuro-histology, a radically novel approach has recently emerged: the so-called tubulation of the nerve trunk using conduits — tubes that serve substrates for nerve repair [ 25 , 26 ]. Under conditions of diastasis, such a substrate can also contain the filler that stimulates nerve regeneration.…”

Section: Introductionmentioning

confidence: 99%

Reconstruction of the Rat Sciatic Nerve by Using Biodegradable and Non-Biodegradable Conduits

Velichanskaya¹,

Абросимов²,

Bugrova³

et al. 2020

Sovrem Tehnol Med

View full text Add to dashboard Cite

The aim of the study was to compare two types of conduits made of either non-resorbable Reperen or resorbable Tissucol for their effects on the regeneration of the rat sciatic nerve under conditions of stump diastasis. Materials and Methods. The experiments were carried out using outbred white male rats of the reproductive age (n=14). The animals were divided into three groups: group 1, intact (n=5), used for studying the morphology of the sciatic nerve; group 2 (n=4) — nerve plastic surgery was performed using a conduit made of non-resorbable Reperen; group 3 (n=5) — surgery was performed using a conduit made of resorbable Tissucol. The animals were anesthetized with isoflurane. After a complete transection of the sciatic nerve in the middle third of the thigh, its stumps were inserted into a conduit of an internal diameter of 2 mm and a length of 10 mm, filled with saline. Diastasis of 5 mm in length was created by spreading the nerve ends and securing the epineurium to the tube edges with 8/0 polypropylene sutures. A total count of myelinated nerve fibers was performed in the area of repair (tubulation) and the distal part of the nerve; the formation of connective tissue sheaths was assessed 14 weeks after the operation. Results. According to the morphological assessment, both types of conduits (resorbable and non-resorbable) caused the similar number of fibers to restore in the distal part of the repaired nerve; clinical characteristics of the animals in both groups were close to each other and to the norm. Conclusion. The results allow us to consider the conduit made of non-resorbable Reperen as a device promising for neuroplasty along with the resorbable conduit made of Tissucol.

show abstract

Section: Introductionmentioning

confidence: 99%

Reconstruction of the Rat Sciatic Nerve by Using Biodegradable and Non-Biodegradable Conduits

Velichanskaya¹,

Абросимов²,

Bugrova³

et al. 2020

Sovrem Tehnol Med

View full text Add to dashboard Cite

show abstract

“…The expression of GFAP and NG2 is down-regulated in the spinal cord segments around the injury, suggesting that there is a more suitable environment for axon regeneration ( López-Vales et al, 2006 ). OECs treatment can increase the number of regenerated neurons, improve the morphology of nerve fibers, increase the number of myelinated nerve fibers, nerve fiber diameter and myelin sheath thickness ( Gu et al, 2019 ). g Another interesting feature is the phagocytic activity of OECs ( Nazareth et al, 2021 ): In the past, it was thought that OECs and astrocytes had some similar characteristics, but later it was further found that OECs and microglia also had common characteristics, which means that OECs have the function of phagocytosis of bacteria ( Vincent et al, 2007 ; Panni et al, 2013 ; Nazareth et al, 2015 ).…”

Section: Biological Characteristics Of Oecsmentioning

confidence: 99%

Section: Biological Characteristics Of Oecsmentioning

confidence: 99%

Olfactory ensheathing cells and neuropathic pain

Liu

Wang

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Damage to the nervous system can lead to functional impairment, including sensory and motor functions. Importantly, neuropathic pain (NPP) can be induced after nerve injury, which seriously affects the quality of life of patients. Therefore, the repair of nerve damage and the treatment of pain are particularly important. However, the current treatment of NPP is very weak, which promotes researchers to find new methods and directions for treatment. Recently, cell transplantation technology has received great attention and has become a hot spot for the treatment of nerve injury and pain. Olfactory ensheathing cells (OECs) are a kind of glial cells with the characteristics of lifelong survival in the nervous system and continuous division and renewal. They also secrete a variety of neurotrophic factors, bridge the fibers at both ends of the injured nerve, change the local injury microenvironment, and promote axon regeneration and other biological functions. Different studies have revealed that the transplantation of OECs can repair damaged nerves and exert analgesic effect. Some progress has been made in the effect of OECs transplantation in inhibiting NPP. Therefore, in this paper, we provided a comprehensive overview of the biology of OECs, described the possible pathogenesis of NPP. Moreover, we discussed on the therapeutic effect of OECs transplantation on central nervous system injury and NPP, and prospected some possible problems of OECs transplantation as pain treatment. To provide some valuable information for the treatment of pain by OECs transplantation in the future.

show abstract

“…Olfactory ensheathing cells have been noted for their ability to facilitate axonal regeneration and have been used in experiments assessing in vivo axonal repair (Li et al, 2003(Li et al, , 2005Gu et al, 2019). Thus, it is possible that these cells would be a good target for direct reprogramming into neurons.…”

Section: Olfactory Ensheathing Cellsmentioning

confidence: 99%

Induced Neurons for Disease Modeling and Repair: A Focus on Non-fibroblastic Cell Sources in Direct Reprogramming

Kim

Thaqi

Peterson

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Direct cellular reprogramming exhibits distinct advantages over reprogramming from an induced pluripotent stem cell intermediate. These include a reduced risk of tumorigenesis and the likely preservation of epigenetic data. In vitro direct reprogramming approaches primarily aim to model the pathophysiological development of neurological disease and identify therapeutic targets, while in vivo direct reprogramming aims to develop treatments for various neurological disorders, including cerebral injury and cancer. In both approaches, there is progress toward developing increased control of subtype-specific production of induced neurons. A majority of research primarily utilizes fibroblasts as the donor cells. However, there are a variety of other somatic cell types that have demonstrated the potential for reprogramming into induced neurons. This review highlights studies that utilize non-fibroblastic cell sources for reprogramming, such as astrocytes, olfactory ensheathing cells, peripheral blood cells, Müller glia, and more. We will examine benefits and obstructions for translation into therapeutics or disease modeling, as well as efficiency of the conversion. A summary of donor cells, induced neuron types, and methods of induction is also provided.

show abstract

Olfactory ensheathing cells promote nerve regeneration and functional recovery after facial nerve defects

Cited by 20 publications

References 33 publications

Reconstruction of the Rat Sciatic Nerve by Using Biodegradable and Non-Biodegradable Conduits

Reconstruction of the Rat Sciatic Nerve by Using Biodegradable and Non-Biodegradable Conduits

Olfactory ensheathing cells and neuropathic pain

Induced Neurons for Disease Modeling and Repair: A Focus on Non-fibroblastic Cell Sources in Direct Reprogramming

Contact Info

Product

Resources

About