Olfactory and trigeminal event-related potentials in migraine

Grosser, K; Oelkers, R; Hummel, Thomas; Geißlinger, Gerd; Brune, Kay; Kobal, Gerd; Lötsch, Jörn

doi:10.1046/j.1468-2982.2000.00094.x

Cited by 26 publications

(32 citation statements)

References 52 publications

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“…Disruption of habituation has been described in diseased state, like tinnitus [80] where deafferentation of acoustic cortex is believed to be the principal pathogenetic mechanism. On the other hand, receptorial dysfunction in visual [81], olfactory [82] and more recently in auditory [83] and vestibular systems [84, 85] have been described in migraine. Could they play any role in generation of functional cortical abnormalities observed in this disease, through mechanisms like those operating in deafferentation?…”

Section: Conclusion and Final Remarksmentioning

confidence: 99%

Cortical inhibition and habituation to evoked potentials: relevance for pathophysiology of migraine

2009

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Dysfunction of neuronal cortical excitability has been supposed to play an important role in etiopathogenesis of migraine. Neurophysiological techniques like evoked potentials (EP) and in the last years non-invasive brain stimulation techniques like transcranial magnetic stimulation (TMS) and transcranial direct current stimulation gave important contribution to understanding of such issue highlighting possible mechanisms of cortical dysfunctions in migraine. EP studies showed impaired habituation to repeated sensorial stimulation and this abnormality was confirmed across all sensorial modalities, making defective habituation a neurophysiological hallmark of the disease. TMS was employed to test more directly cortical excitability in visual cortex and then also in motor cortex. Contradictory results have been reported pointing towards hyperexcitability or on the contrary to reduced preactivation of sensory cortex in migraine. Other experimental evidence speaks in favour of impairment of inhibitory circuits and analogies have been proposed between migraine and conditions of sensory deafferentation in which down-regulation of GABA circuits is considered the more relevant pathophysiological mechanism. Whatever the mechanism involved, it has been found that repeated sessions of high-frequency rTMS trains that have been shown to up-regulate inhibitory circuits could persistently normalize habituation in migraine. This could give interesting insight into pathophysiology establishing a link between cortical inhibition and habituation and opening also new treatment strategies in migraine.

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Section: Conclusion and Final Remarksmentioning

confidence: 99%

Cortical inhibition and habituation to evoked potentials: relevance for pathophysiology of migraine

2009

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“…The predominant theory is that the activation of this nerve results in release of neuropeptides such as substance P, calcitonin gene‐related peptide, and neurokinin A 7,8 . These peptides cause neurogenic inflammation 9–14 . What activates the terminal branches of the trigeminal nerve, however, remains unknown.…”

Section: Commentsmentioning

confidence: 99%

Single‐Site Botulinum Toxin Type A Injection for Elimination of Migraine Trigger Points

Behmand¹,

Tucker²,

Guyuron³

2003

Headache

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“…Enhanced EP amplitudes (Grosser et al, 2000), diminished (Weiss et al, 2003) or unaltered amplitudes (De Tommaso et al, 2005) have been reported for migraineurs compared to healthy controls. In adult migraineurs, studies that examined nociceptive evoked potentials (EPs) interictally have yielded mixed results.…”

Section: Introductionmentioning

confidence: 99%

Altered pain processing in children with migraine: An evoked potential study

Zohsel

Hohmeister

Flor

et al. 2008

European Journal of Pain

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In adults, evidence is accumulating that migraine is associated with altered central processing of pain stimuli and, possibly, changes in the allocation of attentional resources to such stimuli. In pediatric migraine, however, little is known about altered pain processing. We examined 15 children with migraine and 15 controls (age 10-15) in an oddball standards task. Children had to respond to rare targets (tones) and ignore frequent painful (pain threshold) or non-painful mechanical standard stimuli while evoked potentials were obtained. Painful as compared to non-painful stimuli elicited significantly larger N150, P260 and P300 components of the somatosensory evoked potential in all children. The pain-evoked N150 and P260 components did not differ significantly between groups. However, in children with migraine, both painful and non-painful standard stimuli were associated with significantly larger P300 amplitudes at significantly shorter latencies. Perceived intensity of the painful and non-painful stimuli was comparable in both groups. The evoked potentials and reaction times to the target tones did not differ significantly between groups. Habituation across trials was similar in both groups. Hence, children with migraine may display an automatic attentional bias towards painful and potentially painful somatosensory stimuli. Consistent with the psychobiological perspective of chronic pain, such an attentional bias could constitute an important mechanism for migraine becoming a chronic problem.

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Olfactory and trigeminal event-related potentials in migraine

Cited by 26 publications

References 52 publications

Cortical inhibition and habituation to evoked potentials: relevance for pathophysiology of migraine

Cortical inhibition and habituation to evoked potentials: relevance for pathophysiology of migraine

Single‐Site Botulinum Toxin Type A Injection for Elimination of Migraine Trigger Points

Altered pain processing in children with migraine: An evoked potential study

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