Olfactory and taste dysfunction in coronavirus disease 2019 patients: its prevalence and outcomes

Jain, Avani; Kumar, Lakshman; Kaur, Jasleen; Baisla, T; Goyal, Praveen; Pandey, Ashok; Das, Asim Bikas; Parashar, Lokesh

doi:10.1017/s0022215120002467

Cited by 19 publications

(22 citation statements)

References 23 publications

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“…In adults, anosmia and dysgeusia in COVID-19 patients has been widely reported in literature with a varying prevalence. There is a difference in the prevalence of olfactory and taste dysfunction between the Asian 14 , 15 , 16 and European population 17 , 18 , 19 , 20 , 21 , 22 . This may be due to increased expression of ACE2 in the European population as compared to the Asian population 23 .…”

Section: Discussionmentioning

confidence: 99%

“…This rapid and spontaneous recovery of OTD has also been reported in adult COVID-19 patients. Some studies report that chemosensory loss in COVID-19 adult patients recovers in about 1-2 weeks of onset, in conjunction with improvement of infection 14 , 17 . This short duration and spontaneous recovery supports the findings that SARS-CoV-2 targets the non neural olfactory epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

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Loss of smell and taste in COVID-19 infection in adolescents

Kumar

Kahlon

Jain

et al. 2021

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Loss of smell and taste in COVID-19 infection in adolescents

Kumar

Kahlon

Jain

et al. 2021

International Journal of Pediatric Otorhinolaryngology

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“…An expert who carried out animal experiments has confirmed that coronavirus is highly neurotropic and can directly affect olfactory neurons, which might be another fundamental cause of olfactory dysfunctions induced by the novel coronavirus [ 70 ]. When the potential target of SARS-CoV-2 is located in non-neuro-olfactory epithelial cells, the patient's olfactory function often recovers within 2 to 4 weeks [ 71 ]. Significantly, once the virus infects olfactory stem cells, such as horizontal basal cells, it can cause long-term olfactory dysfunctions [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and prognosis of otorhinolaryngological symptoms in patients with COVID-19: a systematic review and meta-analysis

Qiu

Yang

Liu

et al. 2021

Eur Arch Otorhinolaryngol

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Objective A systematic review and meta-analysis were performed to evaluate the prevalence and prognosis of otorhinolaryngological symptoms in patients with the diagnosed coronavirus disease 2019 . Methods A systematic search of PubMed, Embase, Web of Science, and Google Scholar databases was performed up to August 19, 2020.We included studies that reported infections with COVID-19 and symptoms of otolaryngology. The retrieved data from the respective studies were evaluated and summarized. The study's immediate result was to assess the combined prevalence of otorhinolaryngological symptoms in patients with COVID-19. However, the secondary result was to determine the exacerbation of COVID-19 infection in patients with otorhinolaryngological symptoms. Results Fifty-four studies with 16,478 patients were included. Olfactory dysfunction, sneezing and sputum production were the 3 most prevalent otorhinolaryngological symptoms in patients with COVID-19. The pooled prevalence amongst the prevalent symptoms was 47% (95% CI 29-65; range 0-98; I 2 = 99.58%), 27% (95% CI 11-48; range 12-40; I 2 = 93.34%), and 22% (95% CI 16-30; range 2-56; I 2 = 97.60%), respectively. The proportion of severely ill patients with sputum production and shortness of breath was significantly higher among patients with COVID-19 infections (OR 1.66 [95% CI 1.08-2.54]; P = 0.02, I 2 = 51% and 3.29 [95% CI 1.57-6.90]; P = 0.002, I 2 = 49%, respectively). Subgroup analysis showed no statistically significant differences between the incidence of otolaryngology symptoms in severely ill patients and non-severely ill patients (OR 1.43 [95% CI 1.12-1.82]; P = 0.07 I 2 = 53.1%). In contrast, the incidence of shortness of breath in severely ill patients was significantly increased (3.29 [1.57-6.90]; P = 0.002, I 2 = 49%). Conclusion Our research shows that otorhinolaryngology symptoms in patients with COVID-19 are not uncommon, which should attract otorhinolaryngologists' attention.

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“…7 This supplements and complements recent articles in The Journal on acute care, by Osborne and colleagues, 8 on ethics, by Leonard, 9 and on smell and taste dysfunction, by Jain and colleagues. 10…”

mentioning

confidence: 99%

Acute ENT care, cochlear implantation and otitis media in the pandemic, and ENT post-graduate education

Fisher¹,

Fishman²

2021

J. Laryngol. Otol.

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We reach this month, the first anniversary of the West hearing the word 'lockdown', in relation to a large city in China. Wuhan is an important academic and commercial hub, but was perhaps not a place known to the majority of the world's population until a year ago. We at The Journal of Laryngology & Otology continue to receive a flow of articles in relation to coronavirus disease 2019 (Covid-19) from around the world, and endeavour to publish those that we feel add something new, interesting or useful. Colleagues grapple globally with the basic sciences relevant to ENT, the practicalities and the implications for ENT services during this 'war' with a virus and its aftermath. Despite the increase in article submissions, being a journal editor at the moment is surely more comfortable than being a local or national politician. The Oxford English Dictionary notes a dramatic increase during 2020 of words such as 'circuit breaker', 'lockdown', 'shelter-in-place', 'bubbles', 'face masks' and 'key workers'. The over-use of 'unprecedented' is often mentioned, but the Oxford English Dictionary comments: '…what was genuinely unprecedented this year was the hyper-speed at which the English-speaking world amassed a new collective vocabulary relating to the coronavirus, and how quickly it became, in many instances, a core part of the language'. 1 We approach the anniversary of the coining of 'Covid-19', which first appeared in February 2020. This issue covers the matters of otitis media in the Covid-19 era, from Iran; 2 the feasibility of paediatric cochlear implantation, from the North of England; 3 rapid access (urgent) ENT care, 4 protection during microlaryngoscopy, 5 dysgeusia symptoms 6 and transnasal humidified rapid-insufflation ventilatory exchange ('THRIVE') during the pandemic. 7 This supplements and complements recent articles in The Journal on acute care, by Osborne and colleagues, 8 on ethics, by Leonard, 9 and on smell and taste dysfunction, by Jain and colleagues. 10 The imposed unwelcome revolution in working practices has been superimposed on an evolution of education and training in ENT, not only in the UK, but around the world. Surgical colleges, regulatory bodies (such as the General Medical Council), specialty associations, hospitals, deaneries and universities have all been grappling with this. How to reconcile a need for ENT skills in the general medical workforce (general practitioners and others) and specialists with the barriers imposed by a crowded undergraduate and postgraduate curriculum? Undergraduate and postgraduate curricula are increasingly time-pressured, and a political imperative to increase throughput must be balanced against a professional desire to maintain or improve quality. One such scheme in the UK has been 'run-through' training, in which young doctors make a firm commitment to the specialty (shortly after qualifying in medicine) and are carried right through to independent specialist practice. This issue of The Journal includes a representative survey of a cohort of recent traine...

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Olfactory and taste dysfunction in coronavirus disease 2019 patients: its prevalence and outcomes

Cited by 19 publications

References 23 publications

Loss of smell and taste in COVID-19 infection in adolescents

Loss of smell and taste in COVID-19 infection in adolescents

Prevalence and prognosis of otorhinolaryngological symptoms in patients with COVID-19: a systematic review and meta-analysis

Acute ENT care, cochlear implantation and otitis media in the pandemic, and ENT post-graduate education

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