Olfactory drug effects approached from human-derived data

Lötsch, Jörn; Knothe, Claudia; Lippmann, Catharina; Ultsch, Alfred; Hummel, Thomas; Walter, Carmen

doi:10.1016/j.drudis.2015.06.012

Cited by 28 publications

(24 citation statements)

References 77 publications

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“…Moreover, some previous studies used non-standardized and not validated olfactory testing14. Additionally, because patients were not matched for well-known factors to affect olfaction13343536 including age, gender and smoking habits121437, those studies must be interpreted with caution38.…”

Section: Discussionmentioning

confidence: 99%

“…Eligible patients had a documented neurosensory hearing loss and RP, fulfilling the clinical criteria for USH1 or USH2, as defined by the USH consortium 2 . Exclusion criteria included participants with known factors affecting olfaction, such as post-traumatic olfactory dysfunction, sinonasal disease, malignant tumor, recent radiotherapy or chemotherapy, post-upper respiratory tract infection, use medication known to interfere in olfaction 32 , and Parkinson´s and Alzheimer´s disease.…”

Section: Methodsmentioning

confidence: 99%

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Accelerated age-related olfactory decline among type 1 Usher patients

Ribeiro

Oliveiros

Pereira

et al. 2016

Sci Rep

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Usher Syndrome (USH) is a rare disease with hearing loss, retinitis pigmentosa and, sometimes, vestibular dysfunction. A phenotype heterogeneity is reported. Recent evidence indicates that USH is likely to belong to an emerging class of sensory ciliopathies. Olfaction has recently been implicated in ciliopathies, but the scarce literature about olfaction in USH show conflicting results. We aim to evaluate olfactory impairment as a possible clinical manifestation of USH. Prospective clinical study that included 65 patients with USH and 65 normal age-gender-smoking-habits pair matched subjects. A cross culturally validated version of the Sniffin’ Sticks olfaction test was used. Young patients with USH have significantly better olfactory scores than healthy controls. We observe that USH type 1 have a faster ageing olfactory decrease than what happens in healthy subjects, leading to significantly lower olfactory scores in older USH1 patients. Moreover, USH type 1 patients showed significantly higher olfactory scores than USH type 2, what can help distinguishing them. Olfaction represents an attractive tool for USH type classification and pre diagnostic screening due to the low cost and non-invasive nature of the testing. Olfactory dysfunction should be considered among the spectrum of clinical manifestations of Usher syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Accelerated age-related olfactory decline among type 1 Usher patients

Ribeiro

Oliveiros

Pereira

et al. 2016

Sci Rep

Self Cite

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“…Nowadays, a wide range of different antibiotics are available, and their antimicrobial properties provide large fields of application for treatment of infectious diseases . In the past, different case reports and investigations led to the assumption that intake of some antibiotic agents can provoke olfactory dysfunction …”

Section: Drugs Which Exert Negative Impact On Olfactionmentioning

confidence: 99%

“…In a review in 2003, Doty et al reported on the influence of antihypertensive and antihyperlipidemic drugs on the sense of taste and smell followed by another review in 2004 with the emphasis more on flavour (retronasal olfactory stimulation) . Most recently, Lötsch et al analysed interactions between drugs and targets (2015) . Now, we provide another update on this topic analysing other agents with harmful influences on the sense of smell and medicaments that are commonly administered to patients.…”

Section: Introductionmentioning

confidence: 97%

Influence of drugs on smelling capacity. A review

Thiermann¹,

Buchbauer²

2017

Flavour & Fragrance J

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A well‐functioning sense of smell is essential not only for human wellbeing and the quality of life, it is also important to protect the organism from harmful influences it is exposed to, such as gas, toxic agents or rotten food. Various drugs interfere with human olfaction and are able to elicit olfactory dysfunction, but little is known about the underlying mechanisms. To date, a wide range of drugs have not been sufficiently investigated with respect to their impact on olfaction. This review provides an overview of drugs that have been identified as inducing olfactory disorders and discusses underlying causes and mechanisms.

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“…Klinik raporlar, ilaç referans kitapları, ilaç ekleri ve klinik çalışmalar, tat duyusunda bozukluğa neden olan 350'den fazla ilaç ve koku duyusunda değişikliğe neden olan 70'in üzerinde ilaç bulunduğunu göstermiştir. [3][4][5][6][7][8] Koku ve tat duyularındaki değişiklikler tıbbi olarak gerektiği kadar dikkate alınmamaktadır. Bu durum, sadece hastanın tat veya koku alma bozukluğu ile yaşamasına yol açmamakta, yemeklerden hoşnutsuz olmak, keyif alamamak gibi sosyal açılardan da kişinin hayatını olumsuz etkilemektedir.…”

Section: Introductionunclassified

İlaçların Neden Olduğu Tat ve Koku Alma Bozuklukları

Başaran

Bacanlı

2020

Turkish Journal of Family Medicine and Primary Care

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Odor and taste are important in vital functions. With taste-taking, human social life and dietary habits are affected all kinds. Besides, odor and taste have quite complex structures at the molecular level. It is claimed that most of the drugs used in the treatment of different diseases lead to disturbances in taste and smell as an undesirable effect. Changes in smell and taste sensations are not considered as medical necessity. This situation does not only cause the patient to live with taste or smell disorder, but also make person to be disaffected by the food and not to enjoy the social aspects of the person's life. The purpose of this review is to describe the effects of drugs on taste and smell sensations and to provide information about the drugs that can cause these effects.

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Olfactory drug effects approached from human-derived data

Cited by 28 publications

References 77 publications

Accelerated age-related olfactory decline among type 1 Usher patients

Accelerated age-related olfactory decline among type 1 Usher patients

Influence of drugs on smelling capacity. A review

İlaçların Neden Olduğu Tat ve Koku Alma Bozuklukları

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