Olfactory and gustatory dysfunction in COVID‐19 patients: A meta‐analysis study

Hajikhani, Bahareh; Calcagno, Tess Moore; Nasiri, Mohammad Javad; Jamshidi, Parnian; Dadashi, Masoud; Goudarzi, Mehdi; Eshraghi, Adrien A.; Mirsaeidi, Mehdi

doi:10.14814/phy2.14578

Cited by 49 publications

(43 citation statements)

References 34 publications

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“…For example, Hajikhani et al analyzed 3739 patients from 15 studies with PCR-confirmed COVID-19. 17 The taste and smell impairment rates were 49% and 61%, respectively. Among patients hospitalized in the ICU, we found that 42.3% (n ¼ 22/52) experienced taste and/or smell impairment, consistent with the findings of previous studies.…”

Section: Discussionmentioning

confidence: 97%

Taste and Smell Impairment in Critically Ill Patients With COVID-19: An Intensive Care Unit Study

et al. 2020

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Objective: To determine taste and smell impairment rates in patients with coronavirus disease 2019 (COVID-19) who were hospitalized in the intensive care unit (ICU). Methods: Between March 2020 and May 2020, patients with COVID-19 hospitalized in the ICU were enrolled in this study. Upon discharge, patients were telephoned and asked to complete a survey related to taste and smell impairment. Characteristics were compared between patients with and without taste and/or smell impairment. Results: Fifty-two patients were enrolled (mean age, 61.32 ± 12.53 years; mean ICU stay, 10.19 ± 10.24 days). Age, sex, type/number of comorbid diseases, most ICU support modalities, and ICU stay duration did not significantly differ between groups. Patients in group B required more high-flow nasal oxygen therapy than patients in group A ( P = .010). In total, 22 (42.3%) of 52 patients experienced taste and/or smell impairment. Three patients experienced isolated smell impairment and one patient experienced isolated taste impairment. Among the 21 patients who experienced smell impairment, 18 (85.78%) experienced hyposmia (mean visual analog scale [VAS] score: 6.33 ± 0.97), while 3 (14.28%) experienced anosmia. Among the 19 patients who experienced taste impairment, 16 (84.22%) experienced hypogeusia (mean VAS score: 6.43 ± 1.03) and 3 (15.78%) experienced ageuisa. Among 22 patients who experienced taste and/or smell impairment, 15 (68.18%) patients (n = 15/22) experienced smell and/or taste impairment before the ICU stay, while 7 (31.82%) patients (n = 7/22) experienced impairment during the ICU stay. Overall, 28.84% (n = 15/52) of the patients experienced taste and/or smell impairment before the ICU stay. Conclusions: Patients who were hospitalized in the ICU experienced lower rates of taste and/or smell impairment. Some patients experienced taste and/or smell impairment during the ICU stay.

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Section: Discussionmentioning

confidence: 97%

Taste and Smell Impairment in Critically Ill Patients With COVID-19: An Intensive Care Unit Study

et al. 2020

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“…On the other hand, the proportion of patients experiencing chemosensory dysfunction was relatively high. According to a metanalysis by Hajikhani et al, 34 at presentation, the estimated rate of taste disorders was 49.0% and of olfactory disorders was 61.0%. Data regarding the short-term recovery from these symptoms are divergent.…”

Section: Discussionmentioning

confidence: 99%

Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge

et al. 2021

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Key Points Question What respiratory, functional, and psychological sequalae are associated with recovery from coronavirus disease 2019 (COVID-19)? Findings In this cohort study of 238 patients with COVID-19 hospitalized in an academic hospital in Northern Italy, more than half of participants had a significant reduction of diffusing lung capacity for carbon monoxide or measurable functional impairment and approximately one-fifth of patients had symptoms of posttraumatic stress 4 months after discharge. Meaning These findings suggest that despite virological recovery, a sizable proportion of patients with COVID-19 experienced respiratory, functional, or psychological sequelae months after hospital discharge.

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“…Nonetheless, evidence has accumulated showing that two atypical symptoms, the loss of taste and/or loss of smell, may be frequently triggered by SARS-CoV-2 infection [7]. This is supported by some recent meta-analyses, such as those published by Hajikhani et al [8], as well as by Tong and colleagues [9], who reported that olfactory and gustatory dysfunctions are present in over 50% of patients with SARS-CoV-2 infection. Notably, the recent meta-analysis of Hoang et al also revealed that olfactory and/or gustatory dysfunctions might also be highly specific symptoms of SARS-CoV-2 infection, since they were found to be 10-fold more likely to occur in COVID-19 patients as opposed to those with other acute respiratory infections (odds ratio, 11.3; 95% confidence interval [95% CI], 5.4-23.4) [10].…”

Section: Introductionmentioning

confidence: 85%

Google Searches for Taste and Smell Loss Anticipate Covid-19 Epidemiology

Lippi

Henry

Mattiuzzi³

et al. 2020

Preprint

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BackgroundAs evidence emerged that loss of taste and/or loss of smell is frequently triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we investigated whether Google searches volume for these two disease-specific symptoms could be associated with disease epidemiology in United States (US).Materials and MethodsWe performed an electronic search in Google Trends using the keywords “taste loss” and “smell loss” within the US. The Google searches volume was correlated with the number of new weekly cases of coronavirus disease 2019 (COVID-19) in the country.ResultsThe weekly Google searches for taste and smell loss exhibited a trend similar to that of new weekly SARS-CoV-2 infections in the US. A nearly perfect correlation was found between Google Trends scores of taste and smell loss (r=0.98; 95% CI, 0.97-0.99; p<0.001). Although a significant association was found between Google searches for the two symptoms and the concomitant number of new weekly SARS-CoV-2 infections reported during the same week, the correlation improved over time. The highest correlation was found comparing Google Trends scores for taste or smell loss and the number of new weekly SARS-CoV-2 infections two weeks later. The correlation coefficient of summing Google Trends scores for the two symptoms and the number of new weekly SARS-CoV-2 infections two weeks later was 0.82 (95% CI, 0.68-0.90; p<0.001), and was associated 0.89 diagnostic accuracy.ConclusionsThese findings suggest that Google searches numbers for olfactory and gustatory dysfunctions may help predicting the epidemiological trajectory of COVID-19 early before official reporting.

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Olfactory and gustatory dysfunction in COVID‐19 patients: A meta‐analysis study

Cited by 49 publications

References 34 publications

Taste and Smell Impairment in Critically Ill Patients With COVID-19: An Intensive Care Unit Study

Taste and Smell Impairment in Critically Ill Patients With COVID-19: An Intensive Care Unit Study

Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge

Google Searches for Taste and Smell Loss Anticipate Covid-19 Epidemiology

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