Olfactory deficits in patients with schizophrenia and severe polydipsia

Divergent effects of two different doses of intranasal oxytocin on facial affect discrimination in schizophrenic patients with and without polydipsia

“…Polydipsic subjects' abilities to correctly identify odors were diminished relative to subjects in each of the other two groups, replicating previous evidence of olfactory dysfunction in those with polydipsia (Kopala et al 1998). Polydipsic subjects were older than healthy controls but did not differ from the other patient group on demographic measures.…”

Differential Olfactory Identification in Children with Autism and Asperger’s Disorder: A Comparative and Longitudinal Study

“…OFC damage results mainly in OI deficits, whereas damage to the lower processing areas results in odour detection deficits (Savage et al 2002). Clinical populations with neurodevelopmental limbic-prefrontal axis compromise show OI deficits, including schizophrenia (Kopala et al 1998), first episode psychosis (Brewer et al 2001), obsessive-compulsive disorder (Barnett et al 1999), posttraumatic stress disorder (Vasterling et al 2000), and attention deficit hyperactivity disorder (Karsz et al 2008).…”

Stability of Olfactory Identification Deficits in Neuroleptic-Naive Patients With First-Episode Psychosis

“…The deficit could not be explained by peripheral factors that might contribute to olfactory identification ability, suggesting that it reflects central mechanisms. St udies in schizophrenia have consistently found deficits in the identification of various smells, usually among male rather than female patients (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), and in the presence of intact ability to detect odor (2,6,15,19). The majority of these studies have examined patients with chronic illness who were taking neuroleptic medication, although the available evidence suggests that these deficits are not explained by medication (6)(7)(8)13) or other confounds such as smoking (1,3,5,9,12).…”