Olfactory and Gustatory Dysfunction in Pediatric Patients With Coronavirus Disease (COVID-19)

Abraira, M Bernaola; Peñas, I Bartha De Las; López-Araujo, G A; Diez, C Escudero; Río, Pablo Rodríguez del; Morales‐Cabeza, Cristina; Batiz, R Bazire; Sandín, María

doi:10.18176/jiaci.0677

Cited by 4 publications

(13 citation statements)

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“…used the Alinamin® test, an intravenous olfaction test. 6 Questionnaire evaluation was used in three studies, 4 , 11 , 12 and a visual analogue scale was used in two studies. 6 , 11 …”

Section: Resultsmentioning

confidence: 99%

“…A total of nine articles, originally published online between 1 December 2019 and 30 April 2021, that fulfilled the selection criteria were included in the review (Table 1). [4][5][6][7][8][9][10][11][12] The articles included three retrospective studies, 4,5,11 three case reports, 6,9,10 two prospective studies 7,12 and one case series. 8 Patients were from Asia in five articles, [6][7][8]10,11 Europe in four articles 4,5,9,11 and Russia in one article.…”

Section: Resultsmentioning

confidence: 99%

“…[4][5][6][7][8][9][10][11][12] The articles included three retrospective studies, 4,5,11 three case reports, 6,9,10 two prospective studies 7,12 and one case series. 8 Patients were from Asia in five articles, [6][7][8]10,11 Europe in four articles 4,5,9,11 and Russia in one article. 12 One study included patients from three countries: China, Germany and France.…”

Section: Resultsmentioning

confidence: 99%

“…Only five studies reported on the mode of olfactory assessment: objective evaluation was carried out in four studies 5,6,11,12 and subjective assessment in four studies. 4,6,11,12 The psychophysical assessment was performed using an odour identification test in four articles. 5,6,11,12 Kasuga et al used the Alinamin ® test, an intravenous olfaction test.…”

Section: Resultsmentioning

confidence: 99%

“…5,6,11,12 Kasuga et al used the Alinamin ® test, an intravenous olfaction test. 6 Questionnaire evaluation was used in three studies, 4,11,12 and a visual analogue scale was used in two studies. 6,11 None of the included studies mentioned distortion or alteration of smell such as parosmia or phantosmia.…”

Section: Resultsmentioning

confidence: 99%

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Olfactory dysfunction amongst children and adolescents with laboratory confirmed coronavirus disease 2019: a systematic review

2021

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Background Despite the rapidly emerging reports of olfactory dysfunction amongst adult patients with coronavirus disease 2019, cases involving children and adolescents are scarcely reported. The literature was reviewed to elucidate olfactory dysfunction amongst children and adolescents with coronavirus disease 2019. Methods A search of the literature published from 1 December 2019 to 30 April 2021 was conducted using four databases, based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. The search was performed over one month (May 2021). Results Only 9 articles were identified, with a total of 316 laboratory confirmed coronavirus disease 2019 positive children and adolescents, of whom 156 reported olfactory dysfunction. Four studies reported olfactory dysfunction based on subjective tests; four studies carried out objective assessment. Most studies reported on olfaction recovery. Conclusion The literature review revealed an olfactory dysfunction rate of 49 per cent amongst children and adolescents with coronavirus disease 2019. Persistence of olfactory dysfunction was reported in 7.1 per cent of the patients. Further studies involving objective measures need to be carried out in children and adolescents with coronavirus disease 2019.

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“…used the Alinamin® test, an intravenous olfaction test. 6 Questionnaire evaluation was used in three studies, 4 , 11 , 12 and a visual analogue scale was used in two studies. 6 , 11 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Olfactory dysfunction amongst children and adolescents with laboratory confirmed coronavirus disease 2019: a systematic review

2021

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A systematic review and meta-analysis of otorhinolaryngological manifestations of coronavirus disease 2019 in paediatric patients

Yadav

Singh²,

Meena

et al. 2022

J. Laryngol. Otol.

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Background This meta-analysis provides a quantitative measure of the otorhinolaryngological manifestations of coronavirus disease 2019 in children. Methods A structured literature review was carried out using PubMed, Embase and Cochrane Central, employing pertinent search terms. The statistical analysis was performed using Stata version 14.2 software, and the analysed data were expressed as the pooled prevalence of the symptoms with 95 per cent confidence intervals. Results The commonest symptoms noted were cough (38 per cent (95 per cent confidence interval = 33–42; I2 = 97.5 per cent)), sore throat (12 per cent (95 per cent confidence interval =10–14; I2 = 93.7 per cent)), and nasal discharge (15 per cent (95 per cent confidence interval = 12–19; I2 = 96.9 per cent)). Anosmia and taste disturbances showed a pooled prevalence of 8 per cent each. Hearing loss, vertigo and hoarseness were rarely reported. Conclusion Cough, sore throat and nasal discharge were the commonest otorhinolaryngological symptoms in paediatric patients with coronavirus disease 2019. Compared with adults, anosmia and taste disturbances were infrequently reported in children.

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Subjective Smell Disturbances in Children with Sars-Cov-2 or Other Viral Infections do not Correspond with Olfactory Test Results

Grote,

Hoffmann,

Kerzel

et al. 2024

Klin Padiatr

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Background Olfactory dysfunction associated with SARS-CoV-2 infection in children has not been verified by a validated olfactory test. We aimed to determine whether these complaints are objectifiable (test-based hyposmia), how often they occur during acute SARS-CoV-2 infection compared to other upper respiratory tract infections (URTI), as well as in children recovered from COVID-19 compared to children with long COVID. Methods Olfactory testing (U-sniff test; hyposmia<8 points) and survey-based symptom assessments were performed in 434 children (5–17 years; 04/2021–06/2022). 186 symptom-free children served as controls. Of the children with symptoms of acute respiratory tract infection, SARS-CoV-2 PCR test results were positive in 45 and negative in 107 children (URTI group). Additionally, 96 children were recruited at least 4 weeks (17.6±15.2 weeks) after COVID-19, of whom 66 had recovered and 30 had developed long COVID. Results Compared to controls (2.7%), hyposmia frequency was increased in all other groups (11–17%, p<0.05), but no between-group differences were observed. Only 3/41 children with hyposmia reported complaints, whereas 13/16 children with complaints were normosmic, with the largest proportion being in the long-COVID group (23%, p<0.05). Conclusion Questionnaires are unsuitable for assessing hyposmia frequency in children. Olfactory complaints and hyposmia are not specific for SARS-CoV-2 infection. The number of complaints in the long-COVID group could result from aversive olfactory perception, which is undetectable with the U-sniff test.

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Olfactory and Gustatory Dysfunction in Pediatric Patients With Coronavirus Disease (COVID-19)

Cited by 4 publications

References 0 publications

Olfactory dysfunction amongst children and adolescents with laboratory confirmed coronavirus disease 2019: a systematic review

Olfactory dysfunction amongst children and adolescents with laboratory confirmed coronavirus disease 2019: a systematic review

A systematic review and meta-analysis of otorhinolaryngological manifestations of coronavirus disease 2019 in paediatric patients

Subjective Smell Disturbances in Children with Sars-Cov-2 or Other Viral Infections do not Correspond with Olfactory Test Results

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