Olfactory bulbectomy depresses ultrasound production and scent marking by female hamsters

Kairys, David J.; Magalhaes, Hulda; Floody, Owen R.

doi:10.1016/0031-9384(80)90195-x

Cited by 24 publications

(9 citation statements)

References 8 publications

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“…Preferential marking toward male odors requires early experience with scents from male siblings (Maras and Petrulis, 2008a) similar to the development of odor preference in female mice (Moncho-Bogani et al, 2002). Not surprisingly, OBX greatly reduces vaginal marking toward males (Kairys et al, 1980). The MOS is the primary chemoreceptive system driving vaginal marking as VNO removal has minimal effect on vaginal marking whereas MOE destruction reduces the behavior (Johnston, 1992; Petrulis et al, 1999).…”

Section: Proceptive or Solicitation Behavior (Beach 1976)mentioning

confidence: 98%

“…The USV response to male scents requires chemosensory input as OBX in females greatly reduced USVs toward males (Kairys et al, 1980) and removal of either VNO or MOE also substantially reduced USVs toward male odors (Johnston, 1992). The neural pathway controlling this response involves the MA (Kirn and Floody, 1985) and its connections to MPOA (Floody, 1989) with an inhibitory system originating in the lateral septum (Floody, 1993; Imondi and Floody, 1998; Kirn and Floody, 1985).…”

Section: Proceptive or Solicitation Behavior (Beach 1976)mentioning

confidence: 99%

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Chemosignals, hormones and mammalian reproduction

Petrulis

2013

Hormones and Behavior

120

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Many mammalian species use chemosignals to coordinate reproduction by altering the physiology and behavior of both sexes. Chemosignals prime reproductive physiology so that individuals become sexually mature and active at times when mating is most probable and suppress it when it is not. Once in reproductive condition, odors produced and deposited by both males and females are used to find and select individuals for mating. The production, dissemination and appropriate responses to these cues are modulated heavily by organizational and activational effects of gonadal sex steroids and thereby intrinsically link chemical communication to the broader reproductive context. Many compounds have been identified as “pheromones” but very few have met the expectations of that term: a unitary, species-typical substance that is both necessary and sufficient for an experience-independent behavioral or physiological response. In contrast, most responses to chemosignals are dependent or heavily modulated by experience, either in adulthood or during development. Mechanistically, chemosignals are perceived by both main and accessory (vomeronasal) olfactory systems with the importance of each system tied strongly to the nature of the stimulus rather than to the response. In the central nervous system, the vast majority of responses to chemosignals are mediated by cortical and medial amygdala connections with hypothalamic and other forebrain structures. Despite the importance of chemosignals in mammals, many details of chemical communication differ even among closely related species and defy clear categorization. Although generating much research and public interest, strong evidence for the existence of a robust chemical communication among humans is lacking.

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Section: Proceptive or Solicitation Behavior (Beach 1976)mentioning

confidence: 98%

Section: Proceptive or Solicitation Behavior (Beach 1976)mentioning

confidence: 99%

Chemosignals, hormones and mammalian reproduction

Petrulis

2013

Hormones and Behavior

120

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“…This suggests that maintaining flank marking requires MOS input, but also that the AOS transmits information about same-sex odors to neural structures that generate flank marking. Indeed, combined damage to both systems, by removing MOB/AOB [47] or LOT transection [57,85], eliminates flank marking completely.…”

Section: Sexual Odor Recognitionmentioning

confidence: 99%

“…As the behavior is regulated by odors it is not surprising that vaginal marking in response to male odors is greatly reduced by OB removal [47]. More selective damage to MOS, via peripheral ZnSO 4 lesions, produces decrements in vaginal marking but less than those following OB removal [38].…”

Section: Sexual Odor Recognitionmentioning

confidence: 99%

Neural mechanisms of individual and sexual recognition in Syrian hamsters (Mesocricetus auratus)

Petrulis

2009

Behavioural Brain Research

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Recognizing the individual and sexual identities of conspecifics is critical for adaptive social behavior and, in most mammals this information is communicated primarily by chemosensory cues. Due to its heavy reliance on odor cues, we have used the Syrian hamster as our model species for investigating the neural regulation of social recognition. Using lesion, electrophysiological and immunocytochemical techniques, separate neural pathways underlying recognition of individual odors and guidance of sex-typical responses to opposite-sex odors have been identified in both male and female hamsters. Specifically, we have found that recognition of individual odor identity requires olfactory bulb connections to entorhinal cortex (ENT) rather than other chemoreceptive brain regions. This kind of social memory does not appear to require the hippocampus and may, instead, depend on ENT connections with piriform cortex. In contrast, sexual recognition, through either differential investigation or scent marking toward opposite-sex odors, depends on both olfactory and vomeronasal system input to the corticomedial amygdala. Preference for investigating opposite-sex odors requires primarily olfactory input to the medial amygdala (ME) whereas appropriately targeted scent marking responses require vomeronasal input to ME as well as to other structures. Within the ME, the anterior section (MEa) appears important for evaluating or classifying social odors whereas the posterodorsal region (MEpd) may be more involved in generating approach to social odors. Evidence is presented that analysis of social odors may initially be done in MEa and then communicated to MEpd, perhaps through micro-circuits that separately process male and female odors.

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“…In most mammalian species, including Syrian hamsters, chemosensory signals from conspecifics are initially detected and processed by two distinct but interconnected systems, the main and accessory olfactory systems (Keller et al, 2009). Disruption of inputs to the main (Johnston, 1992) or accessory (Petrulis et al, 1999) olfactory bulbs, or ablation of the olfactory bulbs themselves (Kairys et al, 1980), decreases vaginal marking to males or their odors. Sexual odor information is transmitted from the olfactory bulbs to areas throughout the ventral forebrain, including the medial amygdala (MA), the posterior division of the bed nucleus of the stria terminalis (BNST), and the medial preoptic area (MPOA) (Coolen and Wood, 1998; Davis et al, 1978; Gomez and Newman, 1992; Wood and Swann, 2005).…”

Section: Introductionmentioning

confidence: 99%

Endogenous oxytocin is necessary for preferential Fos expression to male odors in the bed nucleus of the stria terminalis in female Syrian hamsters

Martínez¹,

Levy²,

Petrulis³

2013

Hormones and Behavior

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Successful reproduction in mammals depends on solicitational behaviors that enhance the probability of encountering potential mates. In female Syrian hamsters, one such behavior is vaginal scent marking. Recent evidence suggests that the neuropeptide oxytocin (OT) may be critical for regulating this behavior. Blockade of OT receptors in the bed nucleus of the stria terminalis (BNST) or the medial preoptic area (MPOA) decreases vaginal marking responses to male odors; lesion data suggest that BNST, rather than MPOA, mediates this effect. However, how OT interacts with sexual odor processing to drive preferential solicitation is not known. To address this issue, intact female Syrian hamsters were exposed to male or female odors and their brains processed for immunohistochemistry for Fos, a marker of recent neuronal activation, and OT. Additional females were injected intracerebroventricularly (ICV) with an oxytocin receptor antagonist (OTA) or vehicle, and then tested for vaginal marking and Fos responses to sexual odors. Colocalization of OT and Fos in the paraventricular nucleus of the hypothalamus was unchanged following exposure to male odors, but decreased following exposure to female odors. Following injections of OTA, Fos expression to male odors was decreased in BNST, but not in MPOA or the medial amygdala (MA). Fos expression in BNST may be functionally relevant for vaginal marking, given that there was a positive correlation between Fos expression and vaginal marking for BNST, but not MPOA or MA. Together, these data suggest that OT facilitation of neuronal activity in BNST underlies the facilitative effects of OT on solicitational responses to male odors.

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Olfactory bulbectomy depresses ultrasound production and scent marking by female hamsters

Cited by 24 publications

References 8 publications

Chemosignals, hormones and mammalian reproduction

Chemosignals, hormones and mammalian reproduction

Neural mechanisms of individual and sexual recognition in Syrian hamsters (Mesocricetus auratus)

Endogenous oxytocin is necessary for preferential Fos expression to male odors in the bed nucleus of the stria terminalis in female Syrian hamsters

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